HitPredict

Interactor 1: KALRN (O60229)
Kalirin (EC 2.7.11.1) (Huntingtin-associated protein-interacting protein) (Protein Duo) (Serine/threonine-protein kinase with Dbl- and pleckstrin homology domain)
Gene: KALRN

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.768

Property	Details
Experiments	21483438, 9139723
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Ras~fn3, PH~Ras, Pkinase~Ras, Ras~RhoGEF
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2986 Hs			1 192
+	Hs
		279854 TRIO_HUMAN (23-2982): 0: 1941: 59.82		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		279855 TRIO_HUMAN (23-2982): 0: 1941: 59.82		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		279850 TRIO_HUMAN (23-2982): 0: 1941: 59.82		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		279851 TRIO_HUMAN (23-2982): 0: 1941: 59.82		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		166482 MCF2L_HUMAN (1536-2405): 1.83e-123: 423: 19.06		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		166478 MCF2L_HUMAN (1536-2405): 1.83e-123: 423: 19.06		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		166479 MCF2L_HUMAN (1536-2405): 1.83e-123: 423: 19.06		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		925405 ARHGP_HUMAN (1258-1693): 8.37e-122: 400: 30.53		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		164599 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		164564 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RHOQ_HUMAN (4-187): 4.46e-85: 251: 64.67
+	Hs
		164665 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RHOJ_HUMAN (2-189): 1.38e-80: 240: 60.64
+	Hs
		894178 ARHGP_HUMAN (1258-1693): 8.37e-122: 400: 30.53		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		164589 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RAC3_HUMAN (1-191): 2.72e-79: 236: 93.19
+	Hs
		164602 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RHOG_HUMAN (1-192): 3.1e-79: 236: 71.35
+	Hs
		164590 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		900648 ARHGP_HUMAN (1258-1693): 8.37e-122: 400: 30.53		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		164593 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Hs
		164556 SPTN2_HUMAN (97-2001): 6.12e-110: 396: 12.34		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Ce
		975576 Q7KPP4_CAEEL (825-2386): 1.47e-95: 347: 13.78		RAC1_CAEEL (1-192): 2.2e-83: 246: 82.81
+	Ce
		104468 Q7KPP4_CAEEL (825-2386): 1.47e-95: 347: 13.78		G5EBV3_CAEEL (2-192): 6.22e-78: 232: 65.45