HitPredict

Interactor 1: PEPL (O60437)
Periplakin (190 kDa paraneoplastic pemphigus antigen) (195 kDa cornified envelope precursor protein)
Gene: PPL

Interactor 2: ITPR3 (Q14573)
Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor)
Gene: ITPR3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 1756 Hs			1 2671
+	Hs
		724830 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		ITPR3_HUMAN (1-2671): 0: 4288: 100.00
+	Hs
		234216 PEPL_HUMAN (1-1756): 3.44e-127: 441: 100.00		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Hs
		1056289 PLEC_HUMAN (1-1360): 9.93e-42: 171: 10.15		ITPR1_HUMAN (2-2663): 0: 3900: 60.67
+	Hs
		724829 MYH9_HUMAN (772-1656): 1.06e-32: 141: 16.74		ITPR2_HUMAN (3-2663): 0: 3897: 64.52
+	Rn
		555252 SPTN1_RAT (4-1212): 4.9e-19: 96.8: 10.10		ITPR1_RAT (2-2663): 0: 3906: 60.98
+	Rn
		670513 Q6XD99_RAT (9-796): 3.2e-12: 74.5: 9.59		ITPR1_RAT (2-2663): 0: 3906: 60.98
+	Mm
		93490 PLEC_MOUSE (2-1071): 1.05e-33: 145: 10.58		RYR2_MOUSE (1712-2183): 2.44e-45: 184: 19.37
+	Mm
		93464 MYH1_MOUSE (1-850): 5.03e-29: 129: 8.28		RYR2_MOUSE (1712-2183): 2.44e-45: 184: 19.37
+	Hs
		551607 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		RYR1_HUMAN (1714-2183): 9.62e-50: 199: 19.89
+	Hs
		551717 DESP_HUMAN (1031-1718): 1.69e-13: 78.7: 12.03		RYR3_HUMAN (1710-1960): 2.85e-45: 184: 24.06