Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.98 1.00 0.992

The method score is based on:

Property Details
Experiments 24357652, 19966284, 25474007, 25591737, 26162776, 26116755, 17052189, 27605430, 28945249, 29330382, 33730565, 35509820, 35256949, 19358826, 19229105, 22724072, 19880420, 27528605, 20798600, 19167501 and 4 others

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Identification Methods affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation
Interaction Type physical association, direct interaction, association

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~ubiquitin
Common GO terms GO:0000422 - autophagy of mitochondrion
GO:0000423 - mitophagy
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
and 31 others

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Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 465
Hs

1 581
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024