Protein: BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (Brefeldin A-inhibited GEP 2) (ADP-ribosylation factor guanine nucleotide-exchange factor 2)

Gene: BIG2, ARFGEF2
Organism: Homo sapiens
Interactions: 137
UniProt ID: Q9Y6D5

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001881 - receptor recycling
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005802 - trans-Golgi network
GO:0005813 - centrosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1491832

BIG1
Brefeldin A-inhibited guanine nucleotide-exchange protein 1

5

9

Small-scale

0.924

High

1411441

CAB45
45 kDa calcium-binding protein

2

3

High-throughput

0.789

High

1351836

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

3

1

High-throughput

0.667

High

1462796

LAMP3
Lysosome-associated membrane glycoprotein 3

3

7

High-throughput

0.667

High

1404078

MYCBP
c-Myc-binding protein

4

1

Small-scale

0.642

High

531187

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

5

Small-scale

0.636

High

1330765

SIGL1
SIGLEC family-like protein 1

2

3

High-throughput

0.628

High

827290

ARL1
ADP-ribosylation factor-like protein 1

1

20

High-throughput

0.618

High

1009915

NUCB2
Nucleobindin-2

1

1

Small-scale

0.618

High

1446730

TMM9B
Transmembrane protein 9B

3

6

High-throughput

0.604

High

1293572

F131B
Protein FAM131B

2

0

High-throughput

0.602

High

1490561

VSIG4
V-set and immunoglobulin domain-containing protein 4

2

7

High-throughput

0.601

High

219032

TGON2
Trans-Golgi network integral membrane protein 2

2

3

High-throughput

0.584

High

631049

RAB4A
Ras-related protein Rab-4A

2

17

High-throughput

0.584

High

1114786

CUL3
Cullin-3

2

5

High-throughput

0.584

High

438113

GLPB
Glycophorin-B

2

1

High-throughput

0.574

High

665331

EDNRB
Endothelin receptor type B

2

9

High-throughput

0.574

High

1101326

SLAF1
Signaling lymphocytic activation molecule

2

10

High-throughput

0.558

High

1420334

CD244
Natural killer cell receptor 2B4

2

8

High-throughput

0.558

High

1434368

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

1382809

PLPL2
Patatin-like phospholipase domain-containing protein 2

1

2

Small-scale

0.552

High

380211

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

6

High-throughput

0.552

High

139368

UPK2
Uroplakin-2

2

4

High-throughput

0.549

High

182861

GP182
G-protein coupled receptor 182

1

18

High-throughput

0.536

High

209153

CYB5B
Cytochrome b5 type B

1

2

High-throughput

0.536

High

220645

AKA10
A-kinase anchor protein 10, mitochondrial

1

2

High-throughput

0.536

High

291886

STK16
Serine/threonine-protein kinase 16

1

3

High-throughput

0.536

High

427967

ICAM1
Intercellular adhesion molecule 1

1

1

High-throughput

0.536

High

476418

K1C16
Keratin, type I cytoskeletal 16

1

4

High-throughput

0.536

High

521058

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

6

High-throughput

0.536

High

634821

GRAH
Granzyme H

1

4

High-throughput

0.536

High

638563

FPR1
fMet-Leu-Phe receptor

1

10

High-throughput

0.536

High

774739

BASI
Basigin

1

9

High-throughput

0.536

High

922854

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

2

High-throughput

0.536

High

1159254

SGCA
Alpha-sarcoglycan

1

1

High-throughput

0.536

High

1294698

K2C73
Keratin, type II cytoskeletal 73

1

1

High-throughput

0.536

High

1324892

LRC25
Leucine-rich repeat-containing protein 25

1

2

High-throughput

0.536

High

1325967

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

3

High-throughput

0.536

High

1363173

CLC2B
C-type lectin domain family 2 member B

1

7

High-throughput

0.536

High

1387014

ORAI1
Calcium release-activated calcium channel protein 1

1

1

High-throughput

0.536

High

1420491

DPY30
Protein dpy-30 homolog

1

1

High-throughput

0.536

High

1430712

F234A
Protein FAM234A

1

2

High-throughput

0.536

High

1451773

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.536

High

1454033

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

6

High-throughput

0.536

High

1460042

CLC2D
C-type lectin domain family 2 member D

1

5

High-throughput

0.536

High

1460800

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

1462355

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

2

High-throughput

0.536

High

1491516

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

4

High-throughput

0.536

High

568871

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

3

Small-scale

0.527

High

622723

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

8

Small-scale

0.515

High

211095

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.513

High

933765

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.513

High

975535

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.513

High

1098187

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.513

High

1106468

MADCA
Mucosal addressin cell adhesion molecule 1

1

0

High-throughput

0.513

High

1383525

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

1

0

High-throughput

0.513

High

1460839

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

280884

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.508

High

1126262

PDE3A
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A

1

3

Small-scale

0.500

High

683381

TNR5
Tumor necrosis factor receptor superfamily member 5

1

8

High-throughput

0.489

High

1037927

HEN2
Helix-loop-helix protein 2

1

3

High-throughput

0.489

High

1090120

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

7

High-throughput

0.489

High

1101718

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

17

High-throughput

0.489

High

1158332

RM23
Large ribosomal subunit protein uL23m

