Protein: EPHA4
Ephrin type-A receptor 4 (EC 2.7.10.1) (EPH-like kinase 8) (EK8) (hEK8) (Tyrosine-protein kinase TYRO1) (Tyrosine-protein kinase receptor SEK)

Gene: EPHA4
Organism: Homo sapiens
Interactions: 217
UniProt ID: P54764

Gene Ontology (top 5):
GO:0001540 - amyloid-beta binding
GO:0004672 - protein kinase activity
GO:0004713 - protein tyrosine kinase activity
GO:0005004 - GPI-linked ephrin receptor activity
GO:0005005 - transmembrane-ephrin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

932078

EFNB3
Ephrin-B3

4

20

Small-scale

0.902

High

932127

TBB2B
Tubulin beta-2B chain

4

11

High-throughput

0.899

High

914527

EFNA5
Ephrin-A5

4

20

Small-scale

0.893

High

932159

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

3

19

High-throughput

0.861

High

914227

EFNA4
Ephrin-A4

3

20

Small-scale

0.853

High

457332

TBB5
Tubulin beta chain

2

11

High-throughput

0.811

High

932074

EPHA7
Ephrin type-A receptor 7

2

20

High-throughput

0.811

High

408010

TBB4A
Tubulin beta-4A chain

2

11

High-throughput

0.798

High

761197

RYK
Tyrosine-protein kinase RYK

2

20

Small-scale

0.789

High

932081

CEA21
Cell adhesion molecule CEACAM21

3

10

High-throughput

0.770

High

635249

EFNA1
Ephrin-A1

2

20

Small-scale

0.768

High

231304

EFNA2
Ephrin-A2

1

20

Small-scale

0.761

High

914389

EFNB2
Ephrin-B2

1

20

Small-scale

0.761

High

375322

RASK
GTPase KRas

2

20

High-throughput

0.754

High

541411

FGFR1
Fibroblast growth factor receptor 1

2

20

Small-scale

0.754

High

710142

EPHA2
Ephrin type-A receptor 2

2

19

High-throughput

0.754

High

440462

FYN
Tyrosine-protein kinase Fyn

2

19

Small-scale

0.743

High

699663

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

2

20

High-throughput

0.743

High

840938

ABL2
Tyrosine-protein kinase ABL2

2

20

High-throughput

0.743

High

650101

FGFR3
Fibroblast growth factor receptor 3

1

18

Small-scale

0.740

High

62107

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

12

High-throughput

0.726

High

710799

EPHB2
Ephrin type-B receptor 2

1

18

High-throughput

0.715

High

596467

CTLA4
Cytotoxic T-lymphocyte protein 4

1

2

High-throughput

0.691

High

710614

EPHA3
Ephrin type-A receptor 3

1

18

High-throughput

0.691

High

932054

TBB4B
Tubulin beta-4B chain

1

11

High-throughput

0.691

High

932067

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

16

High-throughput

0.691

High

932079

CDC37
Hsp90 co-chaperone Cdc37

1

20

High-throughput

0.691

High

252671

TSN3
Tetraspanin-3

3

7

High-throughput

0.667

High

618446

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

3

7

High-throughput

0.667

High

557189

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.647

High

932047

EPHA4
Ephrin type-A receptor 4

1

19

Small-scale

0.647

High

932134

SLAP2
Src-like-adapter 2

1

20

Small-scale

0.647

High

932126

TBB6
Tubulin beta-6 chain

1

11

High-throughput

0.646

High

932151

GPN3
GPN-loop GTPase 3

4

1

High-throughput

0.635

High

932111

HDA10
Polyamine deacetylase HDAC10

2

2

High-throughput

0.628

High

932117

GBP5
Guanylate-binding protein 5

2

2

High-throughput

0.628

High

932142

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

5

High-throughput

0.628

High

932087

TENS3
Tensin-3

1

18

High-throughput

0.625

High

539047

UMPS
Uridine 5'-monophosphate synthase

2

1

High-throughput

0.621

High

410736

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.621

High

136346

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.618

High

168659

CSKP
Peripheral plasma membrane protein CASK

1

20

High-throughput

0.618

High

222044

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.618

High

296472

STAM2
Signal transducing adapter molecule 2

1

20

High-throughput

0.618

High

324286

ARHGF
Rho guanine nucleotide exchange factor 15

1

20

Small-scale

0.618

High

348081

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.618

High

374500

