HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PKN1 (Q16512)
Serine/threonine-protein kinase N1 (EC 2.7.11.13) (Protease-activated kinase 1) (PAK-1) (Protein kinase C-like 1) (Protein kinase C-like PKN) (Protein kinase PKN-alpha) (Protein-kinase C-related kinase 1) (Serine-threonine protein kinase N)
Gene: PKN1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0001933 - negative regulation of protein phosphorylation GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0042826 - histone deacetylase binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 942
+	Hs
		227575 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PKN2_HUMAN (6-942): 0: 1018: 56.41
+	Hs
		227800 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		PKN3_HUMAN (36-939): 0: 867: 49.84
+	Hs
		226260 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCB_HUMAN (462-940): 3.02e-167: 505: 36.12
+	Hs
		226455 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCA_HUMAN (452-940): 6.34e-166: 502: 36.13
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (564-940): 4.13e-154: 464: 40.42
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (587-941): 7.64e-153: 461: 43.06
+	Hs
		227208 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCE_HUMAN (484-937): 3.81e-147: 455: 35.41
+	Hs
		227243 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KPCD_HUMAN (608-938): 7.48e-103: 337: 50.30
+	Hs
		408678 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		KPCB_HUMAN (462-940): 3.02e-167: 505: 36.12
+	Hs
		566475 HOIL1_HUMAN (12-448): 5.59e-68: 227: 16.36		KPCA_HUMAN (452-940): 6.34e-166: 502: 36.13
+	Rn
		934618 HOIL1_RAT (12-448): 8.73e-66: 221: 17.05		KPCB_RAT (462-940): 4.75e-166: 502: 35.92
+	Hs
		227519 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A2_HUMAN (513-922): 7.5e-95: 317: 24.30
+	Hs
		408534 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		KPCB_HUMAN (462-940): 3.02e-167: 505: 36.12
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (587-941): 7.64e-153: 461: 43.06
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (564-940): 4.13e-154: 464: 40.42
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (587-941): 7.64e-153: 461: 43.06
+	Hs
		408535 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPCB_HUMAN (462-940): 3.02e-167: 505: 36.12
+	Hs
		475314 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KPCA_HUMAN (452-940): 6.34e-166: 502: 36.13
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (587-941): 7.64e-153: 461: 43.06