HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: IF4B (P23588)
Eukaryotic translation initiation factor 4B (eIF-4B)
Gene: EIF4B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.76	0.60	0.678

Property	Details
Experiments	35191952, 35105670, 24244333
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 611
+	Hs
		227414 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CIRBP_HUMAN (98-257): 1.65e-29: 116: 24.85
+	Hs
		226375 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		227642 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PAP1L_HUMAN (49-389): 3.99e-23: 105: 10.28
+	Hs
		228678 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP3_HUMAN (54-547): 1.45e-22: 104: 11.07
+	Hs
		227354 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72
+	Hs
		228332 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DAZP1_HUMAN (97-186): 2.18e-21: 98.8: 17.78
+	Hs
		1031383 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72
+	Hs
		312602 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		CIRBP_HUMAN (98-257): 1.65e-29: 116: 24.85
+	Hs
		312462 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Hs
		312642 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		DAZP1_HUMAN (97-186): 2.18e-21: 98.8: 17.78
+	Zm
		20418 Q42415_MAIZE (1-153): 8.84e-50: 179: 20.13		A0A1D6HKR9_MAIZE (87-372): 7.49e-34: 133: 15.07
+	At
		186465 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP4_ARATH (96-555): 3.13e-37: 148: 13.25
+	At
		981214 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CP31A_ARATH (27-179): 8.89e-32: 127: 23.27
+	Hs
		475739 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		CIRBP_HUMAN (98-257): 1.65e-29: 116: 24.85
+	Hs
		475288 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP1_HUMAN (49-537): 3.4e-25: 112: 10.22
+	Zm
		18719 C0P3C8_MAIZE (227-459): 4.54e-25: 106: 17.87		A0A1D6H7I7_MAIZE (96-391): 1.24e-31: 127: 17.51
+	Hs
		475708 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PABP4_HUMAN (49-389): 1.92e-21: 100: 9.72
+	Hs
		475631 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBM3_HUMAN (98-241): 2.31e-22: 95.7: 24.83
+	At
		983451 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PABP5_ARATH (49-390): 2.03e-18: 91.2: 13.03