Protein: K2C5
Keratin, type II cytoskeletal 5 (58 kDa cytokeratin) (Cytokeratin-5) (CK-5) (Keratin-5) (K5) (Type-II keratin Kb5)

Gene: K2C5, KRT5
Organism: Homo sapiens
Interactions: 162
UniProt ID: P13647

Gene Ontology (top 5):
GO:0005200 - structural constituent of cytoskeleton
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

280947

KRT38
Keratin, type I cuticular Ha8

3

20

High-throughput

0.871

High

531531

K1C15
Keratin, type I cytoskeletal 15

3

20

High-throughput

0.871

High

531577

K1H1
Keratin, type I cuticular Ha1

3

20

High-throughput

0.871

High

531587

K1C40
Keratin, type I cytoskeletal 40

3

20

High-throughput

0.871

High

359299

K1C14
Keratin, type I cytoskeletal 14

1

20

Small-scale

0.809

High

444305

K1C19
Keratin, type I cytoskeletal 19

2

20

High-throughput

0.783

High

445000

K1C16
Keratin, type I cytoskeletal 16

2

20

High-throughput

0.783

High

531580

K1C24
Keratin, type I cytoskeletal 24

2

20

High-throughput

0.783

High

531596

K1C28
Keratin, type I cytoskeletal 28

2

20

High-throughput

0.783

High

531597

K1C27
Keratin, type I cytoskeletal 27

2

20

High-throughput

0.783

High

531598

K1C25
Keratin, type I cytoskeletal 25

2

20

High-throughput

0.783

High

531611

KRT35
Keratin, type I cuticular Ha5

2

20

High-throughput

0.783

High

408722

K1C18
Keratin, type I cytoskeletal 18

2

20

Small-scale

0.744

High

531623

KIFC3
Kinesin-like protein KIFC3

3

9

High-throughput

0.675

High

280519

KRT34
Keratin, type I cuticular Ha4

1

20

High-throughput

0.621

High

280773

KRT36
Keratin, type I cuticular Ha6

1

20

High-throughput

0.621

High

280849

KRT37
Keratin, type I cuticular Ha7

1

20

High-throughput

0.621

High

531441

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.621

High

531569

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.621

High

531570

K1H2
Keratin, type I cuticular Ha2

1

20

High-throughput

0.621

High

531555

K1C17
Keratin, type I cytoskeletal 17

1

20

High-throughput

0.618

High

531560

MTM1
Myotubularin

2

1

High-throughput

0.611

High

531558

INCA1
Protein INCA1

2

1

High-throughput

0.606

High

255473

OBSL1
Obscurin-like protein 1

2

7

High-throughput

0.584

High

386010

P53
Cellular tumor antigen p53

2

7

Small-scale

0.584

High

531581

LARP7
La-related protein 7

2

10

High-throughput

0.584

High

337855

EGFR
Epidermal growth factor receptor

2

6

Small-scale

0.571

High

531621

PKP2
Plakophilin-2

1

6

Small-scale

0.561

High

531530

LOX12
Polyunsaturated fatty acid lipoxygenase ALOX12

1

0

Small-scale

0.549

High

531535

APC
Adenomatous polyposis coli protein

1

3

High-throughput

0.541

High

317401

YETS4
YEATS domain-containing protein 4

1

1

High-throughput

0.536

High

362766

FINC
Fibronectin

1

5

High-throughput

0.536

High

363709

ALBU
Albumin

1

2

High-throughput

0.536

High

531557

BTK
Tyrosine-protein kinase BTK

1

2

Small-scale

0.536

High

531561

CUL1
Cullin-1

1

20

High-throughput

0.536

High

531562

CUL2
Cullin-2

1

20

High-throughput

0.536

High

531563

CUL3
Cullin-3

1

20

High-throughput

0.536

High

531564

CUL4B
Cullin-4B

1

20

High-throughput

0.536

High

531574

FL2D
Pre-mRNA-splicing regulator WTAP

1

5

High-throughput

0.536

High

531578

NEDD8
NEDD8

1

3

High-throughput

0.536

High

531595

CSN6
COP9 signalosome complex subunit 6

1

9

High-throughput

0.536

High

531599

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

12

High-throughput

0.536

High

531601

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

5

High-throughput

0.536

High

531607

RIN3
Ras and Rab interactor 3

1

2

High-throughput

0.536

High

531613

CSN5
COP9 signalosome complex subunit 5

1

14

High-throughput

0.536

High

531614

CUL5
Cullin-5

1

20

High-throughput

0.536

High

531619

DCNL1
DCN1-like protein 1

1

3

High-throughput

0.536

High

531632

P63
Tumor protein 63

1

7

Small-scale

0.536

High

531635

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

12

High-throughput

0.536

High

531622

TCHP
Trichoplein keratin filament-binding protein

1

5

Small-scale

0.527

High

531556

UBE3A
Ubiquitin-protein ligase E3A

1

3

Small-scale

0.501

High

531553

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

5

High-throughput

