Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN
Interactor 2: PINK1 (Q9BXM7)
Serine/threonine-protein kinase PINK1, mitochondrial (EC 2.7.11.1) (BRPK) (PTEN-induced putative kinase protein 1)
Gene: PINK1
Species: Homo sapiens
Source: mint
Category: Small-scale
Confidence: High
Method score | Annotation score | Interaction score |
---|---|---|
0.98 | 1.00 | 0.992 |
The method score is based on:
Property | Details |
---|---|
Experiments | 24357652, 19966284, 25474007, 25591737, 26162776, 26116755, 17052189, 27605430, 28945249, 29330382, 33730565, 35509820, 35256949, 19358826, 19229105, 22724072, 19880420, 27528605, 20798600, 19167501 and 4 others
more... |
Identification Methods | affinity chromatography technology, enzymatic study, fluorescent resonance energy transfer, pull down, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation |
Interaction Type | physical association, direct interaction, association |
The annotation score is based on:
Property | Details |
---|---|
Interacting Pfam domains | Pkinase~ubiquitin |
Common GO terms | GO:0000422 - autophagy of mitochondrion GO:0000423 - mitophagy GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005739 - mitochondrion and 31 others more... |
Homologous interactions | 20 |
Homologous interactions (Top 20)
Color coding for hit scores
Service provided by Combinatics, Japan
Last updated: 15 Jul 2024