HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: ES8L2 (Q9H6S3)
Epidermal growth factor receptor kinase substrate 8-like protein 2 (EPS8-like protein 2) (Epidermal growth factor receptor pathway substrate 8-related protein 2) (EPS8-related protein 2)
Gene: EPS8L2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	1.00	0.754

Property	Details
Experiments	35509820, 35256949
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH3_1~ubiquitin
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 465 Hs			1 715
+	Hs
		226294 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		YES_HUMAN (381-709): 1.86e-76: 257: 15.22
+	Hs
		226295 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		LYN_HUMAN (431-709): 1.93e-62: 218: 13.64
+	Hs
		226084 PRKN_HUMAN (1-465): 7.37e-137: 403: 100.00		STAM2_HUMAN (337-607): 1.59e-54: 197: 18.75
+	Hs
		523051 CUL9_HUMAN (30-463): 1.19e-80: 274: 18.58		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		276992 UBB_HUMAN (1-234): 1.14e-59: 197: 17.92		STAM2_HUMAN (337-607): 1.59e-54: 197: 18.75
+	Hs
		475292 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		SRC_HUMAN (425-709): 1.22e-68: 236: 14.04
+	Hs
		411563 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		LCK_HUMAN (416-715): 1.35e-60: 213: 12.79
+	Hs
		276993 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		STAM2_HUMAN (337-607): 1.59e-54: 197: 18.75
+	Hs
		208981 UBC_HUMAN (1-77): 1.15e-29: 124: 32.47		NCK2_HUMAN (492-556): 5.48e-20: 94.5: 30.77