HitPredict

Interactor 1: PHLP1 (O60346)
PH domain leucine-rich repeat-containing protein phosphatase 1 (EC 3.1.3.16) (Pleckstrin homology domain-containing family E member 1) (PH domain-containing family E member 1) (Suprachiasmatic nucleus circadian oscillatory protein) (hSCOP)
Gene: PHLPP1

Interactor 2: AKT2 (P31751)
RAC-beta serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-2) (Protein kinase B beta) (PKB beta) (RAC protein kinase beta) (RAC-PK-beta)
Gene: AKT2

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17386267
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	LRR_6~Pkinase, PH~PH, PH~Pkinase, PP2C~Pkinase
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0046872 - metal ion binding
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 1717 Hs			1 481
+	Hs
		232791 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		233019 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		AKT3_HUMAN (1-481): 0: 550: 76.61
+	Hs
		232762 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63
+	Hs
		232782 PHLP1_HUMAN (1-1717): 0: 1504: 100.00		KS6B1_HUMAN (134-478): 1.35e-146: 431: 44.13
+	Hs
		682190 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT2_HUMAN (1-481): 0: 589: 100.00
+	Hs
		681911 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Rn
		88885 D4A254_RAT (469-1717): 0: 869: 52.84		AKT1_RAT (1-478): 0: 566: 81.84
+	Hs
		1172970 PHLP2_HUMAN (469-1717): 0: 884: 53.15		AKT3_HUMAN (1-481): 0: 550: 76.61
+	Hs
		408635 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KPCB_HUMAN (72-478): 5.56e-147: 436: 40.63
+	Hs
		616717 PHLP2_HUMAN (469-1717): 0: 884: 53.15		KS6B1_HUMAN (134-478): 1.35e-146: 431: 44.13
+	Hs
		682184 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT2_HUMAN (1-481): 0: 589: 100.00
+	Hs
		681889 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		AKT1_HUMAN (1-478): 0: 564: 81.63
+	Hs
		1130690 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6B2_HUMAN (115-478): 1.21e-147: 432: 41.58
+	Hs
		568694 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KAPCA_HUMAN (141-447): 2.12e-144: 419: 41.69
+	Hs
		850667 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KS6A3_HUMAN (55-452): 8.73e-107: 335: 23.36
+	Hs
		784024 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96
+	Hs
		983856 LRRK2_HUMAN (716-1019): 5.96e-18: 93.2: 29.32		KPCZ_HUMAN (149-475): 9.44e-101: 315: 46.43
+	Hs
		1073471 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KS6A1_HUMAN (55-456): 2.33e-109: 342: 23.13
+	Hs
		784073 ERBIN_HUMAN (637-806): 2.73e-09: 64.3: 26.86		KPCI_HUMAN (142-475): 3.18e-106: 330: 46.96