HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: KAP2 (P13861)
cAMP-dependent protein kinase type II-alpha regulatory subunit
Gene: PRKAR2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 404
+	Hs
		226346 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KAP0_HUMAN (210-396): 6.96e-18: 86.4: 22.46
+	Hs
		228214 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RPGF4_HUMAN (105-260): 1.03e-11: 69: 22.09
+	Hs
		228001 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PLPL6_HUMAN (86-284): 1.4e-10: 65.6: 9.91
+	Hs
		1172936 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		PLPL7_HUMAN (34-395): 1.65e-56: 202: 18.58
+	Sc
		477444 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		NTE1_YEAST (62-402): 6.38e-48: 177: 16.44
+	Hs
		475273 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KAP0_HUMAN (210-396): 6.96e-18: 86.4: 22.46
+	At
		1091636 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AKT2_ARATH (244-403): 4.95e-18: 88.3: 18.75
+	Hs
		475386 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KAP1_HUMAN (215-396): 4.15e-17: 84: 22.53
+	Hs
		476030 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PLPL6_HUMAN (86-284): 1.4e-10: 65.6: 9.91