HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RFC5 (P40937)
Replication factor C subunit 5 (Activator 1 36 kDa subunit) (A1 36 kDa subunit) (Activator 1 subunit 5) (Replication factor C 36 kDa subunit) (RF-C 36 kDa subunit) (RFC36)
Gene: RFC5

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0019899 - enzyme binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 340
+	Hs
		226670 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC4_HUMAN (1-331): 9.47e-89: 272: 36.77
+	Hs
		226671 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35
+	Hs
		226740 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RFC3_HUMAN (21-340): 6.47e-62: 202: 24.00
+	Hs
		226044 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		VPS4B_HUMAN (2-315): 1e-55: 189: 11.18
+	Hs
		475441 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC5_HUMAN (1-340): 5.53e-102: 305: 100.00
+	Hs
		475409 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC2_HUMAN (2-331): 2.97e-86: 265: 35.35
+	Hs
		475442 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RFC3_HUMAN (21-340): 6.47e-62: 202: 24.00
+	At
		1092019 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		FTSH5_ARATH (29-339): 2.03e-55: 193: 15.86