Protein: 5HT2C
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)

Gene: 5HT2C, HTR2C
Organism: Homo sapiens
Interactions: 163
UniProt ID: P28335

Gene Ontology (top 5):
GO:0001587 - Gq/11-coupled serotonin receptor activity
GO:0001662 - behavioral fear response
GO:0004993 - G protein-coupled serotonin receptor activity
GO:0005886 - plasma membrane
GO:0006874 - intracellular calcium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

702744

5HT2C
5-hydroxytryptamine receptor 2C

3

15

Small-scale

0.827

High

702773

MTR1L
Melatonin-related receptor

2

18

High-throughput

0.811

High

701444

5HT2A
5-hydroxytryptamine receptor 2A

2

16

Small-scale

0.743

High

186885

GPR37
Prosaposin receptor GPR37

1

18

High-throughput

0.698

High

702852

RTN4
Reticulon-4

3

5

High-throughput

0.678

High

299739

MPDZ
Multiple PDZ domain protein

3

20

Small-scale

0.672

High

702840

TM147
BOS complex subunit TMEM147

4

0

High-throughput

0.669

High

702745

HMOX2
Heme oxygenase 2

3

1

High-throughput

0.662

High

702860

S39A1
Zinc transporter ZIP1

2

9

High-throughput

0.633

High

255986

S19A2
Thiamine transporter 1

2

1

High-throughput

0.628

High

443672

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

5

High-throughput

0.628

High

702757

ACTA
Actin, aortic smooth muscle

2

5

High-throughput

0.628

High

702760

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

10

High-throughput

0.628

High

702762

CAV1
Caveolin-1

2

4

High-throughput

0.628

High

702788

LMBD2
G-protein coupled receptor-associated protein LMBRD2

2

3

High-throughput

0.628

High

702803

LRC8A
Volume-regulated anion channel subunit LRRC8A

2

5

High-throughput

0.628

High

702813

S35G2
Solute carrier family 35 member G2

2

3

High-throughput

0.628

High

702851

GPC5C
G-protein coupled receptor family C group 5 member C

2

8

High-throughput

0.628

High

702854

SERC1
Serine incorporator 1

2

3

High-throughput

0.628

High

702857

LIN7C
Protein lin-7 homolog C

2

20

Small-scale

0.619

High

702817

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.618

High

466869

ACM4
Muscarinic acetylcholine receptor M4

1

19

Small-scale

0.618

High

702748

5HT2B
5-hydroxytryptamine receptor 2B

1

15

Small-scale

0.618

High

702749

MTR1A
Melatonin receptor type 1A

1

15

Small-scale

0.618

High

702751

MTR1B
Melatonin receptor type 1B

1

16

Small-scale

0.618

High

702754

BI1
Bax inhibitor 1

2

4

High-throughput

0.606

High

702856

S39A9
Zinc transporter ZIP9

2

9

High-throughput

0.606

High

273165

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

7

High-throughput

0.604

High

334690

IPO7
Importin-7

3

9

High-throughput

0.604

High

350527

CF047
Uncharacterized protein C6orf47

3

2

High-throughput

0.604

High

702794

CERS6
Ceramide synthase 6

3

13

High-throughput

0.604

High

702801

RETR3
Reticulophagy regulator 3

3

3

High-throughput

0.604

High

702805

CERS5
Ceramide synthase 5

3

13

High-throughput

0.604

High

702807

ARL10
ADP-ribosylation factor-like protein 10

3

9

High-throughput

0.604

High

702809

RETR2
Reticulophagy regulator 2

3

3

High-throughput

0.604

High

702825

CERS2
Ceramide synthase 2

3

13

High-throughput

0.604

High

702863

SEC63
Translocation protein SEC63 homolog

3

1

High-throughput

0.604

High

609586

LEG3
Galectin-3

2

0

High-throughput

0.602

High

702752

KNTC1
Kinetochore-associated protein 1

2

0

High-throughput

0.602

High

702789

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

2

0

High-throughput

0.602

High

702815

CIP2A
Protein CIP2A

2

0

High-throughput

0.602

High

702770

S39A6
Zinc transporter ZIP6

2

9

High-throughput

0.601

High

702753

EMP1
Epithelial membrane protein 1

2

0

High-throughput

0.580

High

702774

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

0

High-throughput

0.578

High

62097

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

2

High-throughput

0.574

High

173661

BTAF1
TATA-binding protein-associated factor 172

2

1

High-throughput

0.574

High

193680

TPSN
Tapasin

2

1

High-throughput

0.574

High

248562

FADS1
Acyl-CoA

2

1

High-throughput

0.574

High

665524

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

1

High-throughput

0.574

High

702772

MTX1
Metaxin-1

2

1

High-throughput

0.574

High

702782

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

2

1

High-throughput

0.574

