HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: NEK2 (P51955)
Serine/threonine-protein kinase Nek2 (EC 2.7.11.1) (HSPK 21) (Never in mitosis A-related kinase 2) (NimA-related protein kinase 2) (NimA-like protein kinase 1)
Gene: NEK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.52	1.00	0.724

Property	Details
Experiments	26387737
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 445
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (2-425): 7.56e-123: 377: 23.56
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (6-391): 5.26e-110: 335: 23.01
+	Hs
		227330 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AAPK1_HUMAN (4-383): 1.46e-108: 333: 27.32
+	Hs
		227317 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	Hs
		227797 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK5_HUMAN (6-275): 1.19e-54: 195: 40.59
+	Hs
		228141 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK9_HUMAN (5-302): 3.01e-52: 190: 36.84
+	Hs
		228149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK7_HUMAN (7-267): 1.49e-47: 167: 35.85
+	Hs
		475012 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STK4_HUMAN (6-442): 1.98e-108: 330: 22.75
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (2-439): 3.85e-131: 389: 21.30
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (7-422): 1.11e-127: 381: 24.40
+	At
		1091676 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPK3_ARATH (3-432): 3.05e-127: 380: 20.81
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (7-300): 1.27e-120: 363: 28.38
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (6-391): 5.26e-110: 335: 23.01
+	Hs
		1168524 RN19B_HUMAN (220-460): 6.9e-59: 207: 19.18		NEK9_HUMAN (5-302): 3.01e-52: 190: 36.84
+	Hs
		475987 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK8_HUMAN (6-270): 7.54e-54: 192: 40.23
+	Hs
		476090 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NEK9_HUMAN (5-302): 3.01e-52: 190: 36.84