HitPredict

Interactor 1: KDM1A (O60341)
Lysine-specific histone demethylase 1A (EC 1.14.99.66) (BRAF35-HDAC complex protein BHC110) (Flavin-containing amine oxidase domain-containing protein 2) ([histone H3]-dimethyl-L-lysine(4) FAD-dependent demethylase 1A)
Gene: KDM1A

Interactor 2: RCOR3 (Q9P2K3)
REST corepressor 3
Gene: RCOR3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.92	1.00	0.962

Property	Details
Experiments	32296183, 24981860, 34079125, 34709266, 21258344, 23455924, unassigned1304
Identification Methods	two hybrid, affinity chromatography technology, proximity labelling technology, two hybrid prey pooling approach, two hybrid array, validated two hybrid, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	Amino_oxidase~Myb_DNA-binding
Common GO terms	GO:0005654 - nucleoplasm GO:0005667 - transcription regulator complex GO:0006357 - regulation of transcription by RNA polymerase II GO:0045892 - negative regulation of DNA-templated transcription
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 852 Hs			1 495
+	Hs
		232578 KDM1A_HUMAN (1-852): 0: 936: 100.00		RCOR1_HUMAN (1-384): 4.93e-99: 308: 62.69
+	Hs
		231926 KDM1A_HUMAN (1-852): 0: 936: 100.00		MTA2_HUMAN (1-478): 7.19e-92: 295: 15.71
+	Mm
		1169746 KDM1A_MOUSE (1-852): 0: 922: 97.30		RCOR1_MOUSE (1-385): 5.12e-99: 308: 63.57
+	Hs
		232311 KDM1A_HUMAN (1-852): 0: 936: 100.00		RCOR2_HUMAN (1-494): 4.22e-92: 291: 55.44
+	Hs
		232471 KDM1A_HUMAN (1-852): 0: 936: 100.00		MTA3_HUMAN (1-418): 1.98e-89: 287: 15.86
+	Mm
		1169742 KDM1A_MOUSE (1-852): 0: 922: 97.30		RCOR2_MOUSE (1-494): 1.38e-93: 295: 55.44
+	Hs
		232141 KDM1A_HUMAN (1-852): 0: 936: 100.00		MTA1_HUMAN (1-433): 2.17e-85: 279: 15.62
+	Mm
		1169771 KDM1A_MOUSE (1-852): 0: 922: 97.30		MTA3_MOUSE (1-418): 5.87e-84: 272: 15.45
+	Hs
		231911 KDM1A_HUMAN (1-852): 0: 936: 100.00		NCOR1_HUMAN (35-484): 1.63e-51: 191: 17.04
+	Mm
		1169714 KDM1A_MOUSE (1-852): 0: 922: 97.30		RERE_MOUSE (1-495): 3.41e-51: 189: 17.00
+	Mm
		1169803 KDM1A_MOUSE (1-852): 0: 922: 97.30		NCOR2_MOUSE (35-478): 3.75e-48: 181: 18.47
+	Mm
		1169736 KDM1A_MOUSE (1-852): 0: 922: 97.30		TREF1_MOUSE (1-314): 3.19e-42: 163: 20.48
+	Mm
		1161359 KDM1A_MOUSE (1-852): 0: 922: 97.30		RCOR3_MOUSE (329-495): 1.09e-17: 87.5: 69.46
+	Dm
		1123846 LSDA_DROME (35-844): 0: 747: 50.41		RCOR_DROME (1-484): 4.5e-49: 179: 27.16
+	Ce
		1090390 KDM1A_CAEEL (182-831): 1.14e-174: 525: 27.60		RCORB_CAEEL (1-346): 1.53e-63: 217: 17.69
+	Ce
		1280107 KDM1A_CAEEL (182-831): 1.14e-174: 525: 27.60		RCORA_CAEEL (1-147): 1.83e-44: 166: 24.49
+	Hs
		1251644 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		RCOR1_HUMAN (1-384): 4.93e-99: 308: 62.69
+	Hs
		1223937 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		RCOR2_HUMAN (1-494): 4.22e-92: 291: 55.44
+	Hs
		261552 SMRC2_HUMAN (5-300): 1.17e-57: 216: 15.14		NCOR1_HUMAN (35-484): 1.63e-51: 191: 17.04
+	Hs
		261560 SMRC1_HUMAN (34-300): 1.41e-57: 216: 16.96		NCOR1_HUMAN (35-484): 1.63e-51: 191: 17.04