High

702784

S35F1
Solute carrier family 35 member F1

2

1

High-throughput

0.574

High

702786

ECM29
Proteasome adapter and scaffold protein ECM29

2

7

High-throughput

0.574

High

702790

RINT1
RAD50-interacting protein 1

2

1

High-throughput

0.574

High

702791

MBOA5
Lysophospholipid acyltransferase 5

2

3

High-throughput

0.574

High

702795

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

1

High-throughput

0.574

High

702799

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

2

1

High-throughput

0.574

High

702804

S35F2
Solute carrier family 35 member F2

2

1

High-throughput

0.574

High

702812

GOGA5
Golgin subfamily A member 5

2

3

High-throughput

0.574

High

702824

TV23C
Golgi apparatus membrane protein TVP23 homolog C

2

2

High-throughput

0.574

High

702831

RBM14
RNA-binding protein 14

2

1

High-throughput

0.574

High

702849

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

2

High-throughput

0.574

High

702850

TM9S3
Transmembrane 9 superfamily member 3

2

3

High-throughput

0.574

High

702855

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

2

High-throughput

0.574

High

702858

RMND1
Required for meiotic nuclear division protein 1 homolog

2

1

High-throughput

0.574

High

702864

IPO11
Importin-11

2

8

High-throughput

0.574

High

702865

XPO7
Exportin-7

2

7

High-throughput

0.574

High

702869

ANGE1
Protein angel homolog 1

2

1

High-throughput

0.574

High

702873

TNPO3
Transportin-3

2

9

High-throughput

0.574

High

164533

TNPO2
Transportin-2

2

7

High-throughput

0.558

High

336153

CNIH1
Protein cornichon homolog 1

2

1

High-throughput

0.553

High

702837

LRRC1
Leucine-rich repeat-containing protein 1

2

2

High-throughput

0.549

High

292561

RENR
Renin receptor

1

1

High-throughput

0.541

High

603845

CXA1
Gap junction alpha-1 protein

1

3

High-throughput

0.541

High

692179

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

2

High-throughput

0.541

High

702779

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.541

High

702780

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

10

High-throughput

0.541

High

702833

TM9S2
Transmembrane 9 superfamily member 2

1

3

High-throughput

0.541

High

702861

GPC5B
G-protein coupled receptor family C group 5 member B

1

8

High-throughput

0.541

High

230758

EXTL3
Exostosin-like 3

1

2

High-throughput

0.536

High

702758

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.536

High

702868

S39AA
Zinc transporter ZIP10

1

9

High-throughput

0.536

High

506557

GPHRB
Golgi pH regulator B

2

3

High-throughput

0.533

High

702769

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.527

High

702756

MYPR
Myelin proteolipid protein

1

0

High-throughput

0.518

High

702834

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.518

High

702785

DCAF8
DDB1- and CUL4-associated factor 8

1

1

High-throughput

0.514

High

702766

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

702771

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

High-throughput

0.513

High

702775

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.513

High

702820

CDS1
Phosphatidate cytidylyltransferase 1

1

0

High-throughput

0.513

High

85338

GPHRA
Golgi pH regulator A

2

3

High-throughput

0.504

High

702759

DLG4
Disks large homolog 4

1

18

Small-scale

0.501

High

702761

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

20

Small-scale

0.501

High

702767

DLG1
Disks large homolog 1

1

16

High-throughput

0.501

High

702776

SCRIB
Protein scribble homolog

1

20

High-throughput

0.501

High

702826

CREL1
Protein disulfide isomerase CRELD1

1

4

High-throughput

0.494

High

702828

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.494

High

702845

GHITM
Growth hormone-inducible transmembrane protein

1

4

High-throughput

0.494

High

226405

SNG2
Synaptogyrin-2

1

3

High-throughput

0.489

High

397785

ATP8
ATP synthase F(0) complex subunit 8

1

1

High-throughput

0.489

High

536237

PPAL
Lysosomal acid phosphatase

1

1

High-throughput

0.489

High

702793

BRAT1
Integrator complex assembly factor BRAT1

1

1

High-throughput

0.489

High

702800

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

11

High-throughput

0.489

High

702811

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.489

High

702816

SFXN5
Sideroflexin-5

1

1

High-throughput

0.489

High

