Protein: SC6A8
Sodium- and chloride-dependent creatine transporter 1 (CT1) (Creatine transporter 1) (Solute carrier family 6 member 8)

Gene: SC6A8, SLC6A8
Organism: Homo sapiens
Interactions: 204
UniProt ID: P48029

Gene Ontology (top 5):
GO:0005308 - creatine transmembrane transporter activity
GO:0005309 - creatine:sodium symporter activity
GO:0005332 - gamma-aminobutyric acid:sodium:chloride symporter activity
GO:0005886 - plasma membrane
GO:0006600 - creatine metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

720651

AGTR1
Type-1 angiotensin II receptor

3

4

High-throughput

0.667

High

869685

OCAD1
OCIA domain-containing protein 1

3

3

High-throughput

0.643

High

639362

5NTD
5'-nucleotidase

3

0

High-throughput

0.638

High

327191

ZFPL1
Zinc finger protein-like 1

3

2

Small-scale

0.633

High

720599

GRPR
Gastrin-releasing peptide receptor

2

1

High-throughput

0.628

High

869665

YIPF3
Protein YIPF3

2

5

High-throughput

0.628

High

820605

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

845559

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.618

High

869580

CXAR
Coxsackievirus and adenovirus receptor

1

4

High-throughput

0.618

High

698471

CALX
Calnexin

2

17

Small-scale

0.611

High

845500

PI2R
Prostacyclin receptor

2

0

High-throughput

0.602

High

869615

TPRA1
Transmembrane protein adipocyte-associated 1

2

0

High-throughput

0.602

High

50509

HACL2
2-hydroxyacyl-CoA lyase 2

2

2

High-throughput

0.601

High

217945

TGON2
Trans-Golgi network integral membrane protein 2

2

3

High-throughput

0.584

High

373828

RASN
GTPase NRas

2

20

High-throughput

0.584

High

375282

RASK
GTPase KRas

2

20

High-throughput

0.584

High

869570

SC61B
Protein transport protein Sec61 subunit beta

2

2

High-throughput

0.584

High

869578

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

869560

S6A12
Sodium- and chloride-dependent betaine transporter

1

9

High-throughput

0.575

High

869561

S6A11
Sodium- and chloride-dependent GABA transporter 3

1

9

High-throughput

0.575

High

869682

S6A13
Sodium- and chloride-dependent GABA transporter 2

1

9

High-throughput

0.575

High

603882

CXA1
Gap junction alpha-1 protein

2

4

High-throughput

0.571

High

609619

LEG3
Galectin-3

2

8

Small-scale

0.571

High

869586

KDSR
3-ketodihydrosphingosine reductase

2

10

Small-scale

0.571

High

869596

TRAM1
Translocating chain-associated membrane protein 1

2

13

Small-scale

0.571

High

869627

T161B
Transmembrane protein 161B

2

3

Small-scale

0.571

High

869633

LMBR1
Limb region 1 protein homolog

2

2

Small-scale

0.571

High

869640

CDS1
Phosphatidate cytidylyltransferase 1

2

3

Small-scale

0.571

High

869658

CHP1
Calcineurin B homologous protein 1

2

4

Small-scale

0.571

High

869664

LNP
Endoplasmic reticulum junction formation protein lunapark

2

3

Small-scale

0.571

High

869671

FZD8
Frizzled-8

2

2

Small-scale

0.571

High

869677

SEC12
Guanine nucleotide-exchange factor SEC12

2

2

Small-scale

0.571

High

869686

T161A
Transmembrane protein 161A

2

3

Small-scale

0.571

High

869699

UBIA1
UbiA prenyltransferase domain-containing protein 1

2

2

Small-scale

0.571

High

869700

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

3

Small-scale

0.571

High

869662

G6PC3
Glucose-6-phosphatase 3

2

0

Small-scale

0.547

High

477157

ACM5
Muscarinic acetylcholine receptor M5

1

3

High-throughput

0.541

High

858188

BKRB1
B1 bradykinin receptor

1

2

High-throughput

0.541

High

164907

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

4

High-throughput

0.536

High

341404

CDS2
Phosphatidate cytidylyltransferase 2

1

3

High-throughput

0.536

High

638397

FPR1
fMet-Leu-Phe receptor

1

4

High-throughput

0.536

High

640372

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

3

High-throughput

0.536

High

668978

FPR2
N-formyl peptide receptor 2

1

4

High-throughput

0.536

High

723674

NTR1
Neurotensin receptor type 1

1

1

High-throughput

0.536

High

867949

GLR
Glucagon receptor

1

3

