Protein: IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase subunit alpha) (NAD(+)-specific ICDH subunit alpha)

Gene: IDH3A
Organism: Homo sapiens
Interactions: 90
UniProt ID: P50213

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

229422

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

6

15

Small-scale

0.947

High

893598

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

6

16

Small-scale

0.944

High

893597

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

2

16

High-throughput

0.754

High

241101

PRKN
E3 ubiquitin-protein ligase parkin

2

7

High-throughput

0.584

High

893616

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

2

High-throughput

0.584

High

893643

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.541

High

371486

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.536

High

484435

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.536

High

563431

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.536

High

724005

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.536

High

893603

DMWD
Dystrophia myotonica WD repeat-containing protein

1

9

High-throughput

0.536

High

893625

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

105584

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

361171

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

630723

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.494

High

321466

PRP6
Pre-mRNA-processing factor 6

1

2

High-throughput

0.481

High

893615

SF01
Splicing factor 1

1

1

High-throughput

0.481

High

362979

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

458334

ADRB2
Beta-2 adrenergic receptor

1

3

High-throughput

0.479

High

606437

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

694939

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

731089

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

760821

GLYC
Serine hydroxymethyltransferase, cytosolic

1

1

Small-scale

0.479

High

828712

MDHM
Malate dehydrogenase, mitochondrial

1

8

High-throughput

0.479

High

830351

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

893599

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.479

High

893601

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

893604

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

893606

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

893607

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

893608

CUL3
Cullin-3

1

1

High-throughput

0.479

High

893612

KIF14
Kinesin-like protein KIF14

1

3

High-throughput

0.479

High

893613

PDK1
[Pyruvate dehydrogenase

1

2

High-throughput

0.479

High

893614

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.479

High

893628

RDH13
Retinol dehydrogenase 13

1

3

High-throughput

0.479

High

893629

SERB1
SERPINE1 mRNA-binding protein 1

1

2

High-throughput

0.479

High

893630

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

893632

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

893638

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

1

High-throughput

0.479

High

893640

MTG2
Mitochondrial ribosome-associated GTPase 2

1

2

High-throughput

0.479

High

893645

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

893648

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

893649

UBQL2
Ubiquilin-2

1

2

High-throughput

0.479

High

408743

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.458

High

445785

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

664684

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

841657

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851849

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

893600

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.458

High

893602

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

893620

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

893624

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

893633

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

893636

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

893646

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

893651

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.458

High

974

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.445

High

529354

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

541002

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.445

High

893605

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.445

High

893611

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

1

Small-scale

0.445

High

893618

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

893626

DND1
Dead end protein homolog 1

1

1

High-throughput

0.445

High

893634

AURKB
Aurora kinase B

1

3

High-throughput

0.445

High

893635

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

2

High-throughput

0.445

High

893644

DDX28
Probable ATP-dependent RNA helicase DDX28

1

4

High-throughput

0.445

High

767708

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

878784

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

893610

CUL7
Cullin-7

1

1

High-throughput

0.437

High

893617

CL16A
Protein CLEC16A

1

2

High-throughput

0.437

High

893621

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.437

High

893622

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

893641

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

142308

PEX7
Peroxisomal targeting signal 2 receptor

1

11

High-throughput

0.407

High

330081

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.407

High

628612

CAP7
Azurocidin

1

9

High-throughput

0.407

High

893619

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

893627

TTC9C
Tetratricopeptide repeat protein 9C

1

1

High-throughput

0.407

High

893631

LPAR1
Lysophosphatidic acid receptor 1

1

6

High-throughput

0.407

High

893639

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

893642

ITM2C
Integral membrane protein 2C

1

6

High-throughput

0.407

High

893623

KDM3B
Lysine-specific demethylase 3B

1

0

High-throughput

0.279

Low

893637

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

48227

TM129
E3 ubiquitin-protein ligase TM129

1

0

High-throughput

0.249

Low

345532

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.249

Low

893609

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

893647

DHCR7
7-dehydrocholesterol reductase

1

0

High-throughput

0.249

Low

404729

PRIO
Major prion protein

1

0

High-throughput

0.232

Low

893650

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025