HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: SRPK1 (Q96SB4)
SRSF protein kinase 1 (EC 2.7.11.1) (SFRS protein kinase 1) (Serine/arginine-rich protein-specific kinase 1) (SR-protein-specific kinase 1)
Gene: SRPK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005783 - endoplasmic reticulum GO:0005829 - cytosol GO:0016607 - nuclear speck
Homologous interactions	12

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 655
+	Hs
		227143 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		SRPK2_HUMAN (48-655): 9.43e-136: 415: 57.97
+	Hs
		227531 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A1_HUMAN (1-359): 2.84e-81: 273: 14.32
+	Hs
		226918 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A3_HUMAN (1-353): 1.92e-78: 266: 13.83
+	Hs
		227519 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KS6A2_HUMAN (1-374): 1.21e-78: 266: 14.00
+	Hs
		226557 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		CDK2_HUMAN (414-653): 1.01e-65: 219: 19.43
+	Hs
		229151 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DYR1B_HUMAN (487-654): 5.25e-53: 194: 26.32
+	Hs
		226582 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK3_HUMAN (409-655): 3.06e-47: 179: 12.65
+	Hs
		227863 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		MARK2_HUMAN (409-654): 1.03e-46: 178: 12.70
+	Hs
		833768 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		CLK1_HUMAN (436-654): 8.6e-61: 212: 23.45
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (414-655): 1.8e-57: 204: 13.71
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (414-655): 1.35e-54: 196: 15.32
+	Sc
		419769 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SNF1_YEAST (451-654): 7.1e-16: 83.3: 15.24