Protein: PPP5
Serine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)

Gene: PPP5, PPP5C
Organism: Homo sapiens
Interactions: 170
UniProt ID: P53041

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0000278 - mitotic cell cycle
GO:0001965 - G-protein alpha-subunit binding
GO:0003723 - RNA binding
GO:0004721 - phosphoprotein phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

461300

HS90A
Heat shock protein HSP 90-alpha

14

12

Small-scale

0.985

High

468210

HS90B
Heat shock protein HSP 90-beta

7

13

Small-scale

0.972

High

731115

STIP1
Stress-induced-phosphoprotein 1

2

10

Small-scale

0.820

High

916668

RAB41
Ras-related protein Rab-41

2

1

High-throughput

0.811

High

916659

TEBP
Prostaglandin E synthase 3

5

3

Small-scale

0.722

High

916663

CDC37
Hsp90 co-chaperone Cdc37

4

2

Small-scale

0.702

High

529399

TAU
Microtubule-associated protein tau

4

20

Small-scale

0.694

High

247268

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

19

High-throughput

0.691

High

916631

LIMK2
LIM domain kinase 2

1

1

High-throughput

0.691

High

916649

FLII
Protein flightless-1 homolog

1

20

High-throughput

0.691

High

916702

LRRC1
Leucine-rich repeat-containing protein 1

1

20

High-throughput

0.691

High

916727

SGT1
Protein SGT1 homolog

1

12

High-throughput

0.691

High

717731

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

20

Small-scale

0.665

High

185549

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

11

High-throughput

0.647

High

718525

CDC27
Cell division cycle protein 27 homolog

1

7

Small-scale

0.647

High

916630

PPP5
Serine/threonine-protein phosphatase 5

1

15

Small-scale

0.646

High

160451

IRS4
Insulin receptor substrate 4

2

3

High-throughput

0.635

High

916720

CHRD1
Cysteine and histidine-rich domain-containing protein 1

2

3

High-throughput

0.633

High

411635

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.618

High

916638

ACTB
Actin, cytoplasmic 1

1

15

Small-scale

0.618

High

916644

ACTG
Actin, cytoplasmic 2

1

15

Small-scale

0.618

High

916646

P2R3A
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha

1

7

Small-scale

0.618

High

916653

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.618

High

916665

CRY2
Cryptochrome-2

2

7

Small-scale

0.614

High

916722

AGO1
Protein argonaute-1

2

5

High-throughput

0.612

High

363018

EGFR
Epidermal growth factor receptor

2

14

Small-scale

0.608

High

878250

DPOD2
DNA polymerase delta subunit 2

2

0

High-throughput

0.602

High

395743

ESR1
Estrogen receptor

1

20

Small-scale

0.594

High

916710

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.590

High

241172

PRKN
E3 ubiquitin-protein ligase parkin

2

15

High-throughput

0.584

High

117618

K9JA46
Epididymis luminal secretory protein 52

1

12

High-throughput

0.575

High

916666

H90B4
Putative heat shock protein HSP 90-beta 4

1

13

High-throughput

0.575

High

916667

HS905
Putative heat shock protein HSP 90-alpha A5

1

14

High-throughput

0.575

High

897671

CDK9
Cyclin-dependent kinase 9

1

20

High-throughput

0.565

High

822547

VHL
von Hippel-Lindau disease tumor suppressor

1

1

Small-scale

0.561

High

877070

KC1D
Casein kinase I isoform delta

1

13

Small-scale

0.561

High

916645

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

3

Small-scale

0.561

High

916681

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

7

Small-scale

0.561

High

916701

M3K5
Mitogen-activated protein kinase kinase kinase 5

1

20

Small-scale

0.561

High

697479

PYR1
Multifunctional protein CAD

1

7

High-throughput

0.554

High

916669

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

1

High-throughput

0.554

High

916706

AGO3
Protein argonaute-3

1

5

High-throughput

0.554

High

916725

NUDC
Nuclear migration protein nudC

1

4

High-throughput

0.554

High

916648

TP53B
TP53-binding protein 1

1

10

Small-scale

0.552

High

916695

ESR2
Estrogen receptor beta

1

20

Small-scale

0.552

High

916633

XPO2
Exportin-2

1

7

High-throughput

0.541

High

916657

SIM2
Single-minded homolog 2

1

8

High-throughput

0.541

High

916712

BRWD1
Bromodomain and WD repeat-containing protein 1

1

9

High-throughput

0.541

High

289474

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

10

High-throughput

0.536

High

336902

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

1

High-throughput

0.536

High

342137

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.536

High

346919

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

536809

