HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: HCD2 (Q99714)
3-hydroxyacyl-CoA dehydrogenase type-2 (EC 1.1.1.35) (17-beta-estradiol 17-dehydrogenase) (EC 1.1.1.62) (2-methyl-3-hydroxybutyryl-CoA dehydrogenase) (MHBD) (3-alpha-(17-beta)-hydroxysteroid dehydrogenase (NAD(+))) (EC 1.1.1.239) (3-hydroxy-2-methylbutyryl-CoA dehydrogenase) (EC 1.1.1.178) (3-hydroxyacyl-CoA dehydrogenase type II) (3alpha(or 20beta)-hydroxysteroid dehydrogenase) (EC 1.1.1.53) (7-alpha-hydroxysteroid dehydrogenase) (EC 1.1.1.159) (Endoplasmic reticulum-associated amyloid beta-peptide-binding protein) (Mitochondrial ribonuclease P protein 2) (Mitochondrial RNase P protein 2) (Short chain dehydrogenase/reductase family 5C member 1) (Short-chain type dehydrogenase/reductase XH98G2) (Type II HADH)
Gene: HSD17B10

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.73	0.60	0.662

Property	Details
Experiments	25591737, 35509820, 35256949
Identification Methods	fluorescent resonance energy transfer, pull down, enzymatic study, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005739 - mitochondrion GO:0005829 - cytosol GO:0007005 - mitochondrion organization
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 261
+	Hs
		227350 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		DHRS2_HUMAN (8-255): 1.01e-71: 222: 25.10
+	At
		97042 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		SDR4_ARATH (1-259): 2.33e-71: 222: 26.69
+	Hs
		476449 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		DECR2_HUMAN (12-256): 6.71e-17: 80.1: 30.32