HitPredict

Interactor 1: PRKN (O60260)
E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)
Gene: PRKN

Interactor 2: FAF1 (Q9UNN5)
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)
Gene: FAF1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.866

The method score is based on:

Property Details
Experiments 23307929, 29223129, 35256949
Identification Methods affinity chromatography technology, pull down, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains UBA_4~ubiquitin
Common GO terms GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0019901 - protein kinase binding
GO:0031072 - heat shock protein binding
and 6 others

more...
Homologous interactions 14

Homologous interactions

Color coding for hit scores

1 465
Hs

1 650
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Service provided by Combinatics, Japan

Last updated: 15 Jul 2024