Protein: CBR1
Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)

Gene: CBR1
Organism: Homo sapiens
Interactions: 171
UniProt ID: P16152

Gene Ontology (top 5):
GO:0004090 - carbonyl reductase (NADPH) activity
GO:0005829 - cytosol
GO:0006805 - xenobiotic metabolic process
GO:0008211 - glucocorticoid metabolic process
GO:0016616 - oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

295384

CBR3
Carbonyl reductase [NADPH] 3

3

13

High-throughput

0.871

High

240667

PRKN
E3 ubiquitin-protein ligase parkin

3

5

High-throughput

0.640

High

395435

ESR1
Estrogen receptor

2

5

Small-scale

0.611

High

362710

EGFR
Epidermal growth factor receptor

2

5

Small-scale

0.608

High

563134

CFTR
Cystic fibrosis transmembrane conductance regulator

2

6

High-throughput

0.601

High

592920

AAKB1
5'-AMP-activated protein kinase subunit beta-1

2

0

High-throughput

0.585

High

410588

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

4

High-throughput

0.576

High

592797

CBR1
Carbonyl reductase [NADPH] 1

1

11

Small-scale

0.575

High

592877

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

592804

PAX6
Paired box protein Pax-6

1

1

High-throughput

0.541

High

592807

AGTR1
Type-1 angiotensin II receptor

1

3

High-throughput

0.541

High

592881

RANB9
Ran-binding protein 9

1

5

High-throughput

0.541

High

132562

UPK1A
Uroplakin-1a

1

7

High-throughput

0.536

High

213797

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

High-throughput

0.536

High

529009

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

592810

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

592818

NCBP2
Nuclear cap-binding protein subunit 2

1

4

High-throughput

0.536

High

592822

SC61B
Protein transport protein Sec61 subunit beta

1

2

High-throughput

0.536

High

592838

CUL1
Cullin-1

1

1

High-throughput

0.536

High

592845

MYLK
Myosin light chain kinase, smooth muscle

1

1

High-throughput

0.536

High

592872

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.536

High

592895

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.536

High

592897

KPCD2
Serine/threonine-protein kinase D2

1

4

High-throughput

0.536

High

592898

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

592904

MBNL1
Muscleblind-like protein 1

1

2

High-throughput

0.536

High

592885

ZBT18
Zinc finger and BTB domain-containing protein 18

2

2

Small-scale

0.521

High

592817

STA5B
Signal transducer and activator of transcription 5B

1

0

High-throughput

0.518

High

592827

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.518

High

592802

CRCM
Colorectal mutant cancer protein

1

4

High-throughput

0.515

High

60858

DEND3
DENN domain-containing protein 3

1

0

High-throughput

0.513

High

572771

NCF1
Neutrophil cytosol factor 1

1

0

High-throughput

0.513

High

592828

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

592833

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.513

High

592866

PPHLN
Periphilin-1

1

0

High-throughput

0.513

High

592889

ATGA1
Autophagy-related protein 101

1

0

High-throughput

0.513

High

185410

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

507500

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

592873

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

3

High-throughput

0.501

High

592813

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.494

High

156237

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.493

High

229209

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

1

High-throughput

0.489

High

355062

APBA3
Amyloid-beta A4 precursor protein-binding family A member 3

1

4

High-throughput

0.489

High

556838

MYH1
Myosin-1

1

3

High-throughput

0.489

High

592808

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

592831

SSBP2
Single-stranded DNA-binding protein 2

1

1

High-throughput

0.489

High

592846

CR021
UPF0711 protein C18orf21

1

1

High-throughput

0.489

High

592850

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

2

High-throughput

0.489

High

592851

Z518A
Zinc finger protein 518A

1

2

High-throughput

0.489

High

592857

ZC3C1
Zinc finger C3HC-type protein 1

1

1

High-throughput

0.489

High

592860

CDKL3
Cyclin-dependent kinase-like 3

1

5

High-throughput

0.489

High

592864

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.489

High

592867

RHBL4
Rhomboid-related protein 4

1

4

High-throughput

0.489

High

592874

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

592875

FAF2
FAS-associated factor 2

1

1

High-throughput

0.489

High

592887

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

4

High-throughput

0.489

High

592890

WAC
WW domain-containing adapter protein with coiled-coil

1

1

High-throughput

0.489

High

592899

S2532
Solute carrier family 25 member 32

1

3

High-throughput

0.489

High

592916

ICAM5
Intercellular adhesion molecule 5

1

2

High-throughput

0.489

High

592918

SSUH2
Protein SSUH2 homolog

1

2

High-throughput

0.489

High

592812

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.480

High

592891

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.479

High

131714

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

2

High-throughput

0.479

High

379860

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

2

High-throughput

0.479

High

520737

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

536437

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

592798

VDAC1
Non-selective voltage-gated ion channel VDAC1

1

5

High-throughput

0.479

High

592799

NDKB
Nucleoside diphosphate kinase B

1

3

High-throughput

0.479

High

592803

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

592806

PML
Protein PML

1

3

High-throughput

0.479

High

592815

CDK7
Cyclin-dependent kinase 7

1

3

High-throughput

0.479

High

592819

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

592823

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

4

High-throughput

0.479

High

592824

UBC12
NEDD8-conjugating enzyme Ubc12

1

3

High-throughput

0.479

High

592826

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

592829

1433Z
14-3-3 protein zeta/delta

1

4

Small-scale

0.479

High

592834

DHX9
ATP-dependent RNA helicase A

1

4

Small-scale

0.479

High

592837

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

592839

CUL3
Cullin-3

1

1

High-throughput

0.479

High

592840

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

592843

