HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: GBB1 (P62873)
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)
Gene: GNB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0044877 - protein-containing complex binding
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 340
+	Hs
		227099 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		228745 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (130-340): 2.9e-59: 196: 24.30
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		1334930 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (3-124): 6.68e-32: 126: 25.41
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (259-340): 1.35e-18: 87.8: 23.17
+	Hs
		196917 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (130-340): 2.9e-59: 196: 24.30
+	Hs
		475589 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB2_HUMAN (1-340): 1e-105: 314: 90.29
+	Hs
		476404 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GBB4_HUMAN (1-340): 6.23e-105: 312: 90.88
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (130-340): 2.9e-59: 196: 24.30
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (4-211): 4.16e-56: 187: 20.93
+	Hs
		196947 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		PRP4_HUMAN (51-253): 1.06e-12: 70.5: 25.85