RASH
GTPase HRas

1

20

High-throughput

0.618

High

461311

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

463419

LYN
Tyrosine-protein kinase Lyn

1

19

High-throughput

0.618

High

468218

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

627512

DPA1
HLA class II histocompatibility antigen, DP alpha 1 chain

1

15

High-throughput

0.618

High

641143

FGFR2
Fibroblast growth factor receptor 2

1

20

Small-scale

0.618

High

648471

FGFR4
Fibroblast growth factor receptor 4

1

20

Small-scale

0.618

High

711287

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.618

High

855839

CRKL
Crk-like protein

1

20

High-throughput

0.618

High

932053

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.618

High

932057

NOTC2
Neurogenic locus notch homolog protein 2

1

13

High-throughput

0.618

High

932058

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

20

High-throughput

0.618

High

932061

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

20

High-throughput

0.618

High

932062

DLG1
Disks large homolog 1

1

18

High-throughput

0.618

High

932066

GAB1
GRB2-associated-binding protein 1

1

20

High-throughput

0.618

High

932091

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.618

High

932098

UNC5B
Netrin receptor UNC5B

1

16

High-throughput

0.618

High

932100

NGEF
Ephexin-1

1

20

Small-scale

0.618

High

932104

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.618

High

932112

FERM2
Fermitin family homolog 2

1

6

High-throughput

0.618

High

932119

ERBIN
Erbin

1

20

High-throughput

0.618

High

932137

PKHA1
Pleckstrin homology domain-containing family A member 1

1

20

High-throughput

0.618

High

932138

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.618

High

932139

WDR6
tRNA

1

16

High-throughput

0.618

High

932143

LIN7C
Protein lin-7 homolog C

1

20

High-throughput

0.618

High

932150

BI2L1
BAR/IMD domain-containing adapter protein 2-like 1

1

19

High-throughput

0.618

High

932155

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

10

High-throughput

0.618

High

932106

TB22A
TBC1 domain family member 22A

3

10

High-throughput

0.609

High

769686

RFC4
Replication factor C subunit 4

2

0

High-throughput

0.602

High

208641

SI1L1
Signal-induced proliferation-associated 1-like protein 1

1

6

High-throughput

0.590

High

326852

RIMB1
Peripheral-type benzodiazepine receptor-associated protein 1

1

8

High-throughput

0.590

High

599278

PLCG2
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2

1

13

High-throughput

0.590

High

619015

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

13

High-throughput

0.590

High

631833

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

8

High-throughput

0.590

High

635700

RASA1
Ras GTPase-activating protein 1

1

20

High-throughput

0.590

High

907260

STA5B
Signal transducer and activator of transcription 5B

1

12

High-throughput

0.590

High

913632

VAV2
Guanine nucleotide exchange factor VAV2

1

20

High-throughput

0.590

High

932063

GRB10
Growth factor receptor-bound protein 10

1

20

High-throughput

0.590

High

932073

NR1D2
Nuclear receptor subfamily 1 group D member 2

1

10

High-throughput

0.590

High

932090

KCC1B
Calcium/calmodulin-dependent protein kinase type 1B

1

6

High-throughput

0.590

High

932093

MAGI2
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 2

1

20

High-throughput

0.590

High

932103

LNX1
E3 ubiquitin-protein ligase LNX

1

20

High-throughput

0.590

High

932105

FRS2
Fibroblast growth factor receptor substrate 2

2

11

Small-scale

0.584

High

425986

CP1A2
Cytochrome P450 1A2

2

16

High-throughput

0.574

High

932065

OS9
Protein OS-9

2

3

High-throughput

0.574

High

932089

ARMC6
Armadillo repeat-containing protein 6

2

1

High-throughput

0.574

High

932108

CBPA5
Carboxypeptidase A5

2

8

High-throughput

0.574

High

932124

F118B
Protein FAM118B

2

1

High-throughput

0.574

High

932149

RSP14
