Protein: CLCN7
H(+)/Cl(-) exchange transporter 7 (Chloride channel 7 alpha subunit) (Chloride channel protein 7) (ClC-7)

Gene: CLCN7
Organism: Homo sapiens
Interactions: 163
UniProt ID: P51798

Gene Ontology (top 5):
GO:0005254 - chloride channel activity
GO:0005524 - ATP binding
GO:0005765 - lysosomal membrane
GO:0009268 - response to pH
GO:0015108 - chloride transmembrane transporter activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

907811

OSTM1
Osteopetrosis-associated transmembrane protein 1

6

1

Small-scale

0.949

High

127304

LEG8
Galectin-8

3

9

High-throughput

0.667

High

220482

RNF13
E3 ubiquitin-protein ligase RNF13

3

0

High-throughput

0.638

High

907823

MCLN3
Mucolipin-3

3

0

High-throughput

0.638

High

900734

RAB5C
Ras-related protein Rab-5C

2

2

High-throughput

0.611

High

332625

LYPD3
Ly6/PLAUR domain-containing protein 3

3

1

High-throughput

0.609

High

907865

LYVE1
Lymphatic vessel endothelial hyaluronic acid receptor 1

2

1

High-throughput

0.606

High

907786

VAC14
Protein VAC14 homolog

2

0

High-throughput

0.602

High

907844

MANS1
MANSC domain-containing protein 1

2

0

High-throughput

0.602

High

907817

S15A4
Solute carrier family 15 member 4

2

1

High-throughput

0.588

High

907779

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.586

High

385574

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

3

2

High-throughput

0.586

High

373849

RASN
GTPase NRas

2

5

High-throughput

0.584

High

375307

RASK
GTPase KRas

2

5

High-throughput

0.584

High

907815

S66A2
Solute carrier family 66 member 2

2

0

High-throughput

0.580

High

907822

GDAP1
Ganglioside-induced differentiation-associated protein 1

2

0

High-throughput

0.580

High

907830

TLCD4
TLC domain-containing protein 4

2

0

High-throughput

0.580

High

907852

S38A7
Sodium-coupled neutral amino acid transporter 7

2

0

High-throughput

0.580

High

591250

CD44
CD44 antigen

2

1

High-throughput

0.574

High

417335

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

0

High-throughput

0.559

High

770835

OPRM
Mu-type opioid receptor

2

1

High-throughput

0.553

High

907806

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.553

High

138815

STK25
Serine/threonine-protein kinase 25

1

1

High-throughput

0.536

High

555967

CADH1
Cadherin-1

1

2

High-throughput

0.536

High

901744

RAB9A
Ras-related protein Rab-9A

2

5

High-throughput

0.533

High

907781

RHOB
Rho-related GTP-binding protein RhoB

2

9

High-throughput

0.533

High

845567

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.517

High

133470

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.513

High

208987

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

219939

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

292592

RENR
Renin receptor

1

0

High-throughput

0.513

High

380270

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.513

High

536244

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.513

High

907774

CTXN1
Cortexin-1

1

0

High-throughput

0.513

High

907797

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.513

High

907841

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

907862

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

230287

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.508

High

907795

GLE1
mRNA export factor GLE1

1

0

High-throughput

0.493

High

248465

O10H2
Olfactory receptor 10H2

1

1

High-throughput

0.489

High

907793

LEG9B
Galectin-9B

1

9

High-throughput

0.489

High

907796

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.489

High

907864

PCDGL
Protocadherin gamma-C4

1

1

High-throughput

0.489

High

907773

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.481

High

178220

NPC1
NPC intracellular cholesterol transporter 1

1

1

High-throughput

0.479

High

179852

BET1
BET1 homolog

1

1

High-throughput

0.479

High

189468

STX7
Syntaxin-7

1

1

High-throughput

0.479

High

540369

LAMP1
Lysosome-associated membrane glycoprotein 1

1

2

High-throughput

0.479

High

560334

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

561960

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

631131

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.479

High

634367

LMNB1
Lamin-B1

1

2

High-throughput

0.479

High

901136

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.479

High

907776

CDC42
Cell division control protein 42 homolog

1

9

High-throughput

0.479

High

907777

RAB2A
Ras-related protein Rab-2A

1

2

High-throughput

0.479

High

907782

RAC1
Ras-related C3 botulinum toxin substrate 1

1

8

High-throughput

0.479

High

907784

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

907787

STX4
Syntaxin-4

1

1

High-throughput

0.479

High

907825

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.479

High

907833

SEC62
Translocation protein SEC62

1

1

High-throughput

0.479

High

907842

DNJC5
DnaJ homolog subfamily C member 5

1

1

High-throughput

0.479

High

907850

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.479

High

907859

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

907860

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

907861

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.479

High

907803

Q6P5T0
AQP7 protein

1

3

High-throughput

0.470

High

173890

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

291266

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.458

High

418029

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

580608

AMPN
Aminopeptidase N

1

0

High-throughput

0.458

High

692895

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

847480

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880492

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

884295

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.458

High

894640

EMD
Emerin

1

0

High-throughput

0.458

High

903845

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

907769

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.458

High

907772

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

907785

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

907792

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