HSP7C
Heat shock cognate 71 kDa protein

1

14

Small-scale

0.536

High

600777

HSP76
Heat shock 70 kDa protein 6

1

16

High-throughput

0.536

High

650535

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

15

High-throughput

0.536

High

658582

KS6B1
Ribosomal protein S6 kinase beta-1

1

14

High-throughput

0.536

High

690850

1433T
14-3-3 protein theta

1

15

High-throughput

0.536

High

699660

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

4

High-throughput

0.536

High

729697

1433B
14-3-3 protein beta/alpha

1

15

High-throughput

0.536

High

846730

GRK6
G protein-coupled receptor kinase 6

1

16

High-throughput

0.536

High

866456

PA24A
Cytosolic phospholipase A2

1

2

High-throughput

0.536

High

899309

TCPD
T-complex protein 1 subunit delta

1

18

Small-scale

0.536

High

905527

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

916641

GRB2
Growth factor receptor-bound protein 2

1

10

High-throughput

0.536

High

916643

RACK1
Small ribosomal subunit protein RACK1

1

8

High-throughput

0.536

High

916647

CDK18
Cyclin-dependent kinase 18

1

14

High-throughput

0.536

High

916652

ILK
Scaffold protein ILK

1

5

High-throughput

0.536

High

916656

CDK13
Cyclin-dependent kinase 13

1

18

High-throughput

0.536

High

916660

RBBP5
Retinoblastoma-binding protein 5

1

5

High-throughput

0.536

High

916662

DDB1
DNA damage-binding protein 1

1

5

High-throughput

0.536

High

916664

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

8

High-throughput

0.536

High

916671

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.536

High

916672

KSR2
Kinase suppressor of Ras 2

1

20

High-throughput

0.536

High

916674

GADL1
Acidic amino acid decarboxylase GADL1

1

3

High-throughput

0.536

High

916676

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

5

High-throughput

0.536

High

916677

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

4

High-throughput

0.536

High

916678

CD37L
Hsp90 co-chaperone Cdc37-like 1

1

1

High-throughput

0.536

High

916691

MK15
Mitogen-activated protein kinase 15

1

11

High-throughput

0.536

High

916699

TSSK2
Testis-specific serine/threonine-protein kinase 2

1

15

High-throughput

0.536

High

916700

PSKH2
Serine/threonine-protein kinase H2

1

19

High-throughput

0.536

High

916709

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

15

High-throughput

0.536

High

916711

LATS2
Serine/threonine-protein kinase LATS2

1

16

High-throughput

0.536

High

916714

CNTLN
Centlein

1

15

High-throughput

0.536

High

916723

INTU
Protein inturned

1

1

High-throughput

0.536

High

916729

MRCKB
Serine/threonine-protein kinase MRCK beta

1

8

High-throughput

0.536

High

327573

ELP1
Elongator complex protein 1

1

0

High-throughput

0.513

High

916707

ELP3
Elongator complex protein 3

1

0

High-throughput

0.513

High

916718

ABCF2
ATP-binding cassette sub-family F member 2

1

0

High-throughput

0.513

High

213872

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

9

High-throughput

0.508

High

421766

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.501

High

916658

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

3

Small-scale

0.501

High

916686

CDK20
Cyclin-dependent kinase 20

1

11

Small-scale

0.501

High

885730

KC1E
Casein kinase I isoform epsilon

1

20

Small-scale

0.500

High

916661

CRY1
Cryptochrome-1

1

7

Small-scale

0.500

High

916673

DEFI8
Differentially expressed in FDCP 8 homolog

1

3

High-throughput

0.489

High

916689

FA83F
Protein FAM83F

1

1

High-throughput

0.489

High

916708

FSCN3
Fascin-3

1

1

High-throughput

0.489

High

916716

HACD3
Very-long-chain

1

3

High-throughput

0.489

High

298330

DNJC8
DnaJ homolog subfamily C member 8

1

2

High-throughput

0.479

High

315318

RECQ4
ATP-dependent DNA helicase Q4

1

12

High-throughput

0.479

High

403933

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

442904

PRGR
Progesterone receptor

1

20

Small-scale

0.479

High

467777

MCR
Mineralocorticoid receptor

1

20

Small-scale

0.479

High

473875

NFIC
Nuclear factor 1 C-type

1

6

High-throughput

0.479

High

474568

VIME
Vimentin

1

5

Small-scale

0.479

High

519869

ANDR
Androgen receptor

1

20

Small-scale

0.479

High

588278

RFA2
Replication protein A 32 kDa subunit

1

6

High-throughput

0.479

High

606483

CEBPB
CCAAT/enhancer-binding protein beta

1

7

High-throughput

0.479

High

695005

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

761598

HSP74
Heat shock 70 kDa protein 4

1

20

Small-scale

