HitPredict

Interactor 1: KLK8 (O60259)
Kallikrein-8 (hK8) (EC 3.4.21.118) (Neuropsin) (NP) (Ovasin) (Serine protease 19) (Serine protease TADG-14) (Tumor-associated differentially expressed gene 14 protein)
Gene: KLK8

Interactor 2: NT2NA (Q7Z3S9)
Notch homolog 2 N-terminal-like protein A (Notch homolog 2 N-terminal-like protein)
Gene: NOTCH2NLA

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.66	1.00	0.817

Property	Details
Experiments	25416956, 32296183
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	EGF~Trypsin
Common GO terms	GO:0005576 - extracellular region GO:0005737 - cytoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 260 Hs			1 236
+	Hs
		225950 KLK8_HUMAN (1-260): 8.28e-126: 359: 100.00		NT2NC_HUMAN (69-233): 8.71e-14: 70.8: 32.95
+	Hs
		1055020 KLK11_HUMAN (30-259): 6.41e-107: 312: 50.43		FAT1_HUMAN (138-236): 1.66e-24: 103: 28.43
+	Hs
		589611 KLK2_HUMAN (12-259): 1.45e-106: 310: 41.63		JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86
+	Hs
		1055016 TMPS4_HUMAN (6-259): 1.55e-93: 283: 31.46		FAT1_HUMAN (138-236): 1.66e-24: 103: 28.43
+	Hs
		1329638 KLK15_HUMAN (23-259): 7.94e-100: 293: 45.57		JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86
+	Hs
		980580 KLK5_HUMAN (24-259): 1.95e-97: 288: 47.48		NOTC2_HUMAN (8-180): 9.42e-16: 78.1: 27.84
+	Hs
		1345092 TMPS4_HUMAN (6-259): 1.55e-93: 283: 31.46		JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86
+	Mm
		378815 GRAB_MOUSE (26-259): 1.44e-89: 266: 35.27		NOTC1_MOUSE (69-234): 8.14e-17: 81.2: 31.25
+	Hs
		296677 TMPS4_HUMAN (6-259): 1.55e-93: 283: 31.46		SLIT2_HUMAN (68-185): 2.64e-10: 62: 32.52
+	Mm
		94698 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		F2Z4A3_MOUSE (148-236): 1.73e-23: 100: 29.35
+	Hs
		621366 CMA1_HUMAN (26-256): 1.08e-39: 139: 36.67		FAT1_HUMAN (138-236): 1.66e-24: 103: 28.43
+	Mm
		192824 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		NOTC2_MOUSE (8-207): 3.96e-15: 76.2: 25.62
+	Hs
		486154 GRAB_HUMAN (27-256): 1.37e-39: 139: 37.08		NOTC1_HUMAN (67-233): 4.88e-17: 81.9: 29.94
+	Mm
		372013 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		SNED1_MOUSE (12-144): 8.13e-12: 66.2: 33.33
+	Hs
		621387 CMA1_HUMAN (26-256): 1.08e-39: 139: 36.67		JAG2_HUMAN (8-209): 1.76e-16: 80.1: 31.86
+	Mm
		372668 CFAD_MOUSE (15-255): 5.96e-45: 153: 38.65		SLIT2_MOUSE (67-185): 4.42e-09: 58.1: 30.65
+	Hs
		621373 CMA1_HUMAN (26-256): 1.08e-39: 139: 36.67		FAT4_HUMAN (5-97): 1.2e-11: 65.8: 23.53