High-throughput

0.536

High

869589

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.536

High

869610

TLCD5
TLC domain-containing protein 5

1

1

High-throughput

0.536

High

170695

CLGN
Calmegin

2

17

Small-scale

0.521

High

869644

RFT1
Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1

2

2

Small-scale

0.521

High

190550

COPT2
Protein SLC31A2

1

0

High-throughput

0.513

High

869562

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.513

High

869646

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

869663

S26A6
Solute carrier family 26 member 6

1

0

High-throughput

0.513

High

869666

S22A4
Solute carrier family 22 member 4

1

0

High-throughput

0.513

High

126501

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

181277

PGRC2
Membrane-associated progesterone receptor component 2

1

4

Small-scale

0.479

High

189451

STX7
Syntaxin-7

1

15

High-throughput

0.479

High

225954

STX6
Syntaxin-6

1

4

High-throughput

0.479

High

299109

FLOT1
Flotillin-1

1

8

High-throughput

0.479

High

341001

DIRA3
GTP-binding protein Di-Ras3

1

13

High-throughput

0.479

High

350219

FADS2
Acyl-CoA 6-desaturase

1

5

Small-scale

0.479

High

417309

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

High-throughput

0.479

High

418002

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.479

High

463400

LYN
Tyrosine-protein kinase Lyn

1

4

High-throughput

0.479

High

466148

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

540353

LAMP1
Lysosome-associated membrane glycoprotein 1

1

7

High-throughput

0.479

High

561941

LAMP2
Lysosome-associated membrane glycoprotein 2

1

7

High-throughput

0.479

High

580924

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.479

High

582710

EZRI
Ezrin

1

5

High-throughput

0.479

High

596618

NCPR
NADPH--cytochrome P450 reductase

1

4

Small-scale

0.479

High

601210

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

605593

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.479

High

630470

RAB3B
Ras-related protein Rab-3B

1

5

High-throughput

0.479

High

631114

RAB5A
Ras-related protein Rab-5A

1

13

High-throughput

0.479

High

710117

EPHA2
Ephrin type-A receptor 2

1

10

High-throughput

0.479

High

715477

MARCS
Myristoylated alanine-rich C-kinase substrate

1

2

High-throughput

0.479

High

777649

VGFR3
Vascular endothelial growth factor receptor 3

1

8

High-throughput

0.479

High

869563

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.479

High

869564

RAB5C
Ras-related protein Rab-5C

1

13

High-throughput

0.479

High

869565

RAB9A
Ras-related protein Rab-9A

1

9

High-throughput

0.479

High

869566

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

869568

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

869569

AFAD
Afadin

1

18

High-throughput

0.479

High

869571

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

869572

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

869574

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

869575

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

869576

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

869579

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

869581

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

869583

CAV1
Caveolin-1

1

3

High-throughput

0.479

High

869587

CKAP4
Cytoskeleton-associated protein 4

1

4

High-throughput

0.479

High

869588

STX4
Syntaxin-4

1

15

High-throughput

0.479

High

869593

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.479

High

869597

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

869598

OCLN
Occludin

1

1

High-throughput

0.479

High

869604

S27A3
Long-chain fatty acid transport protein 3

1

2

Small-scale

0.479

High

869606

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

2

Small-scale

0.479

High

869607

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

869609

QSOX2
Sulfhydryl oxidase 2

1

8

Small-scale

0.479

High

869612

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

869621

CXD3