1

1

High-throughput

0.489

High

1232157

VASN
Vasorin

1

2

High-throughput

0.489

High

1350930

HUMMR
Protein MGARP

1

3

High-throughput

0.489

High

1396953

ANM6
Protein arginine N-methyltransferase 6

1

6

High-throughput

0.489

High

1399657

OPALI
Opalin

1

2

High-throughput

0.489

High

1414224

TBB6
Tubulin beta-6 chain

1

1

High-throughput

0.489

High

1462647

KCNH4
Voltage-gated delayed rectifier potassium channel KCNH4

1

3

High-throughput

0.489

High

1491800

NPTN
Neuroplastin

1

11

High-throughput

0.489

High

1462570

EXOC7
Exocyst complex component 7

1

0

Small-scale

0.484

High

140045

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

3

High-throughput

0.479

High

189959

STX7
Syntaxin-7

1

3

High-throughput

0.479

High

226285

STX6
Syntaxin-6

1

7

High-throughput

0.479

High

327521

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.479

High

374313

RASN
GTPase NRas

1

20

High-throughput

0.479

High

375054

RASH
GTPase HRas

1

12

High-throughput

0.479

High

562522

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

568102

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

6

High-throughput

0.479

High

581404

RAC2
Ras-related C3 botulinum toxin substrate 2

1

11

High-throughput

0.479

High

679420

DNJB2
DnaJ homolog subfamily B member 2

1

3

High-throughput

0.479

High

725572

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

3

Small-scale

0.479

High

765158

CTNB1
Catenin beta-1

1

3

Small-scale

0.479

High

786961

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

2

Small-scale

0.479

High

901721

RAB7A
Ras-related protein Rab-7a

1

19

High-throughput

0.479

High

902171

RAB9A
Ras-related protein Rab-9A

1

20

High-throughput

0.479

High

935370

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

976703

RB11A
Ras-related protein Rab-11A

1

7

High-throughput

0.479

High

1145203

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.479

High

1233620

LTOR1
Ragulator complex protein LAMTOR1

1

4

High-throughput

0.479

High

1247070

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

1362023

RFFL
E3 ubiquitin-protein ligase rififylin

1

1

Small-scale

0.479

High

1438279

RHOF
Rho-related GTP-binding protein RhoF

1

17

High-throughput

0.479

High

1452742

ELOV5
Very long chain fatty acid elongase 5

1

3

High-throughput

0.479

High

1459495

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

181030

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

1

0

High-throughput

0.458

High

744488

HPPD
4-hydroxyphenylpyruvate dioxygenase

1

0

Small-scale

0.458

High

995374

CSK2B
Casein kinase II subunit beta

1

0

High-throughput

0.458

High

1358047

TM171
Transmembrane protein 171

1

0

High-throughput

0.458

High

1389826

DTBP1
Dysbindin

1

0

High-throughput

0.458

High

1452941

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.458

High

212515

SPIT2
Kunitz-type protease inhibitor 2

1

3

High-throughput

0.445

High

938837

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.445

High

1053093

VMAT2
Synaptic vesicular amine transporter

1

2

High-throughput

0.445

High

1227801

A16L1
Autophagy-related protein 16-1

1

8

High-throughput

0.445

High

1234038

S35E4
Solute carrier family 35 member E4

1

3

High-throughput

0.445

High

1340531

DNJB8
DnaJ homolog subfamily B member 8

1

4

High-throughput

0.445

High

1394694

KIRR1
Kin of IRRE-like protein 1

1

2

High-throughput

0.445

High

1436672

ZDH11
Palmitoyltransferase ZDHHC11

1

1

High-throughput

0.445

High

1448679

GTR9
Solute carrier family 2, facilitated glucose transporter member 9

1

6

High-throughput

0.445

High

533807

CLUS
Clusterin

1

0

High-throughput

0.438

High

106938

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

294609

CD123
Translation initiation factor eIF2 assembly protein

1

4

High-throughput

0.437

High

590161

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

689912

FKBP2
Peptidyl-prolyl cis-trans isomerase FKBP2

1

1

Small-scale

0.437

High

697000

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

769646

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

799619

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

1241142

TATD1
Deoxyribonuclease TATDN1

1

1

High-throughput

0.437

High

1250226

LRC31
Leucine-rich repeat-containing protein 31

1

1

High-throughput

0.437

High

1256308

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1433606

RHOJ
Rho-related GTP-binding protein RhoJ

1

17

High-throughput

0.437

High

1438454

SACA1
Sperm acrosome membrane-associated protein 1

1

2

High-throughput

0.437

High

166464

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

7

High-throughput

0.407

High

1010990

BAT1
b(0,+)-type amino acid transporter 1

1

5

High-throughput

0.407

High

1211472

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.407

High

1397206

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

9

High-throughput

0.407

High

1431309

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.407

High

1449287

S22AB
Solute carrier family 22 member 11

1

2

High-throughput

0.407

High

821792

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

1391396

MRAP2
Melanocortin-2 receptor accessory protein 2

2

0

High-throughput

0.328

High

1395323

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

124549

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.279

Low

1111401

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.279

Low

1142544

PDCD1
Programmed cell death protein 1

1

0

High-throughput

0.279

Low

1462070

CLC4A
C-type lectin domain family 4 member A

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025