0.484

High

129188

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

133866

DDX3X
ATP-dependent RNA helicase DDX3X

1

4

Small-scale

0.479

High

176371

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

7

High-throughput

0.479

High

197211

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

214064

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

226397

PRKN
E3 ubiquitin-protein ligase parkin

1

11

High-throughput

0.479

High

260468

PITX3
Pituitary homeobox 3

1

3

Small-scale

0.479

High

282510

RNF8
E3 ubiquitin-protein ligase RNF8

1

12

High-throughput

0.479

High

301586

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

302856

HEXI1
Protein HEXIM1

1

17

High-throughput

0.479

High

325613

LATS1
Serine/threonine-protein kinase LATS1

1

4

High-throughput

0.479

High

345816

MYC
Myc proto-oncogene protein

1

10

High-throughput

0.479

High

378970

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

414555

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

2

Small-scale

0.479

High

428902

ADRB2
Beta-2 adrenergic receptor

1

1

High-throughput

0.479

High

450698

F16P1
Fructose-1,6-bisphosphatase 1

1

3

High-throughput

0.479

High

453117

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

488553

ARAF
Serine/threonine-protein kinase A-Raf

1

5

High-throughput

0.479

High

528450

CFTR
Cystic fibrosis transmembrane conductance regulator

1

16

High-throughput

0.479

High

531529

DESP
Desmoplakin

1

18

Small-scale

0.479

High

531532

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

531534

CBL
E3 ubiquitin-protein ligase CBL

1

10

High-throughput

0.479

High

531536

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.479

High

531537

IF4A3
Eukaryotic initiation factor 4A-III

1

9

High-throughput

0.479

High

531538

EPS15
Epidermal growth factor receptor substrate 15

1

11

High-throughput

0.479

High

531539

CRK
Adapter molecule crk

1

20

High-throughput

0.479

High

531540

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

531541

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

1

High-throughput

0.479

High

531542

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.479

High

531545

TERA
Transitional endoplasmic reticulum ATPase

1

4

High-throughput

0.479

High

531547

MGN
Protein mago nashi homolog

1

2

High-throughput

0.479

High

531548

RND3
Rho-related GTP-binding protein RhoE

1

1

High-throughput

0.479

High

531549

SUMO2
Small ubiquitin-related modifier 2

1

3

Small-scale

0.479

High

531550

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.479

High

531551

GRB2
Growth factor receptor-bound protein 2

1

15

High-throughput

0.479

High

531552

ARF5
ADP-ribosylation factor 5

1

1

High-throughput

0.479

High

531559

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

18

High-throughput

0.479

High

531565

PKP1
Plakophilin-1

1

4

Small-scale

0.479

High

531566

DX39B
Spliceosome RNA helicase DDX39B

1

18

High-throughput

0.479

High

531571

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

18

High-throughput

0.479

High

531572

CUL7
Cullin-7

1

5

High-throughput

0.479

High

531575

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

531576

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

13

High-throughput

0.479

High

531579

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.479

High

531582

MIDN
Midnolin

1

1

High-throughput

0.479

High

531583

DCAF6
DDB1- and CUL4-associated factor 6

1

6

High-throughput

0.479

High

531586

VIR
Protein virilizer homolog

1

4

High-throughput

0.479

High

531588

PRP8
Pre-mRNA-processing-splicing factor 8

1

7

High-throughput

0.479

High

531590

RICTR
Rapamycin-insensitive companion of mTOR

1

4

High-throughput

0.479

High

531592

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

6

High-throughput

0.479

High

531593

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

531594

MEPCE
7SK snRNA methylphosphate capping enzyme

1

10

High-throughput

0.479

High

531602

RBM45
RNA-binding protein 45

1

1

High-throughput

0.479

High

531603

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.479

High

531605

TNIP2
TNFAIP3-interacting protein 2

1

3

High-throughput

0.479

High

531606

TRI58
