Protein: PIDD1
p53-induced death domain-containing protein 1 (EC 3.4.21.-) (Leucine-rich repeat and death domain-containing protein) [Cleaved into: PIDD-N; PIDD-C; PIDD-CC]

Gene: PIDD1
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q9HB75

Gene Ontology (top 5):
GO:0004175 - endopeptidase activity
GO:0005123 - death receptor binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1008670

CRADD
Death domain-containing protein CRADD

8

1

Small-scale

0.960

High

840126

CASP2
Caspase-2

5

4

Small-scale

0.912

High

1109668

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

3

20

Small-scale

0.827

High

1096931

FADD
FAS-associated death domain protein

2

5

Small-scale

0.754

High

1407094

MDFI
MyoD family inhibitor

2

1

High-throughput

0.640

High

1008361

PRKDC
DNA-dependent protein kinase catalytic subunit

2

4

Small-scale

0.624

High

143702

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

1

14

Small-scale

0.618

High

1437996

PIDD1
p53-induced death domain-containing protein 1

1

20

Small-scale

0.618

High

1121529

KEAP1
Kelch-like ECH-associated protein 1

2

2

Small-scale

0.614

High

1409644

DHB14
L-fucose dehydrogenase

2

1

High-throughput

0.606

High

1277243

POGZ
Pogo transposable element with ZNF domain

2

0

High-throughput

0.580

High

1281090

KHDC4
KH homology domain-containing protein 4

2

0

High-throughput

0.580

High

620595

NUCL
Nucleolin

1

3

Small-scale

0.561

High

1102263

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.561

High

193349

MAFG
Transcription factor MafG

1

2

High-throughput

0.541

High

943744

SOX8
Transcription factor SOX-8

1

3

High-throughput

0.541

High

1144170

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.536

High

390261

FETA
Alpha-fetoprotein

1

0

High-throughput

0.518

High

1154596

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

1405590

TEAD3
Transcriptional enhancer factor TEF-5

1

0

High-throughput

0.518

High

1037381

H11
Histone H1.1

1

2

High-throughput

0.515

High

1162050

H31T
Histone H3.1t

1

3

High-throughput

0.515

High

351607

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

4

High-throughput

0.494

High

124500

HAX1
HCLS1-associated protein X-1

1

2

Small-scale

0.479

High

384732

CRYAB
Alpha-crystallin B chain

1

3

Small-scale

0.479

High

551269

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.479

High

756357

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

769785

RFC4
Replication factor C subunit 4

1

1

Small-scale

0.479

High

829158

RFC5
Replication factor C subunit 5

1

1

Small-scale

0.479

High

1057265

PRDX1
Peroxiredoxin-1

1

1

Small-scale

0.479

High

1093432

TRI32
E3 ubiquitin-protein ligase TRIM32

1

5

Small-scale

0.479

High

1157940

DDB1
DNA damage-binding protein 1

1

1

Small-scale

0.479

High

1220816

RN123
E3 ubiquitin-protein ligase RNF123

1

6

High-throughput

0.479

High

1360622

MADD
MAP kinase-activating death domain protein

1

2

Small-scale

0.479

High

1366749

AN32B
Acidic leucine-rich nuclear phosphoprotein 32 family member B

1

20

Small-scale

0.479

High

1435170

RPAP3
RNA polymerase II-associated protein 3

1

7

Small-scale

0.479

High

1437999

NEMO
NF-kappa-B essential modulator

1

7

Small-scale

0.479

High

880968

MTR1B
Melatonin receptor type 1B

1

2

High-throughput

0.464

High

348746

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

Small-scale

0.458

High

611696

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

Small-scale

0.458

High

703068

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.458

High

704759

ERCC5
DNA excision repair protein ERCC-5

1

0

Small-scale

0.458

High

723099

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

Small-scale

0.458

High

1323467

NUP93
Nuclear pore complex protein Nup93

1

0

Small-scale

0.458

High

1433777

SENP3
Sentrin-specific protease 3

1

0

Small-scale

0.458

High

1437997

FANCI
Fanconi anemia group I protein

1

0

Small-scale

0.458

High

1437998

TELO2
Telomere length regulation protein TEL2 homolog

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025