Protein: SAHH
Adenosylhomocysteinase (AdoHcyase) (EC 3.13.2.1) (S-adenosyl-L-homocysteine hydrolase)

Gene: SAHH, AHCY
Organism: Homo sapiens
Interactions: 181
UniProt ID: P23526

Gene Ontology (top 5):
GO:0004013 - adenosylhomocysteinase activity
GO:0005634 - nucleus
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0006730 - one-carbon metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

229955

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

3

10

High-throughput

0.861

High

659733

SAHH
Adenosylhomocysteinase

2

10

High-throughput

0.793

High

659828

CA050
Uncharacterized protein C1orf50

10

2

High-throughput

0.692

High

659819

SAHH3
Adenosylhomocysteinase 3

1

10

High-throughput

0.691

High

659793

ANR40
Ankyrin repeat domain-containing protein 40

7

1

High-throughput

0.688

High

240773

PRKN
E3 ubiquitin-protein ligase parkin

3

4

High-throughput

0.656

High

563210

CFTR
Cystic fibrosis transmembrane conductance regulator

3

1

High-throughput

0.650

High

413204

P53
Cellular tumor antigen p53

2

3

Small-scale

0.611

High

400289

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.584

High

659792

A16L1
Autophagy-related protein 16-1

2

2

High-throughput

0.584

High

659803

HSC20
Iron-sulfur cluster co-chaperone protein HscB

2

0

Small-scale

0.580

High

352972

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

659756

TERA
Transitional endoplasmic reticulum ATPase

2

2

High-throughput

0.571

High

659835

MLP3B
Microtubule-associated protein 1 light chain 3 beta

2

5

Small-scale

0.571

High

659831

ACE2
Angiotensin-converting enzyme 2

2

0

High-throughput

0.559

High

659816

APBP2
Amyloid protein-binding protein 2

1

0

High-throughput

0.549

High

659748

HSP13
Heat shock 70 kDa protein 13

1

3

High-throughput

0.541

High

171669

GAK
Cyclin-G-associated kinase

1

4

High-throughput

0.536

High

370564

FOS
Protein c-Fos

1

11

High-throughput

0.536

High

479111

ENOG
Gamma-enolase

1

1

High-throughput

0.536

High

529098

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.536

High

583454

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

7

High-throughput

0.536

High

659743

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

4

High-throughput

0.536

High

659762

FOXK1
Forkhead box protein K1

1

9

High-throughput

0.536

High

659778

CUL1
Cullin-1

1

2

High-throughput

0.536

High

659779

CUL3
Cullin-3

1

2

High-throughput

0.536

High

659780

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

659788

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.536

High

659810

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.536

High

659817

CSN5
COP9 signalosome complex subunit 5

1

3

High-throughput

0.536

High

659840

E41L5
Band 4.1-like protein 5

1

3

High-throughput

0.536

High

105358

APRIO
Alternative prion protein

2

2

High-throughput

0.533

High

659754

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.529

High

659749

PAXI
Paxillin

1

0

High-throughput

0.518

High

135497

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

187290

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

0

High-throughput

0.513

High

213814

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

321180

ERLN2
Erlin-2

1

0

High-throughput

0.513

High

659768

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

659801

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

659806

LMBL4
Lethal(3)malignant brain tumor-like protein 4

1

0

High-throughput

0.513

High

659832

KPCD2
Serine/threonine-protein kinase D2

1

0

High-throughput

0.513

High

659837

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.513

High

507536

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.501

High

659735

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

125239

LEG9
Galectin-9

1

1

High-throughput

0.479

High

186699

P73
Tumor protein p73

1

3

High-throughput

0.479

High

315127

RECQ4
ATP-dependent DNA helicase Q4

1

1

High-throughput

0.479

High

324537

HEXI1
Protein HEXIM1

1

4

High-throughput

0.479

High

348368

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

371181

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

405798

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.479

High

439643

INSR
Insulin receptor

1

9

High-throughput

0.479

High

472460

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.479

High

536517

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

577619

PLAK
Junction plakoglobin

1

1

High-throughput

0.479

High

587935

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

605555

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.479

High

606235

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

609580

LEG3
Galectin-3

1

1

Small-scale

0.479

High

659736

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

659737

PML
Protein PML

1

2

High-throughput

0.479

High

659738

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.479

High

659740

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

659742

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

659744

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

659746

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

659747

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

659751

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

659753

ATX3
Ataxin-3

1

4

High-throughput

0.479

High

659755

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.479

High

659758

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

5

Small-scale

0.479

High

659760

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

659761

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

659766

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

659769

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

659772

FOXC1
Forkhead box protein C1

1

9

High-throughput

0.479

High

659773

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

1

High-throughput

0.479

High

659775

PAK2
Serine/threonine-protein kinase PAK 2

1

3

High-throughput

0.479

High

659776

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

659781

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

659786

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

1

High-throughput

0.479

High

659787

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

659794

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

659798

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

659808

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.479

