HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HNRPQ (O60506)
Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)
Gene: SYNCRIP

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35256949, 24244333
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 623
+	Hs
		201998 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HNRPR_HUMAN (3-623): 8.08e-111: 348: 77.09
+	Hs
		235639 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HNRPQ_HUMAN (1-623): 4.45e-141: 425: 100.00
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (152-621): 1.53e-53: 195: 17.26
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (152-609): 3.29e-52: 191: 16.08
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (152-612): 5.9e-50: 185: 16.29
+	Hs
		202014 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HNRPR_HUMAN (3-623): 8.08e-111: 348: 77.09
+	Hs
		235679 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HNRPQ_HUMAN (1-623): 4.45e-141: 425: 100.00
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (47-232): 1.22e-18: 91.9: 15.15
+	Hs
		202036 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HNRPR_HUMAN (3-623): 8.08e-111: 348: 77.09
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (152-621): 1.53e-53: 195: 17.26
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (152-609): 3.29e-52: 191: 16.08
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (162-621): 1.23e-55: 201: 14.63
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (152-621): 1.53e-53: 195: 17.26
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (152-609): 3.29e-52: 191: 16.08
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (160-621): 2.75e-46: 175: 14.23