0.479

High

767769

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

772693

MYH9
Myosin-9

1

12

High-throughput

0.479

High

773136

MYH10
Myosin-10

1

12

High-throughput

0.479

High

776789

MYH11
Myosin-11

1

12

High-throughput

0.479

High

890716

PSN2
Presenilin-2

1

1

High-throughput

0.479

High

916634

TPTE
Putative tyrosine-protein phosphatase TPTE

1

10

High-throughput

0.479

High

916636

DJB13
DnaJ homolog subfamily B member 13

1

6

High-throughput

0.479

High

916637

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

10

High-throughput

0.479

High

916639

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

916640

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

7

High-throughput

0.479

High

916642

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

Small-scale

0.479

High

916650

DUS8
Dual specificity protein phosphatase 8

1

9

High-throughput

0.479

High

916654

BIRC3
Baculoviral IAP repeat-containing protein 3

1

5

High-throughput

0.479

High

916655

ATR
Serine/threonine-protein kinase ATR

1

13

Small-scale

0.479

High

916680

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

16

High-throughput

0.479

High

916684

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

916688

WDTC1
WD and tetratricopeptide repeats protein 1

1

7

High-throughput

0.479

High

916693

TOPB1
DNA topoisomerase 2-binding protein 1

1

11

High-throughput

0.479

High

916694

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

916696

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

916697

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

1

20

High-throughput

0.479

High

916703

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.479

High

916704

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

916705

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

916713

DJC11
DnaJ homolog subfamily C member 11

1

8

High-throughput

0.479

High

916715

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

916719

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

168831

PLD2
Phospholipase D2

1

0

High-throughput

0.458

High

332745

EPM2A
Laforin

1

0

High-throughput

0.458

High

880494

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

916679

DET1
DET1 homolog

1

0

High-throughput

0.458

High

916690

FLCN
Folliculin

1

0

Small-scale

0.458

High

916698

FBXW5
F-box/WD repeat-containing protein 5

1

0

High-throughput

0.458

High

916724

MTMR7
Phosphatidylinositol-3-phosphate phosphatase MTMR7

1

0

High-throughput

0.458

High

701448

5HT2A
5-hydroxytryptamine receptor 2A

1

1

Small-scale

0.457

High

142313

PEX7
Peroxisomal targeting signal 2 receptor

1

10

High-throughput

0.445

High

330088

VENTX
Homeobox protein VENTX

1

6

High-throughput

0.445

High

334161

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

3

High-throughput

0.445

High

628614

CAP7
Azurocidin

1

1

High-throughput

0.445

High

689812

CD27
CD27 antigen

1

1

High-throughput

0.445

High

916632

S12A3
Solute carrier family 12 member 3

1

1

High-throughput

0.445

High

916635

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

916670

A16L1
Autophagy-related protein 16-1

1

18

High-throughput

0.445

High

916682

Q86SX1
Full-length cDNA 5-PRIME end of clone CS0DN005YI08 of Adult brain of Homo sapiens

1

11

High-throughput

0.445

High

916685

ULK2
Serine/threonine-protein kinase ULK2

1

20

High-throughput

0.445

High

916692

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

17

High-throughput

0.445

High

916728

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

13

High-throughput

0.445

High

533626

CLUS
Clusterin

1

0

High-throughput

0.438

High

105623

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

916675

TRI67
Tripartite motif-containing protein 67

1

16

High-throughput

0.437

High

916687

FBXL6
F-box/LRR-repeat protein 6

1

9

High-throughput

0.437

High

916717

KANL3
KAT8 regulatory NSL complex subunit 3

1

0

High-throughput

0.426

High

916721

APC5
Anaphase-promoting complex subunit 5

1

0

High-throughput

0.426

High

916726

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.426

High

886667

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

High-throughput

0.408

High

95785

E5RHT1
Presenilin 2

1

1

High-throughput

0.407

High

116344

H3BSK8
RB binding protein 6, ubiquitin ligase

1

2

High-throughput

0.407

High

916683

BPHL
Serine hydrolase BPHL

2

0

High-throughput

0.318

High

916651

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025