HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: BRD4 (O60885)
Bromodomain-containing protein 4 (Protein HUNK1)
Gene: BRD4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	28805820, 28805822, 31559706, 34133717, 34588438, 34599168, 34987184, 35512704
Identification Methods	affinity chromatography technology, pull down, enzymatic study, two hybrid, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 1362
+	Hs
		260633 KLH20_HUMAN (154-372): 8.68e-60: 204: 20.87		BRD4_HUMAN (1-1362): 1.08e-122: 416: 100.00
+	Hs
		227565 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		BRD3_HUMAN (37-737): 8.76e-57: 213: 47.73
+	Hs
		227378 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43
+	Dm
		1474013 RDX_DROME (1-374): 1.07e-112: 349: 79.41		Q9W1S2_DROME (341-458): 1.23e-36: 141: 37.29
+	Hs
		674382 KLH20_HUMAN (154-372): 8.68e-60: 204: 20.87		BRD2_HUMAN (3-737): 5.3e-54: 206: 46.43
+	Hs
		1121534 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		BRD7_HUMAN (238-731): 9.86e-30: 129: 10.56
+	Hs
		1086759 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		BPTF_HUMAN (67-161): 9.91e-11: 68.9: 41.05