Protein: CIKS
E3 ubiquitin ligase TRAF3IP2 (EC 2.3.2.27) (Adapter protein CIKS) (Connection to IKK and SAPK/JNK) (E3 ubiquitin-protein ligase CIKS) (Nuclear factor NF-kappa-B activator 1) (ACT1) (TRAF3-interacting protein 2)

Gene: CIKS, TRAF3IP2
Organism: Homo sapiens
Interactions: 49
UniProt ID: O43734

Gene Ontology (top 5):
GO:0001768 - establishment of T cell polarity
GO:0001782 - B cell homeostasis
GO:0001783 - B cell apoptotic process
GO:0001822 - kidney development
GO:0002230 - positive regulation of defense response to virus by host

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

225427

I17RA
Interleukin-17 receptor A

6

2

Small-scale

0.935

High

225437

TRAF6
TNF receptor-associated factor 6

13

12

Small-scale

0.760

High

225395

CIKS
E3 ubiquitin ligase TRAF3IP2

2

0

Small-scale

0.728

High

225408

TRAF2
TNF receptor-associated factor 2

4

12

Small-scale

0.693

High

225416

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

4

0

High-throughput

0.661

High

225411

TRAF3
TNF receptor-associated factor 3

3

12

Small-scale

0.650

High

225438

NEMO
NF-kappa-B essential modulator

3

0

Small-scale

0.636

High

225414

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

2

5

Small-scale

0.624

High

225402

TNR5
Tumor necrosis factor receptor superfamily member 5

3

0

Small-scale

0.622

High

225422

I17RC
Interleukin-17 receptor C

1

4

Small-scale

0.618

High

225433

I17RB
Interleukin-17 receptor B

1

2

Small-scale

0.618

High

136647

TRAF5
TNF receptor-associated factor 5

2

12

Small-scale

0.611

High

213727

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

1

Small-scale

0.601

High

225406

SRSF1
Serine/arginine-rich splicing factor 1

2

0

Small-scale

0.585

High

167773

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

2

5

Small-scale

0.584

High

225435

TBK1
Serine/threonine-protein kinase TBK1

1

5

Small-scale

0.561

High

225398

HS90A
Heat shock protein HSP 90-alpha

2

0

Small-scale

0.559

High

225396

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.549

High

225417

TRIP6
Thyroid receptor-interacting protein 6

1

0

High-throughput

0.549

High

225434

RIM3A
RIMS-binding protein 3A

1

0

High-throughput

0.549

High

225432

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.541

High

225430

MDFI
MyoD family inhibitor

1

0

High-throughput

0.518

High

225420

BEX5
Protein BEX5

1

0

High-throughput

0.513

High

225431

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

High-throughput

0.513

High

225436

INVS
Inversin

1

0

High-throughput

0.513

High

225428

TR13C
Tumor necrosis factor receptor superfamily member 13C

1

0

Small-scale

0.493

High

225413

FHL3
Four and a half LIM domains protein 3

1

1

High-throughput

0.481

High

225425

TRI63
E3 ubiquitin-protein ligase TRIM63

1

1

High-throughput

0.481

High

225399

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.480

High

225412

UB2V1
Ubiquitin-conjugating enzyme E2 variant 1

1

0

Small-scale

0.480

High

177744

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

5

Small-scale

0.479

High

225400

IRF1
Interferon regulatory factor 1

1

1

Small-scale

0.479

High

225409

TRAF1
TNF receptor-associated factor 1

1

12

Small-scale

0.479

High

225415

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

225426

Q96C98
FHL3 protein

1

1

High-throughput

0.470

High

225429

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

225397

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

225401

CEBPB
CCAAT/enhancer-binding protein beta

1

0

Small-scale

0.458

High

225403

HSP74
Heat shock 70 kDa protein 4

1

0

Small-scale

0.458

High

225404

KSYK
Tyrosine-protein kinase SYK

1

0

Small-scale

0.458

High

225405

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.458

High

225418

ELAV1
ELAV-like protein 1

1

0

Small-scale

0.458

High

225419

IL17
Interleukin-17A

1

0

Small-scale

0.458

High

225423

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

225410

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.299

High

225421

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.279

Low

225424

DNJB3
DnaJ homolog subfamily B member 3

1

0

High-throughput

0.279

Low

225407

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.265

Low


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Last updated: 11Aug2025