HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ABL1 (P00519)
Tyrosine-protein kinase ABL1 (EC 2.7.10.2) (Abelson murine leukemia viral oncogene homolog 1) (Abelson tyrosine-protein kinase 1) (Proto-oncogene c-Abl) (p150)
Gene: ABL1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	1.00	0.886

The method score is based on:

Property	Details
Experiments	35509820, 20823226, 21209200
Identification Methods	affinity chromatography technology, pull down, enzymatic study
Interaction Type	physical association, direct interaction

The annotation score is based on:

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0006979 - response to oxidative stress and 8 others more... GO:0010506 - regulation of autophagy GO:0017124 - SH3 domain binding GO:0034599 - cellular response to oxidative stress GO:0034976 - response to endoplasmic reticulum stress GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0045944 - positive regulation of transcription by RNA polymerase II GO:0048471 - perinuclear region of cytoplasm GO:1903351 - cellular response to dopamine
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1	465
Hs

1	1130

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024