HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: MMSA (Q02252)
Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (MMSDH) (EC 1.2.1.27) (Aldehyde dehydrogenase family 6 member A1) (Malonate-semialdehyde dehydrogenase [acylating])
Gene: ALDH6A1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	35509820
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005739 - mitochondrion
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 535
+	Hs
		226628 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL1B1_HUMAN (4-521): 0: 633: 29.33
+	Hs
		226248 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ALDH2_HUMAN (4-521): 0: 615: 28.57
+	Hs
		226104 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL1A2_HUMAN (12-521): 0: 608: 27.67
+	Hs
		226830 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL9A1_HUMAN (43-523): 0: 548: 28.04
+	Hs
		228667 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AL8A1_HUMAN (43-516): 0: 520: 30.63
+	Hs
		475384 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1B1_HUMAN (4-521): 0: 633: 29.33
+	Sc
		477355 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		ALDH2_YEAST (35-517): 0: 539: 27.64
+	At
		1092390 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2B4_ARATH (22-518): 0: 591: 28.23
+	At
		1091706 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		AL2C4_ARATH (35-528): 0: 558: 26.40
+	Hs
		475850 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AL1L2_HUMAN (5-516): 0: 549: 25.05