HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SF3A2 (Q15428)
Splicing factor 3A subunit 2 (SF3a66) (Spliceosome-associated protein 62) (SAP 62)
Gene: SF3A2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	35509820, 35987950, 35256949
Identification Methods	affinity chromatography technology, proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0008270 - zinc ion binding GO:0016607 - nuclear speck
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 464
+	Hs
		228700 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		ZN768_HUMAN (277-449): 2.74e-22: 101: 27.32
+	Hs
		226120 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC31A_HUMAN (172-463): 1.67e-21: 100: 15.33
+	Hs
		228101 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KMT2C_HUMAN (73-462): 1.38e-16: 85.1: 12.59
+	Hs
		229228 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PCLO_HUMAN (152-461): 4.35e-13: 73.9: 16.76
+	Hs
		226957 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SC24C_HUMAN (120-446): 3.28e-12: 70.8: 19.39
+	Hs
		228210 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		TITIN_HUMAN (290-460): 7.67e-09: 60.4: 18.50
+	Mm
		88466 PRKN_MOUSE (1-465): 6.53e-131: 388: 83.66		D3Z656_MOUSE (199-425): 3.05e-11: 68.1: 17.54
+	Hs
		302333 ARI1_HUMAN (163-464): 3.95e-74: 244: 19.67		SC31A_HUMAN (172-463): 1.67e-21: 100: 15.33
+	Hs
		302245 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SC31A_HUMAN (172-463): 1.67e-21: 100: 15.33
+	Hs
		475943 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		OTOG_HUMAN (67-449): 3.85e-13: 74.3: 14.14
+	At
		1092118 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		Q9LIE8_ARATH (100-464): 2.85e-10: 65.1: 15.28
+	At
		1092316 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24A_ARATH (229-459): 2.55e-10: 65.1: 21.52
+	At
		1091778 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC31B_ARATH (139-346): 4.22e-10: 64.3: 16.04
+	At
		1092229 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SC24C_ARATH (222-461): 9.12e-09: 60: 21.99