HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: IF5A1 (P63241)
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)
Gene: EIF5A

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.686

Property	Details
Experiments	25959826, 32929329, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 154
+	Hs
		1219369 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		IF5A2_HUMAN (1-150): 2.09e-86: 251: 84.00
+	Sc
		477135 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		IF5A1_YEAST (1-154): 7.82e-83: 242: 62.58
+	Zm
		74562 Q41754_MAIZE (1-76): 8.11e-30: 121: 31.58		B4FDE1_MAIZE (3-153): 9.73e-79: 231: 56.49