HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WDR43 (Q15061)
WD repeat-containing protein 43 (U3 small nucleolar RNA-associated protein 5 homolog)
Gene: WDR43

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.50	0.437

Property	Details
Experiments	35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	-
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 677
+	Hs
		228276 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		FBXW7_HUMAN (5-295): 1.2e-60: 217: 16.13
+	Hs
		227054 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR5_HUMAN (157-440): 1.42e-43: 161: 12.11
+	Hs
		228868 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NLE1_HUMAN (199-562): 4.61e-28: 120: 9.69
+	Hs
		227540 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TAF5_HUMAN (7-110): 4.76e-26: 116: 15.00
+	Hs
		226950 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		COPA_HUMAN (161-341): 2.58e-24: 111: 10.93
+	Hs
		229068 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		WDR3_HUMAN (9-463): 1.11e-24: 111: 7.53
+	Hs
		226765 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LIS1_HUMAN (204-437): 1.57e-18: 90.3: 9.40
+	Hs
		228555 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KTNB1_HUMAN (124-301): 2.1e-17: 88.5: 16.02
+	Hs
		227617 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SMU1_HUMAN (117-336): 2.99e-15: 81.1: 18.62
+	Hs
		228315 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SNR40_HUMAN (251-417): 1.07e-13: 74.8: 4.74
+	Hs
		228612 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TBL1R_HUMAN (250-418): 3.33e-11: 68.3: 8.15
+	Hs
		1281514 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		FBXW7_HUMAN (5-295): 1.2e-60: 217: 16.13
+	Hs
		863478 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		COPA_HUMAN (161-341): 2.58e-24: 111: 10.93
+	Hs
		1219356 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SNR40_HUMAN (251-417): 1.07e-13: 74.8: 4.74
+	Hs
		476151 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		FBXW7_HUMAN (5-295): 1.2e-60: 217: 16.13
+	Sc
		477239 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		TAF5_YEAST (78-354): 1.69e-21: 101: 18.07
+	Hs
		475563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		WDR5_HUMAN (157-440): 1.42e-43: 161: 12.11
+	Hs
		475845 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SMU1_HUMAN (117-336): 2.99e-15: 81.1: 18.62
+	Hs
		476181 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SNR40_HUMAN (251-417): 1.07e-13: 74.8: 4.74