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

592865

SERB1
SERPINE1 mRNA-binding protein 1

1

3

High-throughput

0.479

High

592888

RIOK1
Serine/threonine-protein kinase RIO1

1

2

High-throughput

0.479

High

592909

MARH2
E3 ubiquitin-protein ligase MARCHF2

1

3

High-throughput

0.479

High

592912

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

592914

TNIK
TRAF2 and NCK-interacting protein kinase

1

1

High-throughput

0.479

High

592921

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.479

High

522586

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.460

High

225927

STX6
Syntaxin-6

1

0

High-throughput

0.458

High

238375

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

319367

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

345329

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

538867

EPB41
Protein 4.1

1

0

High-throughput

0.458

High

592800

CBL
E3 ubiquitin-protein ligase CBL

1

0

High-throughput

0.458

High

592814

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

592820

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

592832

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

592841

CUL7
Cullin-7

1

0

High-throughput

0.458

High

592871

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

592906

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

592911

TRM7
tRNA

1

0

High-throughput

0.458

High

592896

RNF26
E3 ubiquitin-protein ligase RNF26

1

3

Small-scale

0.457

High

184574

MK13
Mitogen-activated protein kinase 13

1

4

Small-scale

0.445

High

592821

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

592844

T22D1
TSC22 domain family protein 1

1

2

Small-scale

0.445

High

592847

KLH22
Kelch-like protein 22

1

1

High-throughput

0.445

High

592849

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

592852

OLFM4
Olfactomedin-4

1

1

High-throughput

0.445

High

592868

G6PT3
Glucose-6-phosphate exchanger SLC37A2

1

1

High-throughput

0.445

High

592903

ITM2C
Integral membrane protein 2C

1

3

High-throughput

0.445

High

592905

DDX28
Probable ATP-dependent RNA helicase DDX28

1

2

High-throughput

0.445

High

592917

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

128498

RN103
E3 ubiquitin-protein ligase RNF103

1

4

High-throughput

0.437

High

227356

SPOP
Speckle-type POZ protein

1

3

High-throughput

0.437

High

371084

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

411301

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

587855

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

592805

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

592809

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

592811

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.437

High

592848

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

5

High-throughput

0.437

High

592853

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

592855

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.437

High

592856

MARH3
E3 ubiquitin-protein ligase MARCHF3

1

3

High-throughput

0.437

High

592870

CLC4D
C-type lectin domain family 4 member D

1

2

High-throughput

0.437

High

592878

RN185
E3 ubiquitin-protein ligase RNF185

1

3

High-throughput

0.437

High

592880

IMP1L
Mitochondrial inner membrane protease subunit 1

1

3

High-throughput

0.437

High

592882

IMP2L
Mitochondrial inner membrane protease subunit 2

1

3

High-throughput

0.437

High

592883

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.437

High

592892

TM208
Transmembrane protein 208

1

2

High-throughput

0.437

High

592900

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

3

High-throughput

0.437

High

592901

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

592902

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

592910

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

3

High-throughput

0.437

High

592915

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

592835

ERCC8
DNA excision repair protein ERCC-8

1

2

High-throughput

0.417

High

116276

H3BMW4
Transmembrane protein 208

1

2

High-throughput

0.407

High

261076

NSMA
Sphingomyelin phosphodiesterase 2

1

2

High-throughput

0.407

High

330035

VENTX
Homeobox protein VENTX

1

2

High-throughput

0.407

High

429250

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

592836

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.407

High

592854

NEK10
Serine/threonine-protein kinase Nek10

1

2

High-throughput

0.407

High

194456

P2RX6
P2X purinoceptor 6

1

0

High-throughput

0.279

Low

592858

CERS3
Ceramide synthase 3

1

0

High-throughput

0.279

Low

592861

PKHM2
Pleckstrin homology domain-containing family M member 2

1

0

High-throughput

0.279

Low

592862

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

592869

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

592893

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

592894

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

592908

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.279

Low

592913

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

105266

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

254517

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.249

Low

259388

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

352317

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

560299

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.249

Low

592825

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

592830

TYB10
Thymosin beta-10

1

0

High-throughput

0.249

Low

592842

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

Small-scale

0.249

Low

592863

AGRG4
Adhesion G-protein coupled receptor G4

1

0

High-throughput

0.249

Low

592876

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.249

Low

592879

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

592886

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.249

Low

592919

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

915

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

554146

BMP4
Bone morphogenetic protein 4

1

0

High-throughput

0.232

Low

592801

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

592816

GPC3
Glypican-3

1

0

High-throughput

0.232

Low

592859

LACC1
Purine nucleoside phosphorylase LACC1

1

0

Small-scale

0.232

Low

592884

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

592907

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025