Protein: ARHGQ
Rho guanine nucleotide exchange factor 26 (SH3 domain-containing guanine exchange factor)

Gene: ARHGQ, ARHGEF26
Organism: Homo sapiens
Interactions: 46
UniProt ID: Q96DR7

Gene Ontology (top 5):
GO:0001726 - ruffle
GO:0001886 - endothelial cell morphogenesis
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0032956 - regulation of actin cytoskeleton organization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

168732

CSKP
Peripheral plasma membrane protein CASK

4

19

High-throughput

0.881

High

1091552

DLG1
Disks large homolog 1

3

13

Small-scale

0.853

High

955464

CDC42
Cell division control protein 42 homolog

2

20

High-throughput

0.768

High

978221

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1368711

DLG3
Disks large homolog 3

1

13

High-throughput

0.691

High

1387793

LIN7C
Protein lin-7 homolog C

5

20

High-throughput

0.650

High

988602

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.647

High

1215347

DCAF8
DDB1- and CUL4-associated factor 8

2

10

High-throughput

0.628

High

375825

RASK
GTPase KRas

1

17

High-throughput

0.618

High

414384

P53
Cellular tumor antigen p53

1

5

High-throughput

0.618

High

541632

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.618

High

962367

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

725637

CPSM
Carbamoyl-phosphate synthase [ammonia], mitochondrial

3

3

High-throughput

0.609

High

856334

IF2M
Translation initiation factor IF-2, mitochondrial

3

4

High-throughput

0.609

High

401281

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

9

High-throughput

0.575

High

703680

MK01
Mitogen-activated protein kinase 1

2

4

High-throughput

0.571

High

1034315

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.553

High

1086743

RB40B
Ras-related protein Rab-40B

1

4

Small-scale

0.553

High

1387791

LIN7B
Protein lin-7 homolog B

2

20

High-throughput

0.549

High

1036676

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

20

High-throughput

0.536

High

1387787

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

1

High-throughput

0.536

High

775710

DEK
Protein DEK

2

1

High-throughput

0.521

High

1122308

SCRIB
Protein scribble homolog

2

18

High-throughput

0.521

High

1387797

LC7L2
Putative RNA-binding protein Luc7-like 2

2

2

High-throughput

0.521

High

1386073

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

1

High-throughput

0.489

High

445045

S10A9
Protein S100-A9

1

5

High-throughput

0.479

High

656219

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

9

High-throughput

0.479

High

1141853

EEA1
Early endosome antigen 1

1

8

High-throughput

0.479

High

1387795

RUVB1
RuvB-like 1

1

3

High-throughput

0.479

High

1358825

KBTB7
Kelch repeat and BTB domain-containing protein 7

1

5

High-throughput

0.445

High

553851

KCRU
Creatine kinase U-type, mitochondrial

1

1

High-throughput

0.437

High

1127073

RBM39
RNA-binding protein 39

1

8

High-throughput

0.437

High

1244571

SYDM
Aspartate--tRNA ligase, mitochondrial

1

1

High-throughput

0.437

High

1387789

XRN2
5'-3' exoribonuclease 2

1

2

High-throughput

0.437

High

1387792

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

1

High-throughput

0.437

High

1387796

RT07
Small ribosomal subunit protein uS7m

1

1

High-throughput

0.437

High

355274

ACL6A
Actin-like protein 6A

1

7

High-throughput

0.407

High

1210734

ZMYM1
Zinc finger MYM-type protein 1

1

2

High-throughput

0.407

High

1387788

WDR83
WD repeat domain-containing protein 83

1

8

High-throughput

0.407

High

662799

CPT2
Carnitine O-palmitoyltransferase 2, mitochondrial

2

0

High-throughput

0.318

High

1335903

PDPR
Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial

2

0

High-throughput

0.318

High

1387790

RSAD1
Radical S-adenosyl methionine domain-containing protein 1, mitochondrial

1

0

High-throughput

0.279

Low

1387794

TMLH
Trimethyllysine dioxygenase, mitochondrial

1

0

High-throughput

0.279

Low

643022

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

643248

MUTA
Methylmalonyl-CoA mutase, mitochondrial

1

0

High-throughput

0.249

Low

1207094

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025