HitPredict

Interactor 1: SI1L3 (O60292)
Signal-induced proliferation-associated 1-like protein 3 (SIPA1-like protein 3) (SPA-1-like protein 3)
Gene: SIPA1L3

Interactor 2: AFAD (P55196)
Afadin (ALL1-fused gene from chromosome 6 protein) (Protein AF-6) (Afadin adherens junction formation factor)
Gene: AFDN

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	34079125
Identification Methods	proximity labelling technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~PDZ
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1781 Hs			1 1824
+	Hs
		876525 SI1L2_HUMAN (1-1774): 0: 1393: 43.94		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		196421 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		812870 RPGP1_HUMAN (401-842): 1.03e-112: 375: 31.01		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		230245 SI1L3_HUMAN (1-1781): 0: 1374: 100.00		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Hs
		196511 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		KI13B_HUMAN (184-691): 5.1e-66: 250: 12.64
+	Hs
		297818 K0754_HUMAN (983-1458): 5.9e-32: 139: 10.74		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		876450 DLG5_HUMAN (1042-1430): 3.08e-09: 64.4: 9.23		AFAD_HUMAN (1-1824): 0: 1279: 100.00
+	Hs
		196430 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		DLG4_HUMAN (1002-1238): 1.07e-27: 123: 17.51
+	Mm
		1143412 SI1L1_MOUSE (3-1774): 0: 1206: 46.26		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51
+	Hs
		196436 SI1L1_HUMAN (3-1774): 0: 1211: 45.79		PTN13_HUMAN (978-1122): 1.17e-17: 92.2: 29.14
+	Hs
		1066194 RGPA2_HUMAN (361-868): 3.58e-125: 437: 17.93		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Dm
		114646 M9PD17_DROME (96-834): 4.01e-124: 434: 15.96		PATJ_DROME (969-1164): 1.83e-29: 129: 28.08
+	Hs
		1102434 RGPA2_HUMAN (361-868): 3.58e-125: 437: 17.93		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Hs
		835084 TSC2_HUMAN (227-876): 3.86e-138: 474: 15.77		INADL_HUMAN (1003-1089): 2.08e-11: 71.8: 25.81
+	Hs
		1151770 RGPA1_HUMAN (327-850): 4.76e-106: 379: 18.68		DLG3_HUMAN (1009-1467): 4.67e-23: 109: 13.25
+	Ce
		105545 H2L055_CAEEL (491-887): 2.84e-120: 401: 35.26		DLG1_CAEEL (1010-1092): 1.62e-13: 78.3: 27.06
+	Hs
		1056837 MDC1_HUMAN (1120-1713): 5.36e-10: 67: 13.41		KIF14_HUMAN (179-624): 8.03e-59: 227: 18.67
+	Ce
		103468 TTN1_CAEEL (985-1749): 6.14e-28: 126: 10.03		DLG1_CAEEL (1010-1092): 1.62e-13: 78.3: 27.06
+	Mm
		1143433 SYNJ1_MOUSE (1350-1764): 1.35e-09: 65.5: 12.33		DLG4_MOUSE (1002-1238): 8.46e-28: 123: 17.51