HitPredict

Interactor 1: NCK2 (O55033)
Cytoplasmic protein NCK2 (Growth factor receptor-bound protein 4) (NCK adaptor protein 2) (Nck-2) (SH2/SH3 adaptor protein NCK-beta)
Gene: NCK2

Interactor 2: DOK2 (O70469)
Docking protein 2 (Dok-related protein) (Dok-R) (Downstream of tyrosine kinase 2) (IL-four receptor-interacting protein) (FRIP) (p56(dok-2))
Gene: DOK2

Species: Mus musculus

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.80	0.705

Property	Details
Experiments	20697350, 10428862
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, PH~SH3_9
Common GO terms	-
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 380 Mm			1 412
+	Mm
		250957 NCK1_MOUSE (1-379): 6.37e-88: 272: 67.19		DOK2_MOUSE (1-412): 1.11e-159: 457: 100.00
+	Hs
		208960 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04
+	Hs
		235041 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		DOK2_HUMAN (4-412): 4.96e-142: 412: 74.04
+	Mm
		223011 NCK2_MOUSE (1-380): 1.59e-93: 286: 100.00		DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51
+	Hs
		209149 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11
+	Mm
		956524 NCK1_MOUSE (1-379): 6.37e-88: 272: 67.19		DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51
+	Hs
		557780 NCK1_HUMAN (1-379): 1.12e-87: 271: 66.93		DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11
+	Hs
		208999 NCK2_HUMAN (1-380): 1.15e-93: 287: 96.05		IRS1_HUMAN (4-375): 4.22e-89: 294: 16.03
+	Mm
		643076 P85A_MOUSE (24-379): 1.32e-31: 128: 12.57		DOK1_MOUSE (6-393): 3.94e-113: 341: 34.51
+	Hs
		655452 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		DOK1_HUMAN (6-394): 5.32e-111: 336: 34.11
+	Mm
		643063 P85A_MOUSE (24-379): 1.32e-31: 128: 12.57		IRS1_MOUSE (4-375): 3.64e-90: 297: 16.24
+	Rn
		724634 P85A_RAT (24-379): 1.69e-30: 124: 12.57		IRS1_RAT (4-375): 5.81e-91: 300: 16.24
+	Hs
		655240 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		IRS1_HUMAN (4-375): 4.22e-89: 294: 16.03
+	Hs
		129219 P85B_HUMAN (2-379): 2.19e-30: 124: 12.53		IRS1_HUMAN (4-375): 4.22e-89: 294: 16.03
+	Hs
		151716 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		IRS4_HUMAN (4-392): 7.12e-83: 277: 16.01
+	Hs
		129141 P85B_HUMAN (2-379): 2.19e-30: 124: 12.53		IRS4_HUMAN (4-392): 7.12e-83: 277: 16.01
+	Mm
		643075 P85A_MOUSE (24-379): 1.32e-31: 128: 12.57		IRS2_MOUSE (15-348): 9.5e-76: 257: 16.76
+	Hs
		655516 P85A_HUMAN (24-379): 4.46e-31: 126: 12.57		IRS2_HUMAN (15-348): 2.09e-75: 257: 16.89
+	Rn
		139726 P85A_RAT (24-379): 1.69e-30: 124: 12.57		O08724_RAT (15-399): 7.45e-80: 256: 16.20
+	Rn
		94391 P85A_RAT (24-379): 1.69e-30: 124: 12.57		F1MAL5_RAT (15-348): 1.6e-74: 254: 15.68