HitPredict

Interactor 1: SPOP (O43791)
Speckle-type POZ protein (HIB homolog 1) (Roadkill homolog 1)
Gene: SPOP

Interactor 2: BRD3 (Q15059)
Bromodomain-containing protein 3 (RING3-like protein)
Gene: BRD3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	0.60	0.707

Property	Details
Experiments	28805820, 28805822, 31026449, 28805821
Identification Methods	affinity chromatography technology, pull down, two hybrid, x-ray crystallography
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 374 Hs			1 726
+	Hs
		227378 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		227271 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		674382 KLH20_HUMAN (154-372): 8.68e-60: 204: 20.87		BRD2_HUMAN (5-700): 8.79e-139: 429: 57.95
+	Hs
		227704 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		ZMYD8_HUMAN (3-713): 1.39e-58: 217: 12.28
+	Hs
		260633 KLH20_HUMAN (154-372): 8.68e-60: 204: 20.87		BRD4_HUMAN (3-644): 3.51e-104: 349: 52.55
+	Hs
		227568 SPOP_HUMAN (1-374): 2.72e-128: 374: 100.00		ZMY11_HUMAN (3-446): 3.19e-46: 176: 10.15
+	Dm
		1474013 RDX_DROME (1-374): 1.07e-112: 349: 79.41		Q9W1S2_DROME (26-226): 1.22e-39: 148: 24.02
+	Hs
		1067312 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		EP300_HUMAN (4-177): 1.06e-35: 148: 23.43
+	Ce
		1164953 MEL26_CAEEL (17-354): 6.76e-73: 233: 31.12		Q17581_CAEEL (28-314): 5.72e-23: 105: 14.78
+	Hs
		639729 KEAP1_HUMAN (132-363): 1.22e-55: 194: 22.36		TAF1_HUMAN (20-303): 4.78e-19: 94.5: 13.73