Protein: RAP1A
Ras-related protein Rap-1A (EC 3.6.5.2) (C21KG) (G-22K) (GTP-binding protein smg p21A) (Ras-related protein Krev-1)

Gene: RAP1A
Organism: Homo sapiens
Interactions: 140
UniProt ID: P62834

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

400610

RAF1
RAF proto-oncogene serine/threonine-protein kinase

6

20

Small-scale

0.940

High

911822

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

4

10

Small-scale

0.902

High

982070

GNDS
Ral guanine nucleotide dissociation stimulator

4

20

Small-scale

0.879

High

578442

BRAF
Serine/threonine-protein kinase B-raf

3

20

Small-scale

0.834

High

982144

RPGF2
Rap guanine nucleotide exchange factor 2

2

20

Small-scale

0.799

High

982109

RASF5
Ras association domain-containing protein 5

2

10

Small-scale

0.786

High

982077

RPGF1
Rap guanine nucleotide exchange factor 1

2

20

Small-scale

0.778

High

982111

RPGF5
Rap guanine nucleotide exchange factor 5

2

20

Small-scale

0.778

High

908194

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

20

Small-scale

0.747

High

936289

AFAD
Afadin

1

20

Small-scale

0.740

High

890806

TSC2
Tuberin

2

14

Small-scale

0.737

High

298343

DNJC8
DnaJ homolog subfamily C member 8

1

4

High-throughput

0.691

High

862789

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

20

High-throughput

0.691

High

866374

MSS4
Guanine nucleotide exchange factor MSS4

1

4

High-throughput

0.691

High

982100

RYBP
RING1 and YY1-binding protein

1

5

High-throughput

0.691

High

982138

RGL1
Ral guanine nucleotide dissociation stimulator-like 1

1

20

High-throughput

0.691

High

220443

RGS14
Regulator of G-protein signaling 14

1

12

Small-scale

0.647

High

335728

RPGF3
Rap guanine nucleotide exchange factor 3

1

20

Small-scale

0.647

High

866519

RPGP1
Rap1 GTPase-activating protein 1

1

14

Small-scale

0.647

High

982099

RGDSR
Ral-GDS-related protein

1

20

Small-scale

0.647

High

982107

RPGF6
Rap guanine nucleotide exchange factor 6

1

20

Small-scale

0.647

High

982110

RPGF4
Rap guanine nucleotide exchange factor 4

1

20

Small-scale

0.647

High

982116

ARHG1
Rho guanine nucleotide exchange factor 1

1

20

Small-scale

0.647

High

231387

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

3

3

Small-scale

0.645

High

982105

EXOC6
Exocyst complex component 6

2

3

High-throughput

0.628

High

982115

KIFA3
Kinesin-associated protein 3

2

15

High-throughput

0.628

High

139126

KRIT1
Krev interaction trapped protein 1

1

20

Small-scale

0.621

High

297084

DGKI
Diacylglycerol kinase iota

1

12

Small-scale

0.618

High

375366

RASK
GTPase KRas

1

19

High-throughput

0.618

High

411703

NTRK1
High affinity nerve growth factor receptor

1

20

Small-scale

0.618

High

463440

LYN
Tyrosine-protein kinase Lyn

1

20

High-throughput

0.618

High

541424

FGFR1
Fibroblast growth factor receptor 1

1

20

Small-scale

0.618

High

822584

VHL
von Hippel-Lindau disease tumor suppressor

1

3

High-throughput

0.618

High

839230

MTOR
Serine/threonine-protein kinase mTOR

1

15

Small-scale

0.618

High

959315

RAP1B
Ras-related protein Rap-1b

1

19

High-throughput

0.618

High

977912

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

982085

RAB35
Ras-related protein Rab-35

1

18

High-throughput

0.618

High

982086

RHEB
GTP-binding protein Rheb

1

19

Small-scale

0.618

High

982094

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.618

High

982139

PLCE1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

1

19

Small-scale

0.618

High

982134

DUS22
Dual specificity protein phosphatase 22

2

10

High-throughput

0.611

High

982093

CPLX2
Complexin-2

2

0

High-throughput

0.602

High

869719

MTR1A
Melatonin receptor type 1A

2

6

Small-scale

0.601

High

982090

RUN3A
RUN domain-containing protein 3A

1

7

Small-scale

0.579

High

395843

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

905736

CAV2
Caveolin-2

2

9

High-throughput

0.571

High

138470

BIN1
Myc box-dependent-interacting protein 1

1

13

Small-scale

0.561

High

164913

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

7

Small-scale

0.561

High

674988

TNR6
Tumor necrosis factor receptor superfamily member 6

1

8

Small-scale

0.561

High

903120

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

Small-scale

0.561

High

982073

FADD
FAS-associated death domain protein

1

5

Small-scale

0.561

High

982074

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.561

High

982142

FAF1
FAS-associated factor 1

1

11

Small-scale

0.561

High

982122

RADIL
Ras-associating and dilute domain-containing protein

1

20

Small-scale

0.553

High

361206

SODC
Superoxide dismutase [Cu-Zn]

