Interactor 1: MED14 (O60244)
Mediator of RNA polymerase II transcription subunit 14 (Activator-recruited cofactor 150 kDa component) (ARC150) (Cofactor required for Sp1 transcriptional activation subunit 2) (CRSP complex subunit 2) (Mediator complex subunit 14) (RGR1 homolog) (hRGR1) (Thyroid hormone receptor-associated protein complex 170 kDa component) (Trap170) (Transcriptional coactivator CRSP150) (Vitamin D3 receptor-interacting protein complex 150 kDa component) (DRIP150)
Gene: MED14

Interactor 2: MED4 (Q9NPJ6)
Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)
Gene: MED4

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score Annotation score Interaction score
0.82 1.00 0.906

The method score is based on:

Property Details
Experiments 25281560, 24981860, 33961781, 35271311
Identification Methods proximity labelling technology, affinity chromatography technology, anti tag coimmunoprecipitation, pull down
Interaction Type physical association, association

The annotation score is based on:

Property Details
Interacting Pfam domains Med14~Med4
Common GO terms GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006357 - regulation of transcription by RNA polymerase II
and 9 others

more...

Homologous interactions 2

Homologous interactions

Color coding for hit scores

1 1454
Hs

1 270
+ Dm
+ Hs

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024