HitPredict

Interactor 1: NUAK1 (O60285)
NUAK family SNF1-like kinase 1 (EC 2.7.11.1) (AMPK-related protein kinase 5) (ARK5) (Omphalocele kinase 1)
Gene: NUAK1

Interactor 2: LATS1 (O95835)
Serine/threonine-protein kinase LATS1 (EC 2.7.11.1) (Large tumor suppressor homolog 1) (WARTS protein kinase) (h-warts)
Gene: LATS1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.55	1.00	0.747

Property	Details
Experiments	19927127
Identification Methods	affinity chromatography technology, enzymatic study, anti bait coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Pkinase~Pkinase, Pkinase~Pkinase_C, Pkinase~UBA
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0006468 - protein phosphorylation GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 661 Hs			1 1130
+	Mm
		1207481 MARK4_MOUSE (4-655): 2.73e-155: 468: 27.01		LATS1_MOUSE (1-1130): 0: 922: 93.10
+	Hs
		325884 NUAK2_HUMAN (1-661): 2.59e-148: 445: 49.92		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		325917 MARK1_HUMAN (4-658): 1.87e-140: 431: 24.32		LATS1_HUMAN (1-1130): 0: 934: 100.00
+	Hs
		229926 NUAK1_HUMAN (1-661): 0: 581: 100.00		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		229920 NUAK1_HUMAN (1-661): 0: 581: 100.00		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		229922 NUAK1_HUMAN (1-661): 0: 581: 100.00		KAPCB_HUMAN (661-1055): 5.19e-133: 410: 31.58
+	Hs
		681985 MARK4_HUMAN (4-655): 1.51e-155: 468: 27.16		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		681915 MARK2_HUMAN (1-658): 9.28e-152: 460: 23.88		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		568551 MARK3_HUMAN (4-658): 1.17e-156: 471: 27.09		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		568714 MARK2_HUMAN (1-658): 9.28e-152: 460: 23.88		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		681833 KCC2D_HUMAN (50-557): 3.32e-142: 425: 23.55		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		682081 AKT3_HUMAN (27-383): 1.88e-137: 412: 28.57		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		682218 AKT3_HUMAN (27-383): 1.88e-137: 412: 28.57		AKT2_HUMAN (603-1075): 3.93e-140: 433: 25.31
+	Sc
		419802 SNF1_YEAST (55-509): 1.88e-132: 405: 29.98		DBF2_YEAST (577-1088): 7.63e-136: 425: 30.83
+	Hs
		681760 SIK1_HUMAN (55-306): 4.6e-69: 241: 47.83		AKT1_HUMAN (595-1081): 5.84e-141: 435: 24.50
+	Hs
		568839 SIK3_HUMAN (35-309): 9.42e-68: 243: 46.01		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59
+	Hs
		568603 SIK1_HUMAN (55-306): 4.6e-69: 241: 47.83		KAPCA_HUMAN (661-1058): 6.14e-138: 422: 31.59