Radial spoke head 14 homolog

2

20

High-throughput

0.574

High

450476

FABPL
Fatty acid-binding protein, liver

2

1

High-throughput

0.567

High

932122

RNF5
E3 ubiquitin-protein ligase RNF5

1

7

Small-scale

0.561

High

932161

NEMO
NF-kappa-B essential modulator

1

15

High-throughput

0.561

High

932109

ESR2
Estrogen receptor beta

1

12

High-throughput

0.553

High

270204

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

20

High-throughput

0.536

High

295570

CIB2
Calcium and integrin-binding family member 2

1

4

High-throughput

0.536

High

366574

CFAB
Complement factor B

1

19

High-throughput

0.536

High

600603

NAGAB
Alpha-N-acetylgalactosaminidase

1

3

High-throughput

0.536

High

844997

EAA3
Excitatory amino acid transporter 3

1

14

High-throughput

0.536

High

932071

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

7

High-throughput

0.536

High

932160

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

1

High-throughput

0.536

High

692674

CALL3
Calmodulin-like protein 3

1

0

High-throughput

0.513

High

227838

MYO1B
Unconventional myosin-Ib

1

13

High-throughput

0.500

High

285622

BAF
Barrier-to-autointegration factor

1

6

High-throughput

0.500

High

475932

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

7

High-throughput

0.500

High

932052

RS29
Small ribosomal subunit protein uS14

1

1

High-throughput

0.500

High

932125

NTPCR
Cancer-related nucleoside-triphosphatase

1

9

High-throughput

0.500

High

932128

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.500

High

932144

FANCI
Fanconi anemia group I protein

1

4

High-throughput

0.500

High

848463

MAGA8
Melanoma-associated antigen 8

1

5

High-throughput

0.489

High

932051

COPZ1
Coatomer subunit zeta-1

1

4

High-throughput

0.489

High

932060

LR74A
Leucine-rich repeat-containing protein 74A

1

20

High-throughput

0.489

High

932082

NHLC3
NHL repeat-containing protein 3

1

1

High-throughput

0.489

High

932145

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

1

High-throughput

0.489

High

105640

APRIO
Alternative prion protein

1

2

High-throughput

0.479

High

169490

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

20

High-throughput

0.479

High

218004

TGON2
Trans-Golgi network integral membrane protein 2

1

13

High-throughput

0.479

High

229989

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

6

High-throughput

0.479

High

254097

CTND1
Catenin delta-1

1

20

High-throughput

0.479

High

293426

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.479

High

299954

CBPD
Carboxypeptidase D

1

8

High-throughput

0.479

High

336084

ZFYV9
Zinc finger FYVE domain-containing protein 9

1

20

High-throughput

0.479

High

338594

AGRL2
Adhesion G protein-coupled receptor L2

1

10

High-throughput

0.479

High

343337

SNP29
Synaptosomal-associated protein 29

1

5

High-throughput

0.479

High

540378

LAMP1
Lysosome-associated membrane glycoprotein 1

1

10

High-throughput

0.479

High

577676

PLAK
Junction plakoglobin

1

20

High-throughput

0.479

High

603906

CXA1
Gap junction alpha-1 protein

1

14

High-throughput

0.479

High

618231

CADH2
Cadherin-2

1

20

High-throughput

0.479

High

618497

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

7

High-throughput

0.479

High

684484

CTNA2
Catenin alpha-2

1

7

High-throughput

0.479

High

764288

CTNA1
Catenin alpha-1

1

7

High-throughput

0.479

High

889233

NUMB
Protein numb homolog

1

19

High-throughput

0.479

High

932048

S12A2
Solute carrier family 12 member 2

1

7

High-throughput

0.479

High

932055

DSC2
Desmocollin-2

1

20

High-throughput

0.479

High

932056

CAV1
Caveolin-1

1

10

High-throughput

0.479

High

932059

FCHO2
F-BAR domain only protein 2

1

11

High-throughput

0.479

High

932069

DSG2
Desmoglein-2

1

20

High-throughput

0.479

High

932070

FLOT2
Flotillin-2

1

13

High-throughput

0.479

High

932077

AAAT
Neutral amino acid transporter B(0)

