HitPredict

Interactor 1: SMCA5 (O60264)
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin A5) (EC 3.6.4.-) (Sucrose nonfermenting protein 2 homolog) (hSNF2H)
Gene: SMARCA5

Interactor 2: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	29955894, 32068487
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003677 - DNA binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006281 - DNA repair GO:0006325 - chromatin organization
Homologous interactions	14

Homologous interactions

Color coding for hit scores

	1 1052 Hs			1 835
+	Hs
		658668 SMCA1_HUMAN (71-1030): 0: 1042: 85.29		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1018456 CHD3_HUMAN (8-1052): 0: 801: 26.23		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		229523 SMCA5_HUMAN (19-1052): 0: 1097: 100.00		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		1029433 CHD4_HUMAN (14-945): 0: 769: 26.95		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		846956 SMCA4_HUMAN (63-960): 0: 696: 29.09		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Mm
		1111935 SMCA4_MOUSE (63-936): 0: 725: 30.53		TIF1B_MOUSE (57-835): 5.81e-159: 486: 94.87
+	Hs
		668690 CHD4_HUMAN (14-945): 0: 769: 26.95		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		1059944 CHD4_HUMAN (14-945): 0: 769: 26.95		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		668993 CHD8_HUMAN (6-1031): 0: 758: 26.13		PML_HUMAN (29-609): 1.21e-57: 214: 14.00
+	Hs
		151520 CHD2_HUMAN (10-1037): 0: 705: 28.83		TRIM1_HUMAN (40-589): 4.03e-64: 231: 15.36
+	Hs
		846767 SMCA2_HUMAN (161-654): 4.23e-122: 411: 44.02		TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00
+	Hs
		1203241 CHD1L_HUMAN (175-867): 0: 711: 38.23		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		847115 SMCA4_HUMAN (63-960): 0: 696: 29.09		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32
+	Hs
		846897 SMCA2_HUMAN (161-654): 4.23e-122: 411: 44.02		TRI33_HUMAN (406-826): 1.6e-54: 206: 19.32