HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: RBBP4 (Q09028)
Histone-binding protein RBBP4 (Chromatin assembly factor 1 subunit C) (CAF-1 subunit C) (Chromatin assembly factor I p48 subunit) (CAF-I 48 kDa subunit) (CAF-I p48) (Nucleosome-remodeling factor subunit RBAP48) (Retinoblastoma-binding protein 4) (RBBP-4) (Retinoblastoma-binding protein p48)
Gene: RBBP4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005829 - cytosol GO:0042826 - histone deacetylase binding
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 425
+	Hs
		227583 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		RBBP7_HUMAN (1-425): 3.63e-115: 345: 89.20
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (109-424): 2.86e-60: 205: 16.52
+	Hs
		312590 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (153-417): 2.83e-46: 172: 15.23
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		228498 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (8-106): 1.77e-21: 98.3: 10.58
+	Hs
		475670 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		RBBP4_HUMAN (1-425): 4.3e-124: 367: 100.00
+	Sc
		477094 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		MSI1_YEAST (3-412): 4.81e-77: 247: 28.31
+	Hs
		312654 ARI2_HUMAN (222-464): 1.56e-64: 217: 20.82		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (267-425): 7.48e-35: 133: 25.61
+	Hs
		476280 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		GRWD1_HUMAN (263-425): 3.54e-26: 111: 23.56