HitPredict

Interactor 1: PCDGC (O60330)
Protocadherin gamma-A12 (PCDH-gamma-A12) (Cadherin-21) (Fibroblast cadherin-3)
Gene: PCDHGA12

Interactor 2: PCDG4 (Q9Y5G9)
Protocadherin gamma-A4 (PCDH-gamma-A4)
Gene: PCDHGA4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Cadherin~Cadherin, Cadherin~Cadherin_2
Common GO terms	GO:0005509 - calcium ion binding GO:0005886 - plasma membrane GO:0007155 - cell adhesion GO:0007156 - homophilic cell adhesion via plasma membrane adhesion molecules GO:0007399 - nervous system development
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 932 Hs			1 962
+	Hs
		1378024 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDG4_HUMAN (1-947): 0: 1103: 100.00
+	Hs
		1378040 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDG4_HUMAN (1-947): 0: 1103: 100.00
+	Hs
		1377979 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDB3_HUMAN (59-804): 0: 613: 47.07
+	Hs
		1377963 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDB7_HUMAN (43-804): 0: 589: 45.48
+	Hs
		1378023 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDG5_HUMAN (1-586): 4.52e-118: 385: 22.99
+	Hs
		1378028 PCDG8_HUMAN (1-917): 0: 1116: 73.94		PCDG5_HUMAN (1-586): 4.52e-118: 385: 22.99
+	Hs
		1357414 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDA4_HUMAN (1-624): 2.16e-116: 381: 22.21
+	Hs
		1378046 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDAB_HUMAN (1-622): 3.34e-116: 380: 22.55
+	Hs
		1357424 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDAC_HUMAN (1-624): 6.57e-112: 369: 21.95
+	Hs
		1378026 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDA9_HUMAN (1-624): 3.8e-111: 367: 23.59
+	Hs
		1378044 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDA9_HUMAN (1-624): 3.8e-111: 367: 23.59
+	Hs
		1378018 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDGD_HUMAN (1-585): 4.66e-107: 355: 23.29
+	Hs
		1378013 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDGE_HUMAN (1-585): 8.16e-106: 352: 23.17
+	Hs
		1378016 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDGE_HUMAN (1-585): 8.16e-106: 352: 23.17
+	Hs
		231360 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDGC_HUMAN (3-392): 2.03e-65: 239: 20.20
+	Hs
		1378033 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDG7_HUMAN (10-378): 7.02e-65: 238: 21.03
+	Hs
		1378022 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDG8_HUMAN (3-402): 1.76e-64: 236: 20.84
+	Hs
		1378045 PCDGA_HUMAN (1-917): 0: 1118: 76.76		PCDA8_HUMAN (2-403): 3.2e-64: 236: 20.99
+	Hs
		1378025 PCDG9_HUMAN (1-917): 0: 1119: 73.17		PCDG3_HUMAN (2-156): 3.64e-09: 63: 15.57