907799

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.458

High

907818

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

907827

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.458

High

907832

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

907838

DERL1
Derlin-1

1

0

High-throughput

0.458

High

907847

ABCB6
ATP-binding cassette sub-family B member 6

1

0

High-throughput

0.458

High

907848

PLPL8
Calcium-independent phospholipase A2-gamma

1

0

High-throughput

0.458

High

907849

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

907854

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

907856

TM216
Transmembrane protein 216

1

0

High-throughput

0.458

High

907857

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

388390

B3AT
Band 3 anion transport protein

1

1

High-throughput

0.445

High

609629

LEG3
Galectin-3

1

9

High-throughput

0.445

High

638399

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.445

High

907801

MFS12
Major facilitator superfamily domain-containing protein 12

1

1

High-throughput

0.445

High

907802

NPAL3
NIPA-like protein 3

1

1

High-throughput

0.445

High

907820

S38A9
Neutral amino acid transporter 9

1

1

High-throughput

0.445

High

907824

MOT10
Monocarboxylate transporter 10

1

1

High-throughput

0.445

High

907837

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

1

High-throughput

0.445

High

907839

S46A2
Solute carrier family 46 member 2

1

1

High-throughput

0.445

High

155381

AQP7
Aquaporin-7

1

3

High-throughput

0.439

High

126516

RHOD
Rho-related GTP-binding protein RhoD

1

12

High-throughput

0.437

High

188841

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.437

High

225967

STX6
Syntaxin-6

1

1

High-throughput

0.437

High

466162

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.437

High

580941

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.437

High

601215

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.437

High

630479

RAB3B
Ras-related protein Rab-3B

1

1

High-throughput

0.437

High

630731

RAB4A
Ras-related protein Rab-4A

1

2

High-throughput

0.437

High

907770

RND2
Rho-related GTP-binding protein RhoN

1

11

High-throughput

0.437

High

907775

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.437

High

907778

RHOA
Transforming protein RhoA

1

8

High-throughput

0.437

High

907783

RHOG
Rho-related GTP-binding protein RhoG

1

7

High-throughput

0.437

High

907790

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.437

High

907791

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.437

High

907807

RHOU
Rho-related GTP-binding protein RhoU

1

11

High-throughput

0.437

High

907810

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

907843

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.437

High

907845

RHOF
Rho-related GTP-binding protein RhoF

1

10

High-throughput

0.437

High

907863

MTCL1
Microtubule cross-linking factor 1

1

1

High-throughput

0.437

High

907853

SL2A8
Solute carrier family 2, facilitated glucose transporter member 8

1

0

High-throughput

0.426

High

907855

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

0

High-throughput

0.426

High

704001

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

907788

UT1
Urea transporter 1

1

1

High-throughput

0.407

High

907813

F177A
Protein FAM177A1

3

0

High-throughput

0.347

High

907826

BIRC7
Baculoviral IAP repeat-containing protein 7

3

0

High-throughput

0.347

High

829892

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.328

High

907798

MBLC2
Acyl-coenzyme A thioesterase MBLAC2

2

0

High-throughput

0.328

High

129860

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

622037

CD53
Leukocyte surface antigen CD53

2

0

High-throughput

0.316

High

907809

T179B
Transmembrane protein 179B

2

0

High-throughput

0.316

High

907821

LHPL5
LHFPL tetraspan subfamily member 5 protein

2

0

High-throughput

0.316

High

907858

KCNN3
Small conductance calcium-activated potassium channel protein 3

2

0

High-throughput

0.316

High

127654

TR10A
Tumor necrosis factor receptor superfamily member 10A

1

0

High-throughput

0.279

Low

907771

BIEA
Biliverdin reductase A

1

0

High-throughput

0.279

Low

907794

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

907804

SAMD1
Sterile alpha motif domain-containing protein 1

1

0

High-throughput

0.279

Low

907805

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.279

Low

907829

TET5A
Terminal nucleotidyltransferase 5A

1

0

High-throughput

0.279

Low

907835

TMM47
Transmembrane protein 47

1

0

High-throughput

0.279

Low

907846

RXFP1
Relaxin receptor 1

1

0

High-throughput

0.279

Low

907808

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

181695

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low

217982

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

377467

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

413447

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

715493

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.249

Low

833451

WNT5A
Protein Wnt-5a

1

0

High-throughput

0.249

Low

907780

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.249

Low

907789

INSL4
Early placenta insulin-like peptide

1

0

High-throughput

0.249

Low

907800

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

907812

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

907814

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

907819

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

907828

RBM33
RNA-binding protein 33

1

0

High-throughput

0.249

Low

907831

ZN285
Zinc finger protein 285

1

0

High-throughput

0.249

Low

907834

SCAFB
Protein SCAF11

1

0

High-throughput

0.249

Low

907836

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.249

Low

907840

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.249

Low

907851

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

190334

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.232

Low

653204

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

907816

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025