HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HSP13 (P48723)
Heat shock 70 kDa protein 13 (Heat shock protein family A member 13) (Microsomal stress-70 protein ATPase core) (Stress-70 protein chaperone microsome-associated 60 kDa protein)
Gene: HSPA13

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0031072 - heat shock protein binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 471
+	Hs
		226452 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP76_HUMAN (26-470): 0: 585: 36.89
+	Hs
		226353 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP7C_HUMAN (28-469): 0: 584: 36.91
+	Hs
		226663 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HS71L_HUMAN (26-470): 0: 580: 37.56
+	Hs
		226336 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HS71A_HUMAN (28-470): 0: 578: 37.50
+	Hs
		226968 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		HSP72_HUMAN (29-469): 0: 574: 37.28
+	Mm
		1143065 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		HS71A_MOUSE (28-470): 0: 575: 37.05
+	Hs
		312461 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HSP7C_HUMAN (28-469): 0: 584: 36.91
+	Hs
		312496 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		HS71L_HUMAN (26-470): 0: 580: 37.56
+	Hs
		474905 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		HSP7C_HUMAN (28-469): 0: 584: 36.91
+	Hs
		475281 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		HSP7C_HUMAN (28-469): 0: 584: 36.91
+	Sc
		477080 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP71_YEAST (32-449): 2.79e-87: 281: 39.57
+	Sc
		449868 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP73_YEAST (32-449): 3.06e-86: 279: 39.48
+	Sc
		477130 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP74_YEAST (32-449): 2.11e-86: 279: 40.19
+	Sc
		477081 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		HSP72_YEAST (32-449): 2.82e-86: 278: 39.34
+	At
		1092279 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		HSP7E_ARATH (30-458): 1.09e-87: 282: 39.82