HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ANXA2 (P07355)
Annexin A2 (Annexin II) (Annexin-2) (Calpactin I heavy chain) (Calpactin-1 heavy chain) (Chromobindin-8) (Lipocortin II) (Placental anticoagulant protein IV) (PAP-IV) (Protein I) (p36)
Gene: ANXA2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35987950, 35256949, 24244333
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	4

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 339
+	Hs
		226894 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANX11_HUMAN (15-339): 2.17e-178: 505: 46.46
+	Hs
		226226 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANXA1_HUMAN (1-338): 4.33e-159: 450: 50.72
+	Hs
		226384 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANXA3_HUMAN (22-339): 1.34e-158: 448: 47.80
+	Hs
		226500 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ANXA7_HUMAN (191-338): 7.11e-30: 120: 28.19