HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: WNK1 (Q9H4A3)
Serine/threonine-protein kinase WNK1 (EC 2.7.11.1) (Erythrocyte 65 kDa protein) (p65) (Kinase deficient protein) (Protein kinase lysine-deficient 1) (Protein kinase with no lysine 1) (hWNK1)
Gene: WNK1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35987950, 35256949
Identification Methods	proximity labelling technology, affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	Pkinase~ubiquitin
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019901 - protein kinase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 2382
+	Hs
		226638 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT2_HUMAN (105-548): 1.79e-126: 409: 17.22
+	Hs
		227381 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2D_HUMAN (219-633): 6.74e-126: 408: 19.91
+	Hs
		227330 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AAPK1_HUMAN (195-737): 1.29e-123: 404: 16.40
+	Hs
		229082 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		KCC2A_HUMAN (219-633): 2.85e-124: 403: 18.96
+	Hs
		226637 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Hs
		682055 RNF14_HUMAN (161-464): 6.69e-69: 229: 21.56		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	Sc
		419769 UBI4P_YEAST (1-229): 3.48e-61: 205: 18.72		SNF1_YEAST (221-671): 1.23e-123: 407: 21.96
+	Hs
		474936 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT2_HUMAN (105-548): 1.79e-126: 409: 17.22
+	Hs
		474935 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	At
		1091641 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN10_ARATH (220-614): 3.87e-128: 415: 19.55
+	Hs
		475723 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		KCC2D_HUMAN (219-633): 6.74e-126: 408: 19.91
+	Hs
		475390 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		AKT1_HUMAN (159-548): 6.99e-124: 402: 18.55
+	At
		1091642 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		CDPKB_ARATH (197-579): 1.2e-123: 402: 17.69
+	At
		955189 UBQ3_ARATH (1-77): 1.22e-30: 122: 31.17		KIN11_ARATH (221-566): 2.92e-123: 401: 21.07
+	Hs
		228996 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NRBP_HUMAN (234-476): 4.38e-26: 117: 34.26
+	Hs
		228149 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		NEK7_HUMAN (221-467): 5.66e-24: 106: 29.30