702822

F241B
Protein FAM241B

1

1

High-throughput

0.489

High

702829

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

3

High-throughput

0.489

High

702830

IPO9
Importin-9

1

9

High-throughput

0.489

High

702835

CND3
Condensin complex subunit 3

1

1

High-throughput

0.489

High

702853

EI2BG
Translation initiation factor eIF2B subunit gamma

1

3

High-throughput

0.489

High

190588

MRP4
ATP-binding cassette sub-family C member 4

1

2

High-throughput

0.445

High

239739

PCDH7
Protocadherin-7

1

2

High-throughput

0.445

High

702746

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.445

High

702747

SDC4
Syndecan-4

1

1

High-throughput

0.445

High

702750

AGRE5
Adhesion G protein-coupled receptor E5

1

7

High-throughput

0.445

High

702778

MSMO1
Methylsterol monooxygenase 1

1

2

High-throughput

0.445

High

702808

TM87A
Transmembrane protein 87A

1

2

High-throughput

0.445

High

702846

GOLP3
Golgi phosphoprotein 3

1

1

High-throughput

0.445

High

702847

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

2

High-throughput

0.445

High

702848

CELR2
Cadherin EGF LAG seven-pass G-type receptor 2

1

1

High-throughput

0.445

High

702866

LCAP
Leucyl-cystinyl aminopeptidase

1

3

High-throughput

0.445

High

702810

DGLB
Diacylglycerol lipase-beta

1

0

High-throughput

0.426

High

168195

HAT1
Histone acetyltransferase type B catalytic subunit

1

1

High-throughput

0.407

High

323965

CSTN1
Calsyntenin-1

1

3

High-throughput

0.407

High

351078

ECD
Protein ecdysoneless homolog

1

1

High-throughput

0.407

High

702763

KDSR
3-ketodihydrosphingosine reductase

1

5

High-throughput

0.407

High

702765

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

1

High-throughput

0.407

High

702781

Q4LE60
TNPO2 variant protein

1

7

High-throughput

0.407

High

702783

RABL3
Rab-like protein 3

1

1

High-throughput

0.407

High

702819

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

2

High-throughput

0.407

High

702823

TRI44
Tripartite motif-containing protein 44

1

2

High-throughput

0.407

High

702832

CLCC1
Chloride channel CLIC-like protein 1

1

1

High-throughput

0.407

High

702836

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

1

High-throughput

0.407

High

702838

PTSS2
Phosphatidylserine synthase 2

1

2

High-throughput

0.407

High

702859

T161A
Transmembrane protein 161A

1

1

High-throughput

0.407

High

702870

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.407

High

702871

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

1

High-throughput

0.407

High

702798

HEAT3
HEAT repeat-containing protein 3

3

0

High-throughput

0.345

High

702814

TBC15
TBC1 domain family member 15

3

0

High-throughput

0.345

High

702872

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

3

0

High-throughput

0.345

High

702792

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

0

High-throughput

0.328

High

702796

D19L4
Probable C-mannosyltransferase DPY19L4

2

0

High-throughput

0.328

High

702806

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

0

High-throughput

0.328

High

702821

GLMN
Glomulin

2

0

High-throughput

0.328

High

702827

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.328

High

702843

5NT3A
Cytosolic 5'-nucleotidase 3A

2

0

High-throughput

0.328

High

702755

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.282

High

702764

TMM94
Transmembrane protein 94

1

0

High-throughput

0.282

High

702768

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.282

High

702818

SRALN
Sarcoplasmic/endoplasmic reticulum calcium ATPase regulator ARLN

1

0

High-throughput

0.282

High

702844

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.282

High

702867

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

187011

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.279

Low

702777

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

702797

TRM11
tRNA

1

0

High-throughput

0.279

Low

702839

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.279

Low

702841

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.279

Low

702842

DERL2
Derlin-2

1

0

High-throughput

0.279

Low

702862

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low

702787

SE1L3
Protein sel-1 homolog 3

1

0

High-throughput

0.232

Low

702802

TEX2
Testis-expressed protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025