High

659809

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

659813

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

659814

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

High-throughput

0.479

High

659815

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

659823

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

659824

NECD
Necdin

1

1

High-throughput

0.479

High

659825

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

659826

ERP44
Endoplasmic reticulum resident protein 44

1

1

High-throughput

0.479

High

659829

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

4

High-throughput

0.479

High

659830

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

659850

HDAC6
Protein deacetylase HDAC6

1

1

High-throughput

0.479

High

659852

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

659853

MYO6
Unconventional myosin-VI

1

1

High-throughput

0.479

High

659854

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

659859

TRAF6
TNF receptor-associated factor 6

1

3

High-throughput

0.479

High

319404

UFL1
E3 UFM1-protein ligase 1

1

0

Small-scale

0.460

High

659752

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.460

High

176940

CE290
Centrosomal protein of 290 kDa

1

0

High-throughput

0.458

High

224624

ACTN4
Alpha-actinin-4

1

0

High-throughput

0.458

High

227374

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

257340

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

277150

ZN217
Zinc finger protein 217

1

0

High-throughput

0.458

High

345382

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

379875

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.458

High

482318

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.458

High

659352

CRCM
Colorectal mutant cancer protein

1

0

High-throughput

0.458

High

659734

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

659739

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

659745

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

659757

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

659759

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

659763

DAB2
Disabled homolog 2

1

0

Small-scale

0.458

High

659764

VIGLN
Vigilin

1

0

High-throughput

0.458

High

659765

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

659770

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

659771

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.458

High

659774

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

659777

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

659783

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

659784

CUL7
Cullin-7

1

0

High-throughput

0.458

High

659785

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

659789

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

659796

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

659799

LBN
Limbin

1

0

High-throughput

0.458

High

659800

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

659807

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

659811

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.458

High

659820

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

659821

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

659822

ASB16
Ankyrin repeat and SOCS box protein 16

1

0

High-throughput

0.458

High

659827

DERL1
Derlin-1

1

0

Small-scale

0.458

High

659841

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

659842

ANLN
Anillin

1

0

High-throughput

0.458

High

659843

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

659847

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

659848

RCC2
Protein RCC2

1

0

High-throughput

0.458

High

659856

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

659858

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

184583

MK13
Mitogen-activated protein kinase 13

1

1

Small-scale

0.445

High

327803

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

5

High-throughput

0.445

High

429316

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

659791

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

659836

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

5

High-throughput

0.445

High

659838

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

5

High-throughput

0.445

High

659855

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

254522

EIF1B
Eukaryotic translation initiation factor 1b

1

1

High-throughput

0.437

High

294826

BCAR3
Breast cancer anti-estrogen resistance protein 3

1

1

High-throughput

0.437

High

411370

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

642623

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.437

High

659741

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

659782

RBM39
RNA-binding protein 39

1

3

High-throughput

0.437

High

659795

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

659797

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

659802

GOLI
E3 ubiquitin-protein ligase RNF130

1

2

High-throughput

0.437

High

659804

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.437

High

659805

NIN
Ninein

1

2

High-throughput

0.437

High

659834

ASXL3
Putative Polycomb group protein ASXL3

1

1

High-throughput

0.437

High

659839

PKHA4
Pleckstrin homology domain-containing family A member 4

1

4

High-throughput

0.437

High

659849

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.437

High

659851

SAE2
SUMO-activating enzyme subunit 2

1

1

High-throughput

0.437

High

404673

PRIO
Major prion protein

1

0

High-throughput

0.426

High

659750

CEBPA
CCAAT/enhancer-binding protein alpha

1

4

High-throughput

0.408

High

117320

K7ERW4
Ankyrin repeat domain 40

1

1

High-throughput

0.407

High

659833

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.407

High

659845

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.288

High

659812

MIPT3
TRAF3-interacting protein 1

1

0

Small-scale

0.279

Low

659818

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.269

Low

65694

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.249

Low

245311

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.249

Low

659790

E2F4
Transcription factor E2F4

1

0

High-throughput

0.249

Low

659844

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

659846

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low

659857

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

659767

P
P protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025