1

14

High-throughput

0.479

High

932080

OCLN
Occludin

1

5

High-throughput

0.479

High

932085

F1711
Protein FAM171A1

1

12

High-throughput

0.479

High

932092

ZFY16
Zinc finger FYVE domain-containing protein 16

1

20

High-throughput

0.479

High

932094

LSR
Lipolysis-stimulated lipoprotein receptor

1

4

High-throughput

0.479

High

932095

CPNE8
Copine-8

1

5

High-throughput

0.479

High

932096

DEN6A
Protein DENND6A

1

1

High-throughput

0.479

High

932101

CNNM3
Metal transporter CNNM3

1

3

High-throughput

0.479

High

932102

VANG1
Vang-like protein 1

1

4

High-throughput

0.479

High

932110

US6NL
USP6 N-terminal-like protein

1

12

High-throughput

0.479

High

932113

CYFP2
Cytoplasmic FMR1-interacting protein 2

1

9

High-throughput

0.479

High

932120

NIBA2
Protein Niban 2

1

6

High-throughput

0.479

High

932121

PKP4
Plakophilin-4

1

20

High-throughput

0.479

High

932123

PKP2
Plakophilin-2

1

20

High-throughput

0.479

High

932129

ZDHC5
Palmitoyltransferase ZDHHC5

1

7

High-throughput

0.479

High

932131

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

6

High-throughput

0.479

High

932141

TMPS4
Transmembrane protease serine 4

1

18

High-throughput

0.479

High

932146

DIP2B
Disco-interacting protein 2 homolog B

1

10

High-throughput

0.479

High

932148

TRM7
tRNA

1

7

High-throughput

0.479

High

932153

ANC2
Anaphase-promoting complex subunit 2

1

4

Small-scale

0.479

High

932154

FZR1
Fizzy-related protein homolog

1

4

Small-scale

0.479

High

932156

BAIP2
BAR/IMD domain-containing adapter protein 2

1

19

High-throughput

0.479

High

932157

NCKP1
Nck-associated protein 1

1

2

High-throughput

0.479

High

932158

NISCH
Nischarin

1

20

High-throughput

0.479

High

932162

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

5

High-throughput

0.479

High

391010

TRFL
Lactotransferrin

1

0

High-throughput

0.458

High

399955

CATA
Catalase

1

0

High-throughput

0.458

High

822550

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.458

High

123355

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

1

High-throughput

0.457

High

323257

TRI37
E3 ubiquitin-protein ligase TRIM37

1

13

High-throughput

0.457

High

620226

NUCL
Nucleolin

1

10

High-throughput

0.457

High

685137

PAX6
Paired box protein Pax-6

1

6

High-throughput

0.457

High

870818

GLRB
Glycine receptor subunit beta

1

2

High-throughput

0.457

High

932084

K1755
Uncharacterized protein KIAA1755

1

9

High-throughput

0.457

High

932116

OPALI
Opalin

1

1

High-throughput

0.457

High

932130

RHG39
Rho GTPase-activating protein 39

1

11

High-throughput

0.457

High

932135

MB12B
Multivesicular body subunit 12B

1

1

High-throughput

0.457

High

829325

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

10

High-throughput

0.457

High

254907

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

14

High-throughput

0.445

High

388393

B3AT
Band 3 anion transport protein

1

11

High-throughput

0.445

High

876420

EAA4
Excitatory amino acid transporter 4

1

14

High-throughput

0.445

High

932064

UT1
Urea transporter 1

1

2

High-throughput

0.445

High

932068

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

932099

S39AB
Zinc transporter ZIP11

1

8

High-throughput

0.445

High

932118

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

19

High-throughput

0.445

High

932072

SLBP
Histone RNA hairpin-binding protein

1

0

High-throughput

0.438

High

932152

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.438

High

71305

F1712
Protein FAM171A2

1

12

High-throughput

0.437

High

179857

BET1
BET1 homolog

1

5

High-throughput

0.437

High

338304

SC24A
Protein transport protein Sec24A

1

20

High-throughput

0.437

High

338446

SC24B
Protein transport protein Sec24B

1

20

High-throughput

0.437

High

389722

FETUA
Alpha-2-HS-glycoprotein

1

7

High-throughput

0.437

High

446393

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.437

High

888691

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

6

High-throughput

0.437

High

932075

SC23A
Protein transport protein Sec23A

1

20

High-throughput

0.437

High

932076

SC23B
Protein transport protein Sec23B

1

20

High-throughput

0.437

High

932097

M21D2
Nucleotidyltransferase MB21D2

1

3

High-throughput

0.437

High

932107

BRK1
Protein BRICK1

1

3

High-throughput

0.437

High

932114

SAHH3
Adenosylhomocysteinase 3

1

6

High-throughput

0.437

High

932132

GCP60
Golgi resident protein GCP60

1

9

High-throughput

0.437

High

932136

GORS2
Golgi reassembly-stacking protein 2

1

10

High-throughput

0.437

High

932147

F135A
Protein FAM135A

1

5

High-throughput

0.437

High

932163

WASF2
Actin-binding protein WASF2

1

17

High-throughput

0.437

High

472549

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

11

High-throughput

0.417

High

932049

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.417

High

932083

GASP1
G-protein coupled receptor-associated sorting protein 1

1

2

High-throughput

0.417

High

932086

JKIP3
Janus kinase and microtubule-interacting protein 3

1

10

High-throughput

0.417

High

932088

PLAG1
Zinc finger protein PLAG1

1

5

High-throughput

0.417

High

932115

ZN521
Zinc finger protein 521

1

4

High-throughput

0.417

High

932140

MMP26
Matrix metalloproteinase-26

2

0

High-throughput

0.328

High

932133

CENPH
Centromere protein H

1

0

High-throughput

0.279

Low

391731

STAT
Statherin

1

0

High-throughput

0.249

Low

932050

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025