E3 ubiquitin-protein ligase TRIM58

1

6

Small-scale

0.479

High

531608

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

20

High-throughput

0.479

High

531609

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

531610

RND1
Rho-related GTP-binding protein Rho6

1

1

High-throughput

0.479

High

531612

HDAC2
Histone deacetylase 2

1

10

High-throughput

0.479

High

531615

ZUP1
Zinc finger-containing ubiquitin peptidase 1

1

6

Small-scale

0.479

High

531616

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

531617

AP2M1
AP-2 complex subunit mu

1

7

High-throughput

0.479

High

531618

RNF31
E3 ubiquitin-protein ligase RNF31

1

13

High-throughput

0.479

High

531620

NECD
Necdin

1

3

High-throughput

0.479

High

531625

ACE2
Angiotensin-converting enzyme 2

1

5

High-throughput

0.479

High

531626

TRI31
E3 ubiquitin-protein ligase TRIM31

1

9

High-throughput

0.479

High

531628

DDX24
ATP-dependent RNA helicase DDX24

1

16

High-throughput

0.479

High

531630

CCDC8
Coiled-coil domain-containing protein 8

1

3

High-throughput

0.479

High

531631

RN208
RING finger protein 208

1

19

Small-scale

0.479

High

531634

NMRL1
NmrA-like family domain-containing protein 1

1

1

High-throughput

0.479

High

531636

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

9

High-throughput

0.479

High

531637

ANLN
Anillin

1

10

High-throughput

0.479

High

531638

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

531639

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

Small-scale

0.479

High

531642

HDAC6
Histone deacetylase 6

1

11

High-throughput

0.479

High

531643

KS6B2
Ribosomal protein S6 kinase beta-2

1

4

High-throughput

0.479

High

531644

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

531645

FZR1
Fizzy-related protein homolog

1

8

High-throughput

0.479

High

531646

FAF1
FAS-associated factor 1

1

3

High-throughput

0.479

High

531648

TRAF6
TNF receptor-associated factor 6

1

20

Small-scale

0.479

High

531554

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

531640

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

531641

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

0

High-throughput

0.458

High

305939

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

20

High-throughput

0.445

High

353629

IGHG1
Immunoglobulin heavy constant gamma 1

1

4

High-throughput

0.445

High

496199

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

531528

TCTP
Translationally-controlled tumor protein

1

2

Small-scale

0.445

High

531546

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

20

High-throughput

0.445

High

531567

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

4

High-throughput

0.445

High

531584

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

High-throughput

0.445

High

531600

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.445

High

531627

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

20

High-throughput

0.445

High

531629

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

20

High-throughput

0.445

High

531633

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

20

High-throughput

0.445

High

181050

INSI1
Insulin-induced gene 1 protein

1

6

High-throughput

0.437

High

352467

TNFA
Tumor necrosis factor

1

4

High-throughput

0.437

High

531533

EFNA1
Ephrin-A1

1

20

High-throughput

0.437

High

531543

EFNA3
Ephrin-A3

1

20

High-throughput

0.437

High

531544

EFNA4
Ephrin-A4

1

20

High-throughput

0.437

High

531568

TRI29
Tripartite motif-containing protein 29

1

10

Small-scale

0.437

High

531573

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.437

High

531585

RC3H1
Roquin-1

1

5

High-throughput

0.437

High

531591

LRC31
Leucine-rich repeat-containing protein 31

1

7

High-throughput

0.437

High

531604

NIN
Ninein

1

13

High-throughput

0.437

High

531624

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

5

High-throughput

0.437

High

531647

AAR2
Protein AAR2 homolog

1

5

High-throughput

0.437

High

531649

INSI2
Insulin-induced gene 2 protein

1

6

High-throughput

0.437

High

914

SIM26
Small integral membrane protein 26

1

5

High-throughput

0.407

High

531589

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024