1

3

High-throughput

0.536

High

611825

RL35A
Large ribosomal subunit protein eL33

1

2

High-throughput

0.536

High

622042

CD53
Leukocyte surface antigen CD53

1

2

High-throughput

0.536

High

711547

NK3R
Neuromedin-K receptor

1

5

High-throughput

0.536

High

717762

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

8

Small-scale

0.536

High

787967

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

6

High-throughput

0.536

High

982097

CACL1
CDK2-associated and cullin domain-containing protein 1

1

9

High-throughput

0.536

High

982104

O2T10
Olfactory receptor 2T10

1

1

High-throughput

0.536

High

982135

CENPM
Centromere protein M

1

2

High-throughput

0.536

High

982141

LIMA1
LIM domain and actin-binding protein 1

1

20

High-throughput

0.536

High

982146

PCDA8
Protocadherin alpha-8

1

2

High-throughput

0.536

High

982082

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.518

High

172060

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

7

High-throughput

0.515

High

982078

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

7

High-throughput

0.515

High

982129

IFT22
Intraflagellar transport protein 22 homolog

1

18

High-throughput

0.515

High

906256

GPC3
Glypican-3

1

0

High-throughput

0.513

High

982088

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

982132

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

982137

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

0

High-throughput

0.513

High

982079

ELOA1
Elongin-A

1

9

Small-scale

0.512

High

761626

HSP74
Heat shock 70 kDa protein 4

1

8

Small-scale

0.501

High

952075

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

6

Small-scale

0.501

High

982068

1433Z
14-3-3 protein zeta/delta

1

13

Small-scale

0.501

High

166894

MGST3
Glutathione S-transferase 3, mitochondrial

1

1

High-throughput

0.489

High

230698

NKG2F
NKG2-F type II integral membrane protein

1

1

High-throughput

0.489

High

848234

MAGA3
Melanoma-associated antigen 3

1

2

High-throughput

0.489

High

982098

AGRF3
Adhesion G-protein coupled receptor F3

1

8

High-throughput

0.489

High

982106

PIGO
GPI ethanolamine phosphate transferase 3, catalytic subunit

1

1

High-throughput

0.489

High

982117

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.489

High

982120

SAAL1
Protein SAAL1

1

2

High-throughput

0.489

High

125391

LEG9
Galectin-9

1

8

High-throughput

0.479

High

189498

STX7
Syntaxin-7

1

20

High-throughput

0.479

High

241321

PRKN
E3 ubiquitin-protein ligase parkin

1

14

High-throughput

0.479

High

293517

CD123
Translation initiation factor eIF2 assembly protein

1

7

High-throughput

0.479

High

519918

ANDR
Androgen receptor

1

17

High-throughput

0.479

High

534897

BIP
Endoplasmic reticulum chaperone BiP

1

11

High-throughput

0.479

High

558018

XRCC6
X-ray repair cross-complementing protein 6

1

3

High-throughput

0.479

High

561983

LAMP2
Lysosome-associated membrane glycoprotein 2

1

12

High-throughput

0.479

High

606574

CEBPB
CCAAT/enhancer-binding protein beta

1

6

High-throughput

0.479

High

715524

MARCS
Myristoylated alanine-rich C-kinase substrate

1

13

High-throughput

0.479

High

774270

BASI
Basigin

1

18

High-throughput

0.479

High

883208

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

6

High-throughput

0.479

High

970261

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

982067

