HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PSA1 (P25786)
Proteasome subunit alpha type-1 (30 kDa prosomal protein) (PROS-30) (Macropain subunit C2) (Multicatalytic endopeptidase complex subunit C2) (Proteasome component C2) (Proteasome nu chain)
Gene: PSMA1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	12150907, 35256949, 23503661, 32814053
Identification Methods	pull down, affinity chromatography technology, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 465 Hs			1 263
+	Hs
		156176 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19
+	Hs
		228119 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSMA8_HUMAN (4-234): 1.7e-93: 277: 32.08
+	Hs
		226590 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81
+	Hs
		227023 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Hs
		226567 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Hs
		637475 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Hs
		637539 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Hs
		893742 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	Hs
		474931 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		PSA4_HUMAN (1-233): 4.82e-91: 271: 28.75
+	Hs
		475358 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA1_HUMAN (1-263): 3.26e-109: 317: 100.00
+	Hs
		156205 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA7_HUMAN (6-234): 9.99e-96: 282: 33.19
+	At
		189234 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA7B_ARATH (4-233): 4.98e-96: 283: 32.34
+	At
		188704 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA1B_ARATH (1-240): 1.35e-94: 280: 50.00
+	At
		709289 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA1A_ARATH (1-238): 1.05e-93: 278: 50.00
+	Hs
		475369 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA5_HUMAN (1-236): 5.66e-93: 275: 28.81
+	At
		188696 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA2A_ARATH (1-237): 1.71e-93: 276: 32.64
+	Hs
		475547 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PSA6_HUMAN (1-240): 1.64e-92: 274: 25.00
+	At
		286456 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA4A_ARATH (1-245): 1.92e-91: 272: 28.85
+	At
		286449 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA6A_ARATH (1-240): 4.34e-91: 270: 29.03
+	At
		672527 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		PSA7A_ARATH (5-218): 8.98e-37: 132: 35.32