Gap junction delta-3 protein

1

4

High-throughput

0.479

High

869638

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

869642

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

869653

RHOV
Rho-related GTP-binding protein RhoV

1

20

High-throughput

0.479

High

869655

PIGS
GPI-anchor transamidase component PIGS

1

2

Small-scale

0.479

High

869656

SEC62
Translocation protein SEC62

1

3

High-throughput

0.479

High

869657

SORT
Sortilin

1

2

Small-scale

0.479

High

869670

DNJC5
DnaJ homolog subfamily C member 5

1

5

High-throughput

0.479

High

869672

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

869673

TMT1A
Thiol S-methyltransferase TMT1A

1

3

High-throughput

0.479

High

869675

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

869687

ELOV5
Very long chain fatty acid elongase 5

1

2

High-throughput

0.479

High

869688

TM216
Transmembrane protein 216

1

3

High-throughput

0.479

High

869689

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

869691

DNJ5B
DnaJ homolog subfamily C member 5B

1

6

High-throughput

0.479

High

869695

LAMP3
Lysosome-associated membrane glycoprotein 3

1

7

High-throughput

0.479

High

869590

S39A6
Zinc transporter ZIP6

1

0

Small-scale

0.458

High

869654

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

869692

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

0

Small-scale

0.458

High

161201

EI24
Etoposide-induced protein 2.4 homolog

1

5

High-throughput

0.445

High

249444

ACSL4
Long-chain-fatty-acid--CoA ligase 4

1

5

High-throughput

0.445

High

261121

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.445

High

338590

AGRL2
Adhesion G protein-coupled receptor L2

1

4

High-throughput

0.445

High

693392

CERS1
Ceramide synthase 1

1

13

High-throughput

0.445

High

813026

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

2

High-throughput

0.445

High

869582

AT2C1
Calcium-transporting ATPase type 2C member 1

1

5

High-throughput

0.445

High

869584

TAP1
Antigen peptide transporter 1

1

7

High-throughput

0.445

High

869585

TAP2
Antigen peptide transporter 2

1

7

High-throughput

0.445

High

869595

DHC24
Delta(24)-sterol reductase

1

4

High-throughput

0.445

High

869605

LPCT4
Lysophospholipid acyltransferase LPCAT4

1

12

High-throughput

0.445

High

869613

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

4

High-throughput

0.445

High

869614

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

10

High-throughput

0.445

High

869622

GHDC
GH3 domain-containing protein

1

2

High-throughput

0.445

High

869623

ABD12
Lysophosphatidylserine lipase ABHD12

1

2

High-throughput

0.445

High

869628

GOGA5
Golgin subfamily A member 5

1

7

High-throughput

0.445

High

869629

PO210
Nuclear pore membrane glycoprotein 210

1

5

High-throughput

0.445

High

869630

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

1

High-throughput

0.445

High

869632

NAT14
Probable N-acetyltransferase 14

1

5

High-throughput

0.445

High

869636

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.445

High

869649

CERS2
Ceramide synthase 2

1

13

High-throughput

0.445

High

869651

S35E1
Solute carrier family 35 member E1

1

1

High-throughput

0.445

High

869652

CLP1L
Lipid scramblase CLPTM1L

1

7

High-throughput

0.445

High

869659

SGMR1
Sigma non-opioid intracellular receptor 1

1

3

High-throughput

0.445

High

869661

NDC1
Nucleoporin NDC1

1

1

High-throughput

0.445

High

869676

GBA2
Non-lysosomal glucosylceramidase

1

1

High-throughput

0.445

High

869678

WDR6
tRNA

1

2

High-throughput

0.445

High

869679

ABCB6
ATP-binding cassette sub-family B member 6

1

5

High-throughput

0.445

High

869680

RTN4
Reticulon-4

1

7

High-throughput

0.445

High

869693

AMFR
E3 ubiquitin-protein ligase AMFR

1

6

High-throughput

0.445

High

139825

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

1

High-throughput

0.437

High

165544

SCAM3
Secretory carrier-associated membrane protein 3

1

3

Small-scale

0.437

High

519076

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

1

High-throughput

0.437

High

630719

RAB4A
Ras-related protein Rab-4A

1

10

High-throughput

0.437

High

869567

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

3

Small-scale

0.437

High

869573

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.437

High

869577

RB11A
Ras-related protein Rab-11A

1

4

High-throughput

0.437

High

869591

OS9
Protein OS-9

1

1

Small-scale

0.437

High

869594

KS6A2
Ribosomal protein S6 kinase alpha-2

1

2

High-throughput

0.437

High

869600

TM41B
Transmembrane protein 41B

1

2

High-throughput

0.437

High

869603

SYEM
Nondiscriminating glutamyl-tRNA synthetase EARS2, mitochondrial

1

1

Small-scale

0.437

High

869611

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

869616

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

869626

DHB11
Estradiol 17-beta-dehydrogenase 11

1

6

High-throughput

0.437

High

869634

SNX19
Sorting nexin-19

1

12

Small-scale

0.437

High

869643

CK052
Uncharacterized protein C11orf52

1

1

High-throughput

0.437

High

869668

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.437

High

354451

PX11B
Peroxisomal membrane protein 11B

1

0

High-throughput

0.426

High

869618

ANKL2
Ankyrin repeat and LEM domain-containing protein 2

1

0

High-throughput

0.426

High

869624

PNKD
Probable thioesterase PNKD

1

0

High-throughput

0.426

High

869625

GOLM1
Golgi membrane protein 1

1

0

High-throughput

0.426

High

869635

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.426

High

869639

SEM4D
Semaphorin-4D

1

0

High-throughput

0.426

High

869641

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

869669

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.426

High

869684

CLN6
Ceroid-lipofuscinosis neuronal protein 6

1

0

High-throughput

0.426

High

869690

PKHB1
Pleckstrin homology domain-containing family B member 1

1

0

High-throughput

0.426

High

869697

T184B
Transmembrane protein 184B

1

0

High-throughput

0.426

High

268993

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

5

High-throughput

0.407

High

869592

OXA1L
Mitochondrial inner membrane protein OXA1L

1

1

High-throughput

0.407

High

869599

GPAT3
Glycerol-3-phosphate acyltransferase 3

1

10

High-throughput

0.407

High

869602

RABL3
Rab-like protein 3

1

13

High-throughput

0.407

High

869620

CP4X1
Cytochrome P450 4X1

1

2

High-throughput

0.407

High

869631

THEM6
Protein THEM6

1

4

High-throughput

0.407

High

869637

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

1

High-throughput

0.407

High

869645

ERLEC
Endoplasmic reticulum lectin 1

1

1

High-throughput

0.407

High

869647

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

2

High-throughput

0.407

High

869660

PGAP4
GPI-N-acetylgalactosamine transferase PGAP4

1

2

High-throughput

0.407

High

869674

RN121
E3 ubiquitin ligase RNF121

1

2

High-throughput

0.407

High

869681

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

13

High-throughput

0.407

High

869696

TMX2
Thioredoxin-related transmembrane protein 2

1

1

High-throughput

0.407

High

869698

SNX13
Sorting nexin-13

1

12

High-throughput

0.407

High

869601

MKS3
Meckelin

1

0

High-throughput

0.249

Low

869608

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

869617

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

869667

UN93B
Protein unc-93 homolog B1

1

0

Small-scale

0.249

Low

869683

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

869694

EPDR1
Mammalian ependymin-related protein 1

1

0

Small-scale

0.249

Low

139094

FAAH1
Fatty-acid amide hydrolase 1

1

0

High-throughput

0.232

Low

450224

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.232

Low

869619

GLBL2
Beta-galactosidase-1-like protein 2

1

0

High-throughput

0.232

Low

869648

C1GLC
C1GALT1-specific chaperone 1

1

0

High-throughput

0.232

Low

869650

BSCL2
Seipin

1

0

High-throughput

0.232

Low

869701

PXMP4
Peroxisomal membrane protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025