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

4

Small-scale

0.479

High

982071

LCP2
Lymphocyte cytosolic protein 2

1

9

Small-scale

0.479

High

982072

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

High-throughput

0.479

High

982075

CUL4A
Cullin-4A

1

8

High-throughput

0.479

High

982076

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

5

High-throughput

0.479

High

982080

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

6

High-throughput

0.479

High

982084

KIF14
Kinesin-like protein KIF14

1

12

High-throughput

0.479

High

982092

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

982096

TAXB1
Tax1-binding protein 1

1

20

High-throughput

0.479

High

982101

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

982103

RN149
E3 ubiquitin-protein ligase RNF149

1

14

High-throughput

0.479

High

982108

DUS19
Dual specificity protein phosphatase 19

1

9

High-throughput

0.479

High

982112

AKAP1
A-kinase anchor protein 1, mitochondrial

1

3

High-throughput

0.479

High

982114

REQU
Zinc finger protein ubi-d4

1

3

High-throughput

0.479

High

982118

CHM4C
Charged multivesicular body protein 4c

1

8

High-throughput

0.479

High

982123

CI072
Guanine nucleotide exchange factor C9orf72

1

4

High-throughput

0.479

High

982126

DUS9
Dual specificity protein phosphatase 9

1

9

High-throughput

0.479

High

982140

TRM7
tRNA

1

4

High-throughput

0.479

High

982145

TRAF6
TNF receptor-associated factor 6

1

18

High-throughput

0.479

High

982119

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.458

High

529545

TAU
Microtubule-associated protein tau

1

17

High-throughput

0.445

High

834950

S19A1
Reduced folate transporter

1

3

High-throughput

0.445

High

870221

S6A12
Sodium- and chloride-dependent betaine transporter

1

16

High-throughput

0.445

High

982069

VMAT2
Synaptic vesicular amine transporter

1

1

High-throughput

0.445

High

982089

S35G1
Solute carrier family 35 member G1

1

3

High-throughput

0.445

High

982102

CD177
CD177 antigen

1

5

Small-scale

0.445

High

982131

SO1B3
Solute carrier organic anion transporter family member 1B3

1

7

High-throughput

0.445

High

982081

RBM39
RNA-binding protein 39

1

12

High-throughput

0.437

High

982095

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

19

High-throughput

0.437

High

982113

ESR2
Estrogen receptor beta

1

17

High-throughput

0.437

High

982125

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

982128

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

2

High-throughput

0.437

High

982136

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

3

High-throughput

0.437

High

982130

ANKH
Mineralization regulator ANKH

1

0

High-throughput

0.426

High

982083

MFS10
Major facilitator superfamily domain-containing protein 10

1

6

High-throughput

0.407

High

982127

RM34
Large ribosomal subunit protein bL34m

2

0

High-throughput

0.328

High

280911

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

982091

TMM31
Transmembrane protein 31

1

0

High-throughput

0.279

Low

982121

BORC8
BLOC-1-related complex subunit 8

1

0

High-throughput

0.279

Low

982124

CC85A
Coiled-coil domain-containing protein 85A

1

0

High-throughput

0.279

Low

982133

DPOE3
DNA polymerase epsilon subunit 3

1

0

High-throughput

0.279

Low

982143

WASC3
WASH complex subunit 3

1

0

High-throughput

0.279

Low

982087

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025