HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RGS2 (P41220)
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
Gene: RGS2

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.60	0.672

Property	Details
Experiments	16169070, 21900206, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 211
+	Hs
		663 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		A0A087WUY2_HUMAN (37-206): 4.21e-68: 208: 48.82
+	Hs
		226088 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RGS9_HUMAN (52-211): 3.08e-57: 193: 32.12
+	Hs
		158578 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RGS13_HUMAN (54-207): 1.03e-56: 178: 42.21
+	Hs
		475447 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RGS2_HUMAN (1-211): 4.66e-76: 229: 100.00
+	Hs
		170594 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AXIN1_HUMAN (9-205): 3.02e-53: 184: 26.47