HitPredict

Interactor 1: O46034 (O46034)
E3 ubiquitin-protein ligase CBL (EC 2.3.2.27)
Gene: Cbl

Interactor 2: GRAP (Q08012)
Growth factor receptor-bound protein 2 (Downstream of receptor kinase) (Protein enhancer of sevenless 2B)
Gene: drk

Species: Drosophila melanogaster

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.643

Property	Details
Experiments	21340027, 10918586
Identification Methods	affinity chromatography technology, pull down, two hybrid
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001784 - phosphotyrosine residue binding GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0007476 - imaginal disc-derived wing morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 448 Dm			1 211
+	Mm
		1112053 CBLB_MOUSE (33-431): 0: 730: 72.07		GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08
+	Ce
		666213 Q19019_CAEEL (2-435): 0: 732: 52.63		SEM5_CAEEL (1-211): 1.77e-63: 198: 61.03
+	Mm
		82735 B9EKI5_MOUSE (33-431): 0: 729: 72.07		GRB2_MOUSE (1-210): 7.86e-65: 201: 63.08
+	Mm
		1112072 CBLB_MOUSE (33-431): 0: 730: 72.07		GRAP_MOUSE (1-210): 2.36e-57: 182: 52.78
+	Mm
		782847 CBLB_MOUSE (33-431): 0: 730: 72.07		CSK_MOUSE (2-136): 7.37e-26: 105: 36.99
+	Hs
		337458 CBLB_HUMAN (33-431): 0: 729: 72.07		ABL1_HUMAN (4-138): 2.7e-23: 99: 36.43
+	Hs
		69208 CBLB_HUMAN (33-431): 0: 729: 72.07		A9UF07_HUMAN (4-138): 7.5e-23: 97.8: 36.43
+	Mm
		82738 B9EKI5_MOUSE (33-431): 0: 729: 72.07		NCK1_MOUSE (5-143): 1.82e-20: 89.7: 32.35
+	Hs
		557678 CBLB_HUMAN (33-431): 0: 729: 72.07		NCK1_HUMAN (5-143): 2.4e-20: 89.4: 32.35
+	Hs
		802585 CBLB_HUMAN (33-431): 0: 729: 72.07		CRK_HUMAN (48-209): 9e-20: 87: 29.69
+	Mm
		1112058 CBLB_MOUSE (33-431): 0: 730: 72.07		CRK_MOUSE (48-209): 2.18e-19: 85.9: 29.17
+	Hs
		548699 CBLB_HUMAN (33-431): 0: 729: 72.07		VAV_HUMAN (2-60): 7.85e-14: 71.6: 37.29
+	Ce
		220219 Q19019_CAEEL (2-435): 0: 732: 52.63		SRC2_CAEEL (108-211): 9.18e-12: 65.4: 16.07
+	Hs
		412170 CBLB_HUMAN (33-431): 0: 729: 72.07		FYN_HUMAN (160-211): 2.56e-12: 66.9: 27.78
+	Mm
		1112081 CBLB_MOUSE (33-431): 0: 730: 72.07		ITSN2_MOUSE (43-210): 9.78e-12: 65.4: 20.83
+	Mm
		292684 CBLB_MOUSE (33-431): 0: 730: 72.07		GRAP2_MOUSE (3-58): 2.33e-11: 63.8: 33.93
+	Hs
		275194 CBLB_HUMAN (33-431): 0: 729: 72.07		GRAP2_HUMAN (3-56): 7.35e-11: 62.2: 35.19
+	Hs
		433339 CBLB_HUMAN (33-431): 0: 729: 72.07		YES_HUMAN (160-211): 1.47e-10: 61.9: 25.93
+	Hs
		522956 CBLB_HUMAN (33-431): 0: 729: 72.07		SRC_HUMAN (160-211): 1.73e-10: 61.5: 25.93
+	Mm
		82734 B9EKI5_MOUSE (33-431): 0: 729: 72.07		LYN_MOUSE (105-211): 3